ISG15 (1031CT2.8.3) Monoclonal Antibody

ISG15 (1031CT2.8.3) Monoclonal Antibody size: 0.1ml 281

Supplier BIOSS PRIMARY UNCONJUGATED ANTIBODIES

Price 281

Size 0.1ml

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Long name	3) Monoclonal Antibody, 8, ISG15 (1031CT2
Also known as	3) Monoclonal Antibody, 8, ISG15 (1031CT2
Category	Primary Antibodies
Conjugation	Unconjugated
Target Antigen	ISG15
Specificity	This is a highly specific antibody against ISG15
Modification(s)	None
Modification site(s)	Unmodified antibody
Clonality	Monoclonal
Clone number	1031CT2, 3, 8
Source	This ISG15 antibody is generated from a mouse immunized with a KLH conjugated synthetic peptide between 1-165 amino acids from the N-terminal region of human ISG15
Gene ID number	9636
Swiss Prot	P05161
Tested Applications	WB
Recommended dilutions	WB(1:2000-8000)
Cross reactivity	Human
Cross reactive species details	not every possible cross-reactivity is known, Due to limited amount of testing and knowledge
Background of the target antigen	CHMP2A, CHMP4B and CHMP6, CHMP5, Can also isgylate: EIF2AK2/PKR which results in its activation, DDX58/RIG-I which inhibits its function in antiviral signaling response, E2, EIF4E2 which enhances its cap structure-binding activity and translation-inhibition activity, Exhibits antiviral activity towards both DNA and RNA viruses, HIV-1 and Ebola virus, IRF3 which inhibits its ubiquitination and degradation and FLNB which prevents its ability to interact with the upstream activators of the JNK cascade therby inhibiting IFNA-induced JNK signaling, ISGylates influenza A virus NS1 protein which causes a loss of function of the protein and the inhibition of virus replication, ISGylation involves a cascade of enzymatic reactions involving E1, Inhibits Ebola virus budding mediated by the VP40 protein by disrupting ubiquitin ligase activity of NEDD4 and its ability to ubiquitinate VP40, Inhibits the ubiquitination of HIV-1 Gag and host TSG101 and disrupts their interaction, Its target proteins include IFIT1, MX1/MxA, PPM1B, Restricts HIV-1 and ebola virus via disruption of viral budding, The secreted form of ISG15 can: induce natural killer cell proliferation, UBA7, UBE2L6, UBE2N and UBE2E1 which negatively regulates their activity, act as a chemotactic factor for neutrophils and act as a IFN-gamma-inducing cytokine playing an essential role in antimycobacterial immunity, and E3 enzymes which catalyze the conjugation of ISG15 to a lysine residue in the target protein, including influenza A, thereby preventing assembly and release of virions from infected cells, Ubiquitin-like protein which plays a key role in the innate immune response to viral infection either via its conjugation to a target protein (ISGylation) or via its action as a free or unconjugated protein
Purification method	Purified by Protein G
Storage conditions	50% glycerol and 0, Store at -20°, 09% sodium azide, C for up to 1 year, Keep the antibody in aqueous buffered solution containing 1% BSA
Synonym names	IFI15, IMD38, IP17, ISG15, Interferon-induced 15 kDa protein, Interferon-induced 17 kDa protein, UCRP, Ubiquitin cross-reactive protein, Ubiquitin-like protein ISG15, hUCRP, G1P2
Properties	C, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by Bioss Primary Unconjugated Antibodies they should be stored frozen at - 24°
About	Each murine monoclonal anibody has his own affinity specific for the clone, Mouse monoclonal antibodies are purified protein A or G and can be conjugated to FITC for flow cytometry or FACS and can be of different isotypes, Monoclonals of this antigen are available in different clones
Gene target	3) Monoclonal, 8, ISG15 (1031CT2
Short name	3) Monoclonal Antibody, 8, ISG15 (1031CT2
Technique	Monoclonals or monoclonal antibodies, antibodies against human proteins, antibodies for, Antibody
Alternative name	3) monoclonal (Antibody to), 8, ISG15 (1031CT2
Alternative technique	antibodies
Identity	4053
Gene	ISG15
Long gene name	ISG15 ubiquitin-like modifier
Synonyms gene	G1P2
Synonyms gene name	alpha-inducible protein (clone IFI-15K) , interferon
Synonyms	IFI15 UCRP
Locus	1p36, 33
Discovery year	1990-10-16
GenBank acession	BC009507
Entrez gene record	9636
Pubmed identfication	3087979
RefSeq identity	NM_005101
Havana BLAST/BLAT	OTTHUMG00000040777

ISG15 (1031CT2.8.3) Monoclonal Antibody

ISG15 (1031CT2.8.3) Monoclonal Antibody size: 0.1ml 281

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