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IMP4/SPPL2B Antibody

IMP4/SPPL2B Antibody size: 0.1ml 263

Supplier BIOSS PRIMARY UNCONJUGATED ANTIBODIES
Price 263
Size 0.1ml
Contact us Ask Component cell markers and DNA bp. markers are genetic markerser genes or DNA sequenceswith selection audit
Long nameIMP4/SPPL2B Primary Polyclonal Antibody
Also known asIMP4/SPPL2B PAb
CategoryPrimary Antibodies
ConjugationUnconjugated
Target AntigenIMP4/SPPL2B
SpecificityThis is a highly specific antibody against IMP4/SPPL2B
Modification(s)None
Modification site(s)Unmodified antibody
ClonalityPolyclonal antibody
Clone numberPolyclonal antibody
Concentration1ug per 1ul
SourceThis antibody was obtained by immunization of the host with KLH conjugated synthetic peptide derived from human SPPL2B
Tested Applications IF(IHC-P), IHC-P, WB
Recommended dilutions IF(IHC-P)(1:50-200), IHC-P(1:100-500), WB(1:100-1000)
Cross reactivity Mouse, Rat, Human
Cross reactive species details not every possible cross-reactivity is known, Due to limited amount of testing and knowledge
Background of the target antigen Four isoforms of SPPL2b exist due to alternative splicing events, Localized to the membrane of the Golgi apparatus and to lysosomes, SPPL2b also interacts with and catalyzes the intramembrane proteolysis of ITM2B (integral membrane protein 2B), SPPL2b functions as an intramembrane protease that specifically cleaves the transmembrane domain of TNF? Once cleaved, TNF?releases its intracellular domain, a protein that, endosomes and the plasma membrane, is associated with dementia, thus triggering the immunity-related expression of cytokines (also known as interleukins) which are used in various pathways throughout the body, when mutated, SPPL2b is a 592 amino acid multi-pass membrane protein that contains one protease associated domain and belongs to the GXGD family of aspartic proteases
Purification methodThis antibody was purified via Protein A
Storage conditions 50% glycerol and 0, Store at -20°, 09% sodium azide, C for up to 1 year, Keep the antibody in aqueous buffered solution containing 1% BSA
Synonym names Intramembrane protease 4, Protein SPP-like 2B, SPP2B_HUMAN, SPPL2B, Signal peptide peptidase-like 2B, IMP4
PropertiesC, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by Bioss Primary Unconjugated Antibodies they should be stored frozen at - 24°
Gene targetIMP4/SPPL2B
Short nameIMP4/SPPL2B Antibody
Technique antibodies against human proteins, antibodies for, Antibody
Alternative nameIMP4/SPPL2B (Antibody to)
Alternative techniqueantibodies
Identity 30856
Gene IMP4
Long gene name IMP4 homolog, U3 small nucleolar ribonucleoprotein
Synonyms gene name IMP4, U3 small nucleolar ribonucleoprotein, U3 small nucleolar ribonucleoprotein , homolog (yeast) IMP4
Synonyms MGC19606 BXDC4
Locus 2q21, 1
Discovery year 2005-02-21
GenBank acession BC010042
Entrez gene record 92856
Pubmed identfication 8619474 9110174 12655004
RefSeq identity NM_033416
Havana BLAST/BLAT OTTHUMG00000131627

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