| Long name | 1) Monoclonal Antibody, 4, ITGB1 (1084CT17 |
| Also known as | 1) Monoclonal Antibody, 4, ITGB1 (1084CT17 |
| Category | Primary Antibodies |
| Conjugation | Unconjugated |
| Target Antigen | ITGB1 |
| Specificity | This is a highly specific antibody against ITGB1 |
| Modification(s) | None |
| Modification site(s) | Unmodified antibody |
| Clonality | Monoclonal |
| Clone number | 1, 1084CT17, 4 |
| Source | Purified His-tagged ITGB1 protein was used to produced this monoclonal antibody |
| Gene ID number | 3688 |
| Swiss Prot | P05556 |
| Tested Applications | WB |
| Recommended dilutions | WB(1:1000) |
| Cross reactivity | Human |
| Cross reactive species details | not every possible cross-reactivity is known, Due to limited amount of testing and knowledge |
| Background of the target antigen | Alpha-3/beta-1 may mediate with LGALS3 the stimulation by CSPG4 of endothelial cells migration, Alpha-4/beta-1 recognizes one or more domains within the alternatively spliced CS-1 and CS-5 regions of fibronectin, Beta-1 integrins recognize the sequence R-G-D in a wide array of ligands, In case of HIV-1 infection, Integrin alpha-1/beta-1, Integrin alpha-3/beta-1 is a receptor for epiligrin, Integrin alpha-4/beta-1 is a receptor for VCAM1, Integrin alpha-5/beta-1 is a receptor for fibrinogen, Integrin alpha-9/beta-1 is a receptor for VCAM1, Integrin alpha-V/beta-1 is a receptor for vitronectin, Integrins alpha-1/beta-1 and alpha-2/beta-2 recognize the proline-hydroxylated sequence G-F-P-G-E-R in collagen, Integrins alpha-2/beta-1, Involved in promoting endothelial cell motility and angiogenesis, Isoform beta-1B interferes with isoform beta-1A resulting in a dominant negative effect on cell adhesion and migration (in vitro), It recognizes the sequence A-E-I-D-G-I-E-L in cytotactin, It recognizes the sequence Q-I-D-S in VCAM1, May be involved in up-regulation of the activity of kinases such as PKC via binding to KRT1, Plays a mechanistic adhesive role during telophase, Together with KRT1 and GNB2L1/RACK1, When associated with alpha-7/beta-1 integrin, alpha-10/beta-1, alpha-10/beta-1 and alpha-11/beta-1 are receptors for collagen, alpha-11/beta-1 and alpha-V/beta-1 are receptors for fibronectin, alpha-2/beta-1, alpha-2/beta-1, alpha-3/beta-1, alpha-4/beta-1, alpha-5/beta-1, alpha-6/beta-1 and alpha-7/beta-1 are receptors for lamimin, alpha-8/beta-1, cytotactin and osteopontin, regulates cell adhesion and laminin matrix deposition, required for the successful completion of cytokinesis, serves as a platform for SRC activation or inactivation, the interaction with extracellular viral Tat protein seems to enhance angiogenesis in Kaposi's sarcoma lesions, thrombospondin and CSPG4, Integrins alpha-1/beta-1 |
| Purification method | This antibody is purified through a protein G column, eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS, 09% (W/V) sodium azide, Purified monoclonal antibody supplied in PBS with 0 |
| Storage conditions | 50% glycerol and 0, Store at -20°, 09% sodium azide, C for up to 1 year, Keep the antibody in aqueous buffered solution containing 1% BSA |
| Synