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ITCH Antibody / AIF4

ITCH Antibody / AIF4 size: 0.1mg 406

Supplier NJS POLY
Price 406
Size 0.1mg
Contact us Ask Component cell markers and DNA bp. markers are genetic markerser genes or DNA sequenceswith selection audit
CategoryAntibody
Concentration2ml sterile DI water, 5mg/ml if reconstituted with 0
FormAntigen affinity purified
ConjugationUnconjugated
ClonePolyclonal antibody
Recognised antigenITCH / AIF4
Host animalRabbit (Oryctolagus cuniculus)
ClonalityPolyclonal (rabbit origin)
Species reactivity Due to limited knowledge and inability to test the antibody against all known species, we cannot guarantee that no other cross reactivity can occur, Human (Homo sapiens)
Tested applicationsWB
Recommended dilutions1-0, 5ug/ml, Western blot: 0
NotesOptimal dilution of the ITCH antibody should be determined by the researcher
Intented useThis ITCH antibodyis to be used only for research purposes and not for diagnostics
Uniprot #Q96J02
PurityAntigen affinity
Description Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene, HECT domain E3 ubiquitin ligases transfer ubiquitin from E2 ubiquitin-conjugating enzymes to protein substrates, Mutations in this gene are a cause of syndromic multisystem autoimmune disease, The encoded protein plays a role in multiple cellular processes including erythroid and lymphoid cell differentiation and the regulation of immune responses, This gene encodes a member of the Nedd4 family of HECT domain E3 ubiquitin ligases, thus targeting specific proteins for lysosomal degradation, ITCH is an ubiquitin-conjugating enzyme
ImmunogenAmino acids AMQQFNQRFIYGNQDLFATSQSKEFDPL of human ITCH were used as the immunogen for the ITCH antibody
Storage Avoid repeated freezing and thawing, Celcius or lower, Cycles of freezing and thawing can denaturate the peptide chains of the antibodies and reduce their sensitivity and/or change their affinity, Prepare aliqotes in such a manner so that freeze-thaw cycles are minimized, aliquot and store at -20 deg, the ITCH antibody may be kept for up to one month refrigerated at +4 degrees C, After reconstitution, For long-term
PropertiesC, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by NJS poly they should be stored frozen at - 24°
Gene targetITCH / AIF4
Short nameITCH Antibody / AIF4
Technique antibodies against human proteins, antibodies for, Antibody
Alternative nameitchy E3 ubiquitin protein ligase (Antibody to) / AIF4
Alternative techniqueantibodies
Alternative to gene target CXCR chemokine receptor binding, ITCH and IDBG-641890 and ENSBTAG00000000308 and 508431, ITCH and IDBG-68143 and ENSG00000078747 and 83737, Itch and IDBG-210517 and ENSMUSG00000027598 and 16396, leucine rich repeat containing receptor signaling pathway and biological process this GO :0042787 and protein ubiquitination involved in ubiquitin-dependent protein catabolic process and biological process this GO :0043021 and ribonucleoprotein complex binding and molecular function this GO :0043066 and negative regulation of apoptotic process and biological process this GO :0045087 and innate immune response and biological process this GO :0045236 and CXCR chemokine receptor binding and molecular function this GO :0045732 and positive regulation of protein catabolic process and biological process this GO :0046329 and negative regulation of JNK cascade and biological process this GO :0046642 and negative regulation of alpha-beta T cell proliferation and biological process this GO :0046718 and viral entry into host cell and biological process this GO :0050687 and negative regulation of defense response to virus and biological process this GO :0051607 and defense response to virus and biological process this GO :0070423 and nucleotide-binding oli this GO merization domain containing signaling pathway and biological process this GO :0070534 and protein K63-linked ubiquitination and biological process this GO :0070936 and protein K48-linked ubiquitination and biological process this GO :0090085 and regulation of protein deubiquitination and biological process, nuclei, this GO :0000209 and protein polyubiquitination and biological process this GO :0001558 and regulation of cell growth and biological process this GO :0002669 and positive regulation of T cell anergy and biological process this GO :0004842 and ubiquitin-protein transferase activity and molecular function this GO :0005515 and protein binding and molecular function this GO :0005634 and nucleus and cellular component this GO :0005737 and cytoplasm and cellular component this GO :0005829 and cytosol and cellular component this GO :0005886 and plasma membrane and cellular component this GO :0005938 and cell cortex and cellular component this GO :0006511 and ubiquitin-dependent protein catabolic process and biological process this GO :0006915 and apoptotic process and biological process this GO :0006954 and inflammatory response and biological process this GO :0007219 and Notch signaling pathway and biological process this GO :0016020 and membrane and cellular component this GO :0016567 and protein ubiquitination and biological process this GO :0016874 and ligase activity and molecular function this GO :0031410 and cytoplasmic vesicle and cellular component this GO :0032088 and negative regulation of NF-kappaB transcription factor activity and biological process this GO :0032480 and negative regulation of type I interferon production and biological process this GO :0035519 and protein K29-linked ubiquitination and biological process this GO :0035872 and nucleotide-binding domain, this GO :0004842: ubiquitin-protein transferase activity, this GO :0004842: ubiquitin-protein transferase activity and also this GO :0005515: protein binding and also this GO :0016874: ligase activity and also this GO :0043021: ribonucleoprotein complex binding and also this GO :0045236: CXCR chemokine receptor binding, this GO :0005515: protein binding, this GO :0016874: ligase activity, this GO :0043021: ribonucleoprotein complex binding, this GO :0045236: CXCR chemokine receptor binding, itchy E3 ubiquitin protein ligase
Identity 13890
Gene ITCH
Long gene name itchy E3 ubiquitin protein ligase
Synonyms gene name itchy (mouse homolog) E3 ubiquitin protein ligase itchy E3 ubiquitin protein ligase homolog (mouse)
Synonyms AIP4
Locus 20q11, 22
Discovery year 2001-04-27
GenBank acession AF095745
Entrez gene record 83737
Pubmed identfication 11318614
Classification C2 domain containing
Havana BLAST/BLAT OTTHUMG00000032300
Locus Specific Databases LRG_354

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