| Alternative name1 | ERN1, Endoplasmic Reticulum-to-Nucleus Signaling 1, FLJ30999, IRE1 alpha, IRE1a, Serine/Threonine Protein Kinase/Endoribonuclease IRE1), phosphorylated (Ser724) (Inositol-Requiring Protein 1, Anti-IRE1p |
| Alternative name2 | ERN1, Endoplasmic Reticulum-to-Nucleus Signaling 1, FLJ30999, IRE1 alpha, IRE1a, Serine/Threonine Protein Kinase/Endoribonuclease IRE1), phosphorylated (Ser724) (Inositol-Requiring Protein 1, IRE1p |
| Alternative name3 | ERN1, Endoplasmic Reticulum-to-Nucleus Signaling 1, FLJ30999, IRE1 alpha, IRE1a, Serine/Threonine Protein Kinase/Endoribonuclease IRE1), phosphorylated (Ser724) (Inositol-Requiring Protein 1, IRE1p |
| Alternative name4 | IRE1p |
| Alternative name5 | ERN1, Endoplasmic Reticulum-to-Nucleus Signaling 1, FLJ30999, IRE1 alpha, IRE1a, Serine/Threonine Protein Kinase/Endoribonuclease IRE1), phosphorylated (Ser724) (Inositol-Requiring Protein 1, Anti -IRE1p |
| Other names | Endoplasmic reticulum-to-nucleus signaling 1, Ire1p, N/A, Serine/threonine-protein kinase/endoribonuclease IRE1, Ire1p |
| Gene name | N/A |
| Gene name synonims | N/A |
| Other gene names | ERN1, ERN1, IRE1, IRE1 |
| Category | Antibodies |
| Clonality | Polyclonal |
| Immunoglobulin isotype | IgG |
| Clone | Polyclonal antibody |
| Host organism | Source: Human, Host: Rabbit |
| Species reactivity | Mouse, Rat, Human |
| Specificity and cross-reactivity | Does not react with monkey, Species Crossreactivity: rat and mouse, phosphorylated (Ser724) at~110kD, Recognizes human IRE1p |
| Purification method | Affinity Purified by immunoaffinity chromatography |
| Form/Appearance | 0, 30% glycerol, 1% sodium azide, Supplied as a liquid in PBS |
| Concentration | N/A |
| Storage and shipping | Aliquot to avoid repeated freezing and thawing, Aliquots are stable for 12 months, For maximum recovery of product, For optimal long term storage, centrifuge the original vial after thawing and prior to removing the cap, productone should be kept at -20 degrees Celsius, Store at 4 degrees Celsius for short term storage |
| Tested for: | Western Blot (WB) |
| Description | By understanding cell signaling, Errors in cellular information processing are responsible for diseases such as cancer, The ability of cells to perceive and correctly respond to their microenvironment is the basis of development, and diabetes, and immunity as well as normal tissue homeostasis, artificial tissues may be created, autoimmunity, diseases may be treated effectively and, theoretically, tissue repair, Cell nucleus signaling proteins and molecules are part of a complex system of communication that governs basic cellular activities and coordinates cell actions |
| Advisory | For antibodies that are in liquid form or reconstituted lyophilized antibodies small amounts could become entrapped on the seal or the walls of the tube, Prior to use briefly centrifuge the vial to gather all the solution on the bottom, avoid cycles of freezing and thawing, please, In order to retain the quality and the affinity of productone unchanged |
| Properties | C, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by MBS Polyclonals_1 they should be stored frozen at - 24° |
| Gene target | ERN1, Endoplasmic Reticulum Nucleus Signaling 1, FLJ30999, IRE1 alpha, IRE1a, Serine/Threonine Protein Kinase/Endoribonuclease IRE1), phosphorylated (Ser724) (Inositol-Requiring Protein 1, IRE1p |
| Short name | ERN1, Endoplasmic Reticulum- -Nucleus Signaling 1, FLJ30999, IRE1 alpha, IRE1a, Serine/Threonine Protein Kinase/Endoribonuclease IRE1) Antibody, phosphorylated (Ser724) (Inositol-Requiring Protein 1, IRE1p |
| Technique | antibodies against human proteins, antibodies for, Antibody |
| Alternative name | Endoplasmic Reticulum-to-Nucleus Signaling 1, FLJ30999, IRE1 a, IRE1a, Serine/Threonine Protein phosphorylation catalyst/Endoribonuclease IRE1) (Antibody to), endoplasmic reticulum to nucleus signaling 1, phosphorylated (Ser724) (Inositol-Requiring Protein 1, IRE1p |
| Alternative technique | antibodies |
