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IKK beta(Tyr199) Antibody, Biotin Conjugated

IKK beta(Tyr199) Antibody, Biotin Conjugated size: 0.1ml 350

Supplier BIOSS PRIMARY CONJUGATED ANTIBODIES 1
Price 350
Size 0.1ml
Contact us Ask Component cell markers and DNA bp. markers are genetic markerser genes or DNA sequenceswith selection audit
Long name Biotin Conjugated, IKK beta(Tyr199) Polyclonal Antibody
CategoryConjugated Primary Antibodies
ConjugationBiotinylated
Host OrganismRabbit (Oryctolagus cuniculus)
Target AntigenIKK beta Tyr199
Specificity This phosphorylation site is homologous across the listed species, This is a highly specific antibody against IKK beta Tyr199
ModificationPhosphorylation
Modification siteTyr199
ClonalityPolyclonal
ClonePolyclonal antibody
Concentration1ug per 1ul
Immunogen_range180-230/756
Subcellular location Nucleus, Cytoplasm
SourceKLH conjugated synthetic phosphopeptide derived from human IKK beta around the phosphorylation site of Tyr199
Gene ID number3551
Swiss ProtO14920
Tested applications IHC-P, WB
Recommended dilutions IHC-P(1:100-500), WB(1:100-1000)
Crossreactivity Mouse, Rat, Human
Crossreactive species details not every possible cross-reactivity is known, Due to limited amount of testing and knowledge
Antigen background Acts as part of the canonical IKK complex in the conventional pathway of NF-kappa-B activation and phosphorylates inhibitors of NF-kappa-B on 2 critical serine residues, Also phosphorylates other substrates including NCOA3, BCL10 and IRS1, DNA damages or other cellular stresses, IKK-related kinase phosphorylations may prevent the overproduction of inflammatory mediators since they exert a negative regulation on canonical IKKs, In addition to the NF-kappa-B inhibitors, In turn, NF-kappa-B subunits RELA and NFKB1, These modifications allow polyubiquitination of the inhibitors and subsequent degradation by the proteasome, Within the nucleus, acts as an adapter protein for NFKBIA degradation in UV-induced NF-kappa-B activation, as well as IKK-related kinases TBK1 and IKBKE, bacterial or viral products, free NF-kappa-B is translocated into the nucleus and activates the transcription of hundreds of genes involved in immune response, growth control, or protection against apoptosis, phosphorylates several other components of the signaling pathway including NEMO/IKBKG, Serine kinase that plays an essential role in the NF-kappa-B signaling pathway which is activated by multiple stimuli such as inflammatory cytokines
Purification methodThis antibody was purified via Protein A
Storage conditions 50% glycerol and 0, Store refrigerated at 2 to 8 degrees Celcius for up to 1 year, 09% sodium azide, Keep the antibody in an aqueous buffered solution containing 1% BSA
Excitation EmissionN/A
Synonyms I-kappa-B kinase 2, I-kappa-B-kinase beta, IKK-B, IKK-beta, IKKB, IMD15, IkBKB, Inhibitor of nuclear factor kappa-B kinase subunit beta, NFKBIKB, Nuclear factor NF-kappa-B inhibitor kinase beta, IKK2
Properties Avidin and Streptavidin bind to the small biotin and are couple to HRP or AP for ELISA, Biotin conjugates can be detected by horseradish peroxidase, To break the streptavidin Biotin bond we suggest to use a 6 molar guanidine HCl solution with acidity of pH 1, alkaline phosphatase substrates or anti biotin conjugated antibodies, 6, C, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by Bioss Primary Conjugated Antibodies they should be stored frozen at - 24°
Gene targetIKK beta(Tyr199) Conjugated
Short name Conjugated, IKK beta(Tyr199) Antibody
Technique antibodies against human proteins, antibodies for, antibody Conjugates, Antibody
LabelBiotin
Alternative name biotinilated coupled, IKK b(Tyr199) (Antibody to)
Alternative techniqueantibodies

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