| Long name | IRS1(Ser636 + Ser639) Antibody |
| Also known as | IRS1(Ser636 + Ser639) Antibody |
| Category | Primary Antibodies |
| Conjugation | Unconjugated |
| Target Antigen | IRS1 Ser636 + Ser639 |
| Specificity | Ser675 + Ser678 in Mouse, This phosphorylation site is homologous to Ser632 + ser635 in Mouse and Rat IRS1, This protein is known to be highly conserved in this sequences region, and Ser676 +Ser679 in Rat based on homology, this antibody may react with IRS2 when phosphorylated at Ser679 + Ser682 in Human , thus , This is a highly specific antibody against IRS1 Ser636 + Ser639 |
| Modification(s) | Phosphorylation |
| Modification site(s) | Ser636 + Ser639 |
| Clonality | Polyclonal antibody |
| Clone number | Polyclonal antibody |
| Concentration | 1ug per 1ul |
| Immunogen range | 610-660/1242 |
| Subcellular location | Membrane bound, Nucleus, Cytoplasm |
| Source | KLH conjugated synthetic phosphopeptide derived from human IRS1 around the phosphorylation site of Ser636/639 [PM(p-S)PK(p-S)VS] |
| Gene ID number | 3667 |
| Swiss Prot | P35568 |
| Tested Applications | IF(IHC-P), IHC-P, WB |
| Recommended dilutions | IF(IHC-P)(1:50-200), IHC-P(1:100-500), WB(1:100-1000) |
| Cross reactivity | Mouse, Rat, Human |
| Cross reactive species details | not every possible cross-reactivity is known, Due to limited amount of testing and knowledge |
| Background of the target antigen | Activates phosphatidylinositol 3-kinase when bound to the regulatory p85 subunit (By similarity), When phosphorylated by the insulin receptor binds specifically to various cellular proteins containing SH2 domains such as phosphatidylinositol 3-kinase p85 subunit or GRB2, May mediate the control of various cellular processes by insulin |
| Purification method | This antibody was purified via Protein A |
| Storage conditions | 50% glycerol and 0, Store at -20°, 09% sodium azide, C for up to 1 year, Keep the antibody in aqueous buffered solution containing 1% BSA |
| Synonym names | IRS-1, IRS1, Insulin receptor substrate 1, HIRS-1 |
| Properties | C, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by Bioss Primary Unconjugated Antibodies they should be stored frozen at - 24° |
| Gene target | IRS1(Ser636 + Ser639) |
| Short name | IRS1(Ser636 + Ser639) Antibody |
| Technique | antibodies against human proteins, antibodies for, Antibody |
| Alternative name | insulin receptor substrate 1(Ser636 and Ser639) (Antibody to) |
| Alternative technique | antibodies |
| Alternative to gene target | HIRS-1, IRS1 and IDBG-647770 and ENSBTAG00000021308 and 538598, IRS1 and IDBG-82407 and ENSG00000169047 and 3667, Irs1 and IDBG-173589 and ENSMUSG00000055980 and 16367, nuclei, phosphatidylinositol 3-kinase binding, this GO :0002053 and positive regulation of mesenchymal cell proliferation and biological process this GO :0004871 and signal transducer activity and molecular function this GO :0005068 and transmembrane receptor protein tyrosine kinase adaptor activity and molecular function this GO :0005080 and protein kinase C binding and molecular function this GO :0005158 and insulin receptor binding and molecular function this GO :0005159 and insulin-like growth factor receptor binding and molecular function this GO :0005515 and protein binding and molecular function this GO :0005634 and nucleus and cellular component this GO :0005737 and cytoplasm and cellular component this GO :0005829 and cytosol and cellular component this GO :0005886 and plasma membrane and cellular component this GO :0005899 and insulin receptor complex and cellular component this GO :0005901 and caveola and cellular component this GO :0007165 and signal transduction and biological process this GO :0007173 and epidermal growth factor receptor signaling pathway and biological process this GO :0008284 and positive regulation of cell proliferation and biological process this GO :0008286 and insulin receptor signaling pathway and biological process this GO :0008543 and fibroblast growth factor receptor signaling pathway and biological process this GO :0010468 and regulation of gene expression and biological process this GO :0010907 and positive regulation of glucose metabolic process and biological process this GO :0014065 and phosphatidylinositol 3-kinase signaling and biological process this GO :0016042 and lipid catabolic process and biological process this GO :0019901 and protein kinase binding and molecular function this GO :0030335 and positive regulation of cell migration and biological process this GO :0030879 and mammary gland development and biological process this GO :0032000 and positive regulation of fatty acid beta-oxidation and biological process this GO :0032868 and response to insulin and biological process this GO :0032869 and cellular response to insulin stimulus and biological process this GO :0034504 and protein localization to nucleus and biological process this GO :0036064 and ciliary basal body and cellular component this GO :0038095 and Fc-epsilon receptor signaling pathway and biological process this GO :0042169 and SH2 domain binding and molecular function this GO :0042593 and glucose homeostasis and biological process this GO :0043231 and intracellular membrane-bounded organelle and cellular component this GO :0043434 and response to peptide hormone and biological process this GO :0043491 and protein kinase B signaling and biological process this GO :0043548 and phosphatidylinositol 3-kinase binding and molecular function this GO :0043552 and positive regulation of phosphatidylinositol 3-kinase activity and biological process this GO :0045087 and innate immune response and biological process this GO :0045725 and positive regulation of glycogen biosynthetic process and biological process this GO :0046326 and positive regulation of glucose import and biological process this GO :0046627 and negative regulation of insulin receptor signaling pathway and biological process this GO :0046628 and positive regulation of insulin receptor signaling pathway and biological process this GO :0046676 and negative regulation of insulin secretion and biological process this GO :0048009 and insulin-like growth factor receptor signaling pathway and biological process this GO :0048011 and neurotrophin TRK receptor signaling pathway and biological process this GO :0048015 and phosphatidylinositol-mediated signaling and biological process this GO :0060397 and JAK-STAT cascade involved in growth hormone signaling pathway and biological process this GO :2001275 and positive regulation of glucose import in response to insulin stimulus and biological process, this GO :0004871: signal transducer activity, this GO :0004871: signal transducer activity and also this GO :0005068: transmembrane receptor protein tyrosine kinase adaptor activity and also this GO :0005080: protein kinase C binding and also this GO :0005158: insulin receptor binding and also this GO :0005159: insulin-like growth factor receptor binding and also this GO :0005515: protein binding and also this GO :0019901: protein kinase binding and also this GO :0042169: SH2 domain binding and also this GO :0043548: phosphatidylinositol 3-kinase binding, this GO :0005068: transmembrane receptor protein tyrosine kinase adaptor activity, this GO :0005080: protein kinase C binding, this GO :0005158: insulin receptor binding, this GO :0005159: insulin-like growth factor receptor binding, this GO :0005515: protein binding, this GO :0019901: protein kinase binding, this GO :0042169: SH2 domain binding, this GO :0043548: phosphatidylinositol 3-kinase binding, insulin receptor substrate 1 |
| Identity | 6125 |
| Gene | IRS1 |
| Long gene name | insulin receptor substrate 1 |
| Synonyms | HIRS-1 |
| Locus | 2q36, 3 |
| Discovery year | 1992-08-24 |
| Entrez gene record | 3667 |
| Pubmed identfication | 1648180 |
| RefSeq identity | NM_005544 |
| Classification | Pleckstrin homology domain containing |
| Havana BLAST/BLAT | OTTHUMG00000133179 |
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