| Alternative to gene target | DNA-templated and biological process this GO :0006355 and regulation of transcription, DNA-templated and biological process this GO :0006397 and mRNA processing and biological process this GO :0006468 and protein phosphorylation and biological process this GO :0006987 and activation of signaling protein activity involved in unfolded protein response and biological process this GO :0007050 and cell cycle arrest and biological process this GO :0016772 and transferase activity, ERN1 and IDBG-641835 and ENSBTAG00000016799 and 524719, ERN1 and IDBG-64539 and ENSG00000178607 and 2081, Ern1 and IDBG-213476 and ENSMUSG00000020715 and 78943, endonucleolytic and biological process this GO :1900103 and positive regulation of endoplasmic reticulum unfolded protein response and biological process, hIRE1p and IRE1 and IRE1a and IRE1P, nuclei, this GO :0000287 and magnesium ion binding and molecular function this GO :0004519 and endonuclease activity and molecular function this GO :0004521 and endoribonuclease activity and molecular function this GO :0004540 and ribonuclease activity and molecular function this GO :0004672 and protein kinase activity and molecular function this GO :0004674 and protein serine/threonine kinase activity and molecular function this GO :0004713 and protein tyrosine kinase activity and molecular function this GO :0005515 and protein binding and molecular function this GO :0005524 and ATP binding and molecular function this GO :0005637 and nuclear inner membrane and cellular component this GO :0005739 and mitochondrion and cellular component this GO :0005789 and endoplasmic reticulum membrane and cellular component this GO :0006351 and transcription, this GO :0000287: magnesium ion binding, this GO :0000287: magnesium ion binding and also this GO :0004519: endonuclease activity and also this GO :0004521: endoribonuclease activity and also this GO :0004540: ribonuclease activity and also this GO :0004672: protein kinase activity and also this GO :0004674: protein serine/threonine kinase activity and also this GO :0004713: protein tyrosine kinase activity and also this GO :0005515: protein binding and also this GO :0005524: ATP binding and also this GO :0016772: transferase activity, this GO :0004519: endonuclease activity, this GO :0004521: endoribonuclease activity, this GO :0004540: ribonuclease activity, this GO :0004672: protein kinase activity, this GO :0004674: protein serine/threonine kinase activity, this GO :0004713: protein tyrosine kinase activity, this GO :0005515: protein binding, this GO :0005524: ATP binding, this GO :0016772: transferase activity, this GO :0019899: enzyme binding, this GO :0042802: identical protein binding, transferase activity, transferring phosphorus-containing groups, transferring phosphorus-containing groups and also this GO :0019899: enzyme binding and also this GO :0042802: identical protein binding, transferring phosphorus-containing groups and molecular function this GO :0019899 and enzyme binding and molecular function this GO :0030176 and integral component of endoplasmic reticulum membrane and cellular component this GO :0030968 and endoplasmic reticulum unfolded protein response and biological process this GO :0042802 and identical protein binding and molecular function this GO :0044267 and cellular protein metabolic process and biological process this GO :0045087 and innate immune response and biological process this GO :0046777 and protein autophosphorylation and biological process this GO :0070055 and HAC1-type intron splice site recognition and cleavage and biological process this GO :0070059 and intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress and biological process this GO :0090305 and nucleic acid phosphodiester bond hydrolysis and biological process this GO :0090502 and RNA phosphodiester bond hydrolysis, endoplasmic reticulum to nucleus signaling 1 |
| Identity | 3449 |
| Gene | ERN1 |
| Long gene name | endoplasmic reticulum to nucleus signaling 1 |
| Synonyms gene name | ER to nucleus signalling 1 |
| Synonyms | IRE1 IRE1P |
| Synonyms name | inositol-requiring enzyme 1 Serine/threonine-protein kinase/endoribonuclease IRE1 |
| Locus | 17q23, 3 |
| Discovery year | 1998-08-06 |
| GenBank acession | AF059198 |
| Entrez gene record | 2081 |
| Pubmed identfication | 9637683 |
| RefSeq identity | NM_001433 |
| Havana BLAST/BLAT | OTTHUMG00000178879 |
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