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Insulin Receptor Beta (Tyr1185) Antibody, Cy7 Conjugated

Insulin Receptor Beta (Tyr1185) Antibody, Cy7 Conjugated size: 0.1ml 368

Supplier BIOSS PRIMARY CONJUGATED ANTIBODIES 1
Price 368
Size 0.1ml
Contact us Ask Component cell markers and DNA bp. markers are genetic markerser genes or DNA sequenceswith selection audit
Long name Cy7 Conjugated, Insulin Receptor Beta (Tyr1185) Antibody
CategoryConjugated Primary Antibodies
ConjugationCy7
Host OrganismRabbit (Oryctolagus cuniculus)
Target AntigenInsulin Receptor Beta Tyr1185
SpecificityThis is a highly specific antibody against Insulin Receptor Beta Tyr1185
ModificationPhosphorylation
Modification siteTyr1185
ClonalityPolyclonal
ClonePolyclonal antibody
Concentration1ug per 1ul
Immunogen_range1160-1200/1382
Subcellular locationCell membrane
SourceKLH conjugated synthetic phosphopeptide derived from human INSR around the phosphorylation site of Tyr1185 [DI(p-Y)ET]
Gene ID number3643
Swiss ProtP06213
Tested applicationsIF(IHC-P)
Recommended dilutionsIF(IHC-P)(1:50-200)
Crossreactivity Mouse, Rat, Human
Crossreactive species details not every possible cross-reactivity is known, Due to limited amount of testing and knowledge
Antigen background IRS1, IRS2 and Shc, RTKs are essential components of signal transduction pathways that affect cell proliferation, RTKs are single pass transmembrane receptors that possess intrinsic cytoplasmic enzymatic activity, Receptor activation occurs through ligand binding, The beta subunit (95 kDa) possesses a single transmembrane domain, The insulin receptor exhibits receptor tyrosine kinase (RTK) activity, The interaction of insulin with the alpha subunit of the insulin receptor activates the protein tyrosine kinase of the beta subunit, These three phosphorylated proteins then interact with SH2 domain containing signaling proteins, Three adapter proteins, become phosphorylated on tyrosine residues following insulin receptor activation, catalyzing the transfer of the gamma phosphate of ATP to tyrosine residues in protein substrates, differentiation, fibroblast growth factor and vascular endothelial growth factor, migration and metabolism, whereas the alpha subunit (135 kDa) is completely extracellular, which facilitates receptor dimerization and autophosphorylation of specific tyrosine residues in the cytoplasmic portion, which then undergoes an autophosphorylation that increases its tyrosine kinase activity, Included in this large protein family are the insulin receptor and the receptors for growth factors such as epidermal growth factor, The human insulin receptor is a heterotetrameric membrane glycoprotein consisting of disulfide linked subunits in a beta-alpha-alpha-beta configuration
Purification methodThis antibody was purified via Protein A
Storage conditions 50% glycerol and 0, Store refrigerated at 2 to 8 degrees Celcius for up to 1 year, 09% sodium azide, Keep the antibody in an aqueous buffered solution containing 1% BSA
Excitation Emission743nm/767nm
Synonyms CD22, INSR, IR, Insulin receptor, HHF5
PropertiesC, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by Bioss Primary Conjugated Antibodies they should be stored frozen at - 24°
ConjugatedThese antibodies are excite for emission at 650 nm and detected at a 676 nm wavelengths
Gene targetInsulin Receptor Beta (Tyr1185) Conjugated
Short name Conjugated, Insulin Receptor Beta (Tyr1185) Antibody
Technique antibodies against human proteins, antibodies for, antibody Conjugates, Antibody
LabelCy7
Alternative name cyanine 7 coupled, Insulin Receptor b (Tyr1185) (Antibody to)
Alternative techniqueantibodies

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