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Insulin Receptor Antibody, HRP Conjugated

Insulin Receptor Antibody, HRP Conjugated size: 0.1ml 350

Supplier BIOSS PRIMARY CONJUGATED ANTIBODIES 1
Price 350
Size 0.1ml
Contact us Ask Component cell markers and DNA bp. markers are genetic markerser genes or DNA sequenceswith selection audit
Long name HRP Conjugated, Insulin Receptor Polyclonal Antibody
CategoryConjugated Primary Antibodies
ConjugationHRP Conjugated
Host OrganismRabbit (Oryctolagus cuniculus)
Target AntigenInsulin Receptor
SpecificityThis is a highly specific antibody against Insulin Receptor
ModificationUnmodified
Modification siteNone
ClonalityPolyclonal
ClonePolyclonal antibody
Concentration1ug per 1ul
Immunogen_range50-100/1382
Subcellular locationExtracellular
SourceKLH conjugated synthetic peptide derived from human Insulin Receptor
Gene ID number3643
Swiss ProtP06213
Tested applications IHC-P, WB
Recommended dilutions IHC-P(1:100-500), WB(1:100-1000)
Crossreactivity Mouse, Rat, Human
Crossreactive species details not every possible cross-reactivity is known, Due to limited amount of testing and knowledge
Antigen background 2, 3, 4, 4), 5)-triphosphate (PIP3), AKT mediates insulin-stimulated protein synthesis by phosphorylating TSC2 thereby activating mTORC1 pathway, Another pathway regulated by PI3K-AKT/PKB activation is mTORC1 signaling pathway which regulates cell growth and metabolism and integrates signals from insulin, Binding of insulin leads to phosphorylation of several intracellular substrates, Binding of the SH2 domains of PI3K to phosphotyrosines on IRS1 leads to the activation of PI3K and the generation of phosphatidylinositol-(3, CBL and other signaling intermediates, Each of these phosphorylated proteins serve as docking proteins for other signaling proteins that contain Src-homology-2 domains (SH2 domain) that specifically recognize different phosphotyrosines residues, GAB1, Moreover, Phosphorylation of IRSs proteins lead to the activation of two main signaling pathways: the PI3K-AKT/PKB pathway, SHC, The net effect of this pathway is to produce a translocation of the glucose transporter SLC2A4/GLUT4 from cytoplasmic vesicles to the cell membrane to facilitate glucose transport, a lipid second messenger, activated AKT/PKB is responsible for: anti-apoptotic effect of insulin by inducing phosphorylation of BAD, and the Ras-MAPK pathway, including, including the p85 regulatory subunit of PI3K and SHP2, insulin receptor substrates (IRS1, regulates the expression of gluconeogenic and lipogenic enzymes by controlling the activity of the winged helix or forkhead (FOX) class of transcription factors, such as PDPK1 and subsequently AKT/PKB, upon insulin stimulation, which activates several PIP3-dependent serine/threonine kinases, which is responsible for most of the metabolic actions of insulin, which regulates expression of some genes and cooperates with the PI3K pathway to control cell growth and differentiation, Receptor tyrosine kinase which mediates the pleiotropic actions of insulin
Purification methodThis antibody was purified via Protein A
Storage conditions 50% glycerol and 0, Store refrigerated at 2 to 8 degrees Celcius for up to 1 year, 09% Gentamicin, Keep the antibody in an aqueous buffered solution containing 1% BSA
Excitation EmissionN/A
Synonyms CD220, INSR, IR, Insulin receptor, HHF5
Properties Also monoclonal HRP conjugates are often used for Western Blot, HRP conjugates are often primary rabbit polyclonal antibodies couples to the , found in the roots of , (HRP), C, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by Bioss Primary Conjugated Antibodies they should be stored frozen at - 24°, enzyme , horseradish, horseradish peroxidase 
Gene targetInsulin Receptor Conjugated
Short name Conjugated, Insulin Receptor Antibody
Technique antibodies against human proteins, antibodies for, antibody Conjugates, Antibody
LabelHRP
Alternative name horseradish peroxidase coupled, Insulin Receptor (Antibody to)
Alternative techniqueantibodies

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