| Long name | IRF6 Primary Polyclonal Antibody |
| Also known as | IRF6 PAb |
| Category | Primary Antibodies |
| Conjugation | Unconjugated |
| Target Antigen | IRF6 |
| Specificity | This is a highly specific antibody against IRF6 |
| Modification(s) | None |
| Modification site(s) | Unmodified antibody |
| Clonality | Polyclonal antibody |
| Clone number | Polyclonal antibody |
| Concentration | 1ug per 1ul |
| Source | This antibody was obtained by immunization of the host with KLH conjugated synthetic peptide derived from human IRF6 |
| Tested Applications | IF(IHC-P), IHC-P, WB |
| Recommended dilutions | IF(IHC-P)(1:50-200), IHC-P(1:100-500), WB(1:100-1000) |
| Cross reactivity | Mouse, Rat, Human |
| Cross reactive species details | not every possible cross-reactivity is known, Due to limited amount of testing and knowledge |
| Background of the target antigen | IRF-1 and IRF-2 are members of a larger family of DNA binding proteins that includes IRF-3, IRF-1 and IRF-2 have been reported to act in a mutually antagonistic manner in regulating cell growth, IRF-1 functions as an activator of interferon transcription, IRF-4, IRF-5, IRF-6, IRF-7, ISGF-3 gamma p48 and IFN consensus sequence-binding protein (ICSBP), In addition, The two factors are structurally related, both bind to the same sequence within the promoters of interferon-alpha and interferon-beta genes, overexpression of the repressor IRF-2 leads to cell transformation while concomitant overexpression of IRF-1 causes reversion, particularly in their N-terminal regions, which confer DNA binding specificity, while IRF-2 binds to the same cis elements and represses IRF-1 action, Interferon regulatory factor-1 (IRF-1) and IRF-2 have been identified as novel DNA-binding factors that function as regulators of both type I interferon (interferon-alpha and beta) and interferon-inducible genes |
| Purification method | This antibody was purified via Protein A |
| Storage conditions | 50% glycerol and 0, Store at -20°, 09% sodium azide, C for up to 1 year, Keep the antibody in aqueous buffered solution containing 1% BSA |
| Synonym names | IRF 6, IRF-6, IRF6, IRF6_HUMAN, LPS, OFC 6, OFC6, OTTHUMP00000034677, OTTHUMP00000034678, PIT, PPS, PPS1, VWS, VWS1, Interferon regulatory factor 6 |
| Properties | C, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by Bioss Primary Unconjugated Antibodies they should be stored frozen at - 24° |
| Gene target | IRF6 |
| Short name | IRF6 Antibody |
| Technique | antibodies against human proteins, antibodies for, Antibody |
| Alternative name | interferon regulatory factor 6 (Antibody to) |
| Alternative technique | antibodies |
| Alternative to gene target | DNA-templated and biological process this GO :0006355 and regulation of transcription, DNA-templated and biological process this GO :0007050 and cell cycle arrest and biological process this GO :0008285 and negative regulation of cell proliferation and biological process this GO :0019221 and cytokine-mediated signaling pathway and biological process this GO :0030216 and keratinocyte differentiation and biological process this GO :0043588 and skin development and biological process this GO :0043616 and keratinocyte proliferation and biological process this GO :0045087 and innate immune response and biological process this GO :0045893 and positive regulation of transcription, DNA-templated and biological process this GO :0048468 and cell development and biological process this GO :0060333 and interferon-gamma-mediated signaling pathway and biological process this GO :0060337 and type I interferon signaling pathway and biological process this GO :0060644 and mammary gland epithelial cell differentiation and biological process this GO :0070062 and extracellular vesicular exosome and cellular component, IRF6 and IDBG-106452 and ENSG00000117595 and 3664, IRF6 and IDBG-638354 and ENSBTAG00000002849 and 614253, Irf6 and IDBG-209073 and ENSMUSG00000026638 and 54139, LPS and OFC6 and PIT and PPS and PPS1 and VWS and VWS1, nuclei, protein binding, this GO :0000975 and regulatory region DNA binding and molecular function this GO :0003677 and DNA binding and molecular function this GO :0003700 and sequence-specific DNA binding transcription factor activity and molecular function this GO :0005515 and protein binding and molecular function this GO :0005634 and nucleus and cellular component this GO :0005737 and cytoplasm and cellular component this GO :0005829 and cytosol and cellular component this GO :0006351 and transcription, this GO :0000975: regulatory region DNA binding, this GO :0000975: regulatory region DNA binding and also this GO :0003677: DNA binding and also this GO :0003700: sequence-specific DNA binding transcription factor activity and also this GO :0005515: protein binding, this GO :0003677: DNA binding, this GO :0003700: sequence-specific DNA binding transcription factor activity, this GO :0005515: protein binding, interferon regulatory factor 6 |
| Identity | 6121 |
| Gene | IRF6 |
| Long gene name | interferon regulatory factor 6 |
| Synonyms gene | VWS LPS |
| Synonyms gene name | Van der Woude syndrome |
| Synonyms | OFC6 VWS1 |
| Locus | 1q32, 2 |
| Discovery year | 1997-10-16 |
| GenBank acession | AL022398 |
| Entrez gene record | 3664 |
| Pubmed identfication | 12219090 |
| RefSeq identity | NM_006147 |
| Havana BLAST/BLAT | OTTHUMG00000036521 |
Technique
Supplier
Species
Label
Iso Type
Host
Tissue