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INPPL1 Antibody, Cy5 Conjugated

INPPL1 Antibody, Cy5 Conjugated size: 0.1ml 350

Supplier BIOSS PRIMARY CONJUGATED ANTIBODIES 1
Price 350
Size 0.1ml
Contact us Ask Component cell markers and DNA bp. markers are genetic markerser genes or DNA sequenceswith selection audit
Long name Cy5 Conjugated, INPPL1 Polyclonal Antibody
CategoryConjugated Primary Antibodies
Conjugation5, Cy5
Host OrganismRabbit (Oryctolagus cuniculus)
Target AntigenINPPL1
SpecificityThis is a highly specific antibody against INPPL1
ModificationUnmodified
Modification siteNone
ClonalityPolyclonal
ClonePolyclonal antibody
Concentration1ug per 1ul
Immunogen_range715-765/1258
Subcellular location Cell membrane, Cytoplasm
SourceKLH conjugated synthetic peptide derived from human INPPL1
Gene ID number3636
Swiss ProtO15357
Tested applicationsIF(IHC-P)
Recommended dilutionsIF(IHC-P)(1:50-200)
Crossreactivity Mouse, Rat, Human
Crossreactive species details not every possible cross-reactivity is known, Due to limited amount of testing and knowledge
Antigen background Acts as a negative regulator of EPHA2 receptor endocytosis by inhibiting via PI3K-dependent Rac1 activation, Acts as a negative regulator of the FC-gamma-RIIA receptor (FCGR2A), Acts as a regulator of neuritogenesis by regulating PtdIns(3, Confers resistance to dietary obesity, Involved in EGF signaling pathway, May act by regulating AKT2, Mediates signaling from the FC-gamma-RIIB receptor (FCGR2B), Part of a signaling pathway that regulates actin cytoskeleton remodeling, Participates in regulation of cortical and submembraneous actin by hydrolyzing PtdIns(3, Plays a central role in regulation of PI3K-dependent insulin signaling, Plays a negative role in regulating the PI3K-PKB pathway, Regulates cell adhesion and cell spreading, Required for HGF-mediated lamellipodium formation, Required for the maintenance and dynamic remodeling of actin structures as well as in endocytosis, Upon stimulation by EGF, While overexpression reduces both insulin-stimulated MAP kinase and Akt activation, although the precise molecular mechanisms and signaling pathways remain unclear, and later, but not AKT1, cell scattering and spreading, having a major impact on ligand-induced EGFR internalization and degradation, it is recruited by EGFR and dephosphorylates PtdIns(3, its absence does not affect insulin signaling or GLUT4 trafficking, maintain proper neurite outgrowth, phosphorylation at the plasma membrane, playing a central role in terminating signal transduction from activating immune/hematopoietic cell receptor systems, possibly by inhibiting PKB activity, thereby negatively regulating the PI3K (phosphoinositide 3-kinase) pathways, 4, 4, 4, 4, 4, 4)P2, 5)P3, 5)P3 level and is required to form an initial protrusive pattern, 5)P3 thereby regulating membrane ruffling, 5)P3) to produce PtdIns(3, 5-trisphosphate (PtdIns(3, Phosphatidylinositol (PtdIns) phosphatase that specifically hydrolyzes the 5-phosphate of phosphatidylinositol-3
Purification methodThis antibody was purified via Protein A
Storage conditions 50% glycerol and 0, Store refrigerated at 2 to 8 degrees Celcius for up to 1 year, 09% sodium azide, Keep the antibody in an aqueous buffered solution containing 1% BSA
Excitation Emission625, 650nm/670nm
Synonyms SHIP2
Properties Cy5 antibodies are excited by the 650-nanometer wave of an argon laser and detected at a 670-nanometer captor, C, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by Bioss Primary Conjugated Antibodies they should be stored frozen at - 24°
Gene targetINPPL1 Conjugated
Short name Conjugated, INPPL1 Antibody
Technique antibodies against human proteins, antibodies for, antibody Conjugates, Antibody
LabelCy5
Alternative name cyanine 5 coupled, inositol polyphosphate phosphatase-like 1 (Antibody to)
Alternative techniqueantibodies
Alternative to gene target INPPL1 and IDBG-63291 and ENSG00000165458 and 3636, INPPL1 and IDBG-635082 and ENSBTAG00000019167 and 783833, Inppl1 and IDBG-202184 and ENSMUSG00000032737 and 16332, OPSMD and SHIP2, Plasma membranes, SH2 domain binding, this GO :0001958 and endochondral ossification and biological process this GO :0002376 and immune system process and biological process this GO :0003779 and actin binding and molecular function this GO :0005515 and protein binding and molecular function this GO :0005737 and cytoplasm and cellular component this GO :0005794 and this GO lgi apparatus and cellular component this GO :0005829 and cytosol and cellular component this GO :0005856 and cytoskeleton and cellular component this GO :0005886 and plasma membrane and cellular component this GO :0006006 and glucose metabolic process and biological process this GO :0006644 and phospholipid metabolic process and biological process this GO :0006661 and phosphatidylinositol biosynthetic process and biological process this GO :0006897 and endocytosis and biological process this GO :0007015 and actin filament organization and biological process this GO :0007155 and cell adhesion and biological process this GO :0008285 and negative regulation of cell proliferation and biological process this GO :0009791 and post-embryonic development and biological process this GO :0010629 and negative regulation of gene expression and biological process this GO :0016787 and hydrolase activity and molecular function this GO :0017124 and SH3 domain binding and molecular function this GO :0030027 and lamellipodium and cellular component this GO :0030175 and filopodium and cellular component this GO :0032868 and response to insulin and biological process this GO :0042169 and SH2 domain binding and molecular function this GO :0043647 and inositol phosphate metabolic process and biological process this GO :0044255 and cellular lipid metabolic process and biological process this GO :0044281 and small molecule metabolic process and biological process this GO :0046856 and phosphatidylinositol dephosphorylation and biological process this GO :0097178 and ruffle assembly and biological process, this GO :0003779: actin binding, this GO :0003779: actin binding and also this GO :0005515: protein binding and also this GO :0016787: hydrolase activity and also this GO :0017124: SH3 domain binding and also this GO :0042169: SH2 domain binding, this GO :0005515: protein binding, this GO :0016787: hydrolase activity, this GO :0017124: SH3 domain binding, this GO :0042169: SH2 domain binding, inositol polyphosphate phosphatase-like 1
Identity 6080
Gene INPPL1
Long gene name inositol polyphosphate phosphatase like 1
Synonyms name 51C protein SH2 domain-containing inositol 5', -phosphatase 2 phosphatidylinositol 3, 4, 5-trisphosphate 5-phosphatase 2
Locus 11q13, 4
Discovery year 1995-05-12
GenBank acession Y14385
Entrez gene record 3636
Pubmed identfication 8530088
RefSeq identity NM_001567
Classification Phosphoinositide phosphatases Sterile alpha motif domain containing SH2 domain containing
Havana BLAST/BLAT OTTHUMG00000167879

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