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IKKi(Ser172) Antibody

IKKi(Ser172) Antibody size: 0.1ml 281

Supplier BIOSS PRIMARY UNCONJUGATED ANTIBODIES
Price 281
Size 0.1ml
Contact us Ask Component cell markers and DNA bp. markers are genetic markerser genes or DNA sequenceswith selection audit
Long nameIKKi(Ser172) Primary Polyclonal Antibody
Also known asIKKi(Ser172) PAb
CategoryPrimary Antibodies
ConjugationUnconjugated
Target AntigenIKKi Ser172
SpecificityThis is a highly specific antibody against IKKi Ser172
Modification(s)Phosphorylation
Modification site(s)Ser172
ClonalityPolyclonal antibody
Clone numberPolyclonal antibody
Concentration1ug per 1ul
Immunogen range145-180/716
SourceKLH conjugated synstic phosphopeptide derived from human IKKi/IKKE around the phosphorylation site of Ser172 [FV(p-S)VY]
Gene ID number9641
Swiss ProtQ14164
Tested Applications IF(IHC-P), IHC-P, WB
Recommended dilutions IF(IHC-P)(1:50-200), IHC-P(1:100-500), WB(1:100-1000)
Cross reactivity Mouse, Rat, Human
Cross reactive species details not every possible cross-reactivity is known, Due to limited amount of testing and knowledge
Background of the target antigen AZI2/NAP1 or TBKBP1/SINTBAD can be recruited to the IKBKE-containing-complexes, Activated by polyubiquitination in response to TNFA and interleukin-1, Also involved in TNFA and inflammatory cytokines, Also plays an important role in energy balance regulation by sustaining a state of chronic, Following activation of viral RNA sensors, IKBKE forms several different complexes whose composition depends on the type of cell and cellular stimuli, IRF3 and IRF7, In addition, In order to establish such an antiviral state, NF-kappa-B and STAT signaling, Phosphorylates AKT1, Phosphorylates inhibitors of NF-kappa-B thus leading to the dissociation of the inhibitor/NF-kappa-B complex and ultimately the degradation of the inhibitor, Phosphorylation of STAT1 at 'Ser-708' seems also to promote the assembly and DNA binding of ISGF3 (STAT1:STAT2:IRF9) complexes compared to GAF (STAT1:STAT1) complexes, Protects cells against DNA damage-induced cell death, TANK, This activity allows subsequent homodimerization and nuclear translocation of the IRF3 leading to transcriptional activation of pro-inflammatory and antiviral genes including IFNB, Thus, as well as DDX3X, associates with DDX3X and phosphorylates interferon regulatory factors (IRFs), at least, in this way regulating the balance between type I and type II IFN responses, is also required for the induction of a subset of ISGs which displays antiviral activity, like Interleukin-1, low-grade inflammation in obesity, may be through the phosphorylation of STAT1 at 'Ser-708', regulates the NF-kappa-B signaling pathway through, several scaffolding molecules including IPS1/MAVS, signaling, such as RIG-I-like receptors, the phosphorylation of CYLD, through the activation of the type I IFN, wich leads to a negative impact on insulin sensitivity, Serine/threonine kinase that plays an essential role in regulating inflammatory responses to viral infection
Purification methodThis antibody was purified via Protein A
Storage conditions 50% glycerol and 0, Store at -20°, 09% sodium azide, C for up to 1 year, Keep the antibody in aqueous buffered solution containing 1% BSA
Synonym names I-kappa-B kinase epsilon, IKK-E, IKK-epsilon, IKK-i, IKKI, IkBKE, Inducible I kappa-B kinase, Inhibitor of nuclear factor kappa-B kinase subunit epsilon, KIAA0151, IKKE
PropertiesC, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by Bioss Primary Unconjugated Antibodies they should be stored frozen at - 24°
Gene targetIKKi(Ser172)
Short nameIKKi(Ser172) Antibody
Technique antibodies against human proteins, antibodies for, Antibody
Alternative nameIKKi(Ser172) (Antibody to)
Alternative techniqueantibodies

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