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IKK beta(Tyr199) Antibody, ALEXA FLUOR 488

IKK beta(Tyr199) Antibody, ALEXA FLUOR 488 size: 100ul 350

Supplier BIOSS PRIMARY CONJUGATED ANTIBODIES
Price 350
Size 100ul
Contact us Ask Component cell markers and DNA bp. markers are genetic markerser genes or DNA sequenceswith selection audit
Long name ALEXA FLUOR 488 Conjugated, IKK beta(Tyr199) Polyclonal Antibody
Also known asAnti-IKK beta Tyr199 PAb ALEXA FLUOR 488
CategoryConjugated Primary Antibodies
Conjugated with 488, ALEXA FLUOR®
Host OrganismRabbit (Oryctolagus cuniculus)
Target AntigenIKK beta Tyr199
SpecificityThis is a highly specific antibody against IKK beta Tyr199
ModificationPhosphorylation
Modification SiteTyr199
ClonalityPolyclonal
ClonePolyclonal antibody
Concentration1ug per 1ul
Immunogen range180-230/756
Subcellular location Nucleus, Cytoplasm
SourceKLH conjugated synthetic phosphopeptide derived from human IKK beta around the phosphorylation site of Tyr199
Gene ID Number3551
Swiss ProtO14920
Tested applicationsIF(IHC-P)
Recommended dilutionsIF(IHC-P)(1:50-200)
Crossreactivity Mouse, Rat, Human
Cross-reactive species details not every possible cross-reactivity is known, Due to limited amount of testing and knowledge
Background of the antigen Acts as part of the canonical IKK complex in the conventional pathway of NF-kappa-B activation and phosphorylates inhibitors of NF-kappa-B on 2 critical serine residues, Also phosphorylates other substrates including NCOA3, BCL10 and IRS1, DNA damages or other cellular stresses, IKK-related kinase phosphorylations may prevent the overproduction of inflammatory mediators since they exert a negative regulation on canonical IKKs, In addition to the NF-kappa-B inhibitors, In turn, NF-kappa-B subunits RELA and NFKB1, These modifications allow polyubiquitination of the inhibitors and subsequent degradation by the proteasome, Within the nucleus, acts as an adapter protein for NFKBIA degradation in UV-induced NF-kappa-B activation, as well as IKK-related kinases TBK1 and IKBKE, bacterial or viral products, free NF-kappa-B is translocated into the nucleus and activates the transcription of hundreds of genes involved in immune response, growth control, or protection against apoptosis, phosphorylates several other components of the signaling pathway including NEMO/IKBKG, Serine kinase that plays an essential role in the NF-kappa-B signaling pathway which is activated by multiple stimuli such as inflammatory cytokines
PurificationPurified by Protein A
Storage conditions 50% glycerol and 0, Keep refrigerated at 2 to 8 degrees Celcius for up to one year, 09% sodium azide, Store this antibody in aqueous buffered solution containing 1% BSA
Excitation emission499nm/519nm
Synonyms I-kappa-B kinase 2, I-kappa-B-kinase beta, IKK-B, IKK-beta, IKKB, IMD15, IkBKB, Inhibitor of nuclear factor kappa-B kinase subunit beta, NFKBIKB, Nuclear factor NF-kappa-B inhibitor kinase beta, IKK2
Properties ALEXA FLUOR they should be stored frozen at - 24°, Alexa Fluor 488 has the same range to that of fluorescein isothiocyanate (FITC), Also Alexa Fluor 488 is pH stable, As a result of this photo stability, If you buy Antibodies supplied by Bioss Primary Conjugated Antibodies, It is distinguished in the FL1 of a FACS-Calibur or FACScan, has a very high photo stability, it has turned into an antibody for fluorescent microscopy and FACS FLOW cytometry, yet the IKK beta(Tyr199) Antibody, C, C for long term storage and for short term at + 5°, For facs or microscopy Alexa 1 conjugate
ConjugationAlexa Fluor
Gene targetIKK beta(Tyr199)
Short nameIKK beta(Tyr199) Antibody
Technique antibodies against human proteins, antibodies for, Antibody
LabelALEXA FLUOR 488
Alternative name ALEXA FLUOR 488, IKK b(Tyr199) (Antibody to)
Alternative techniqueantibodies

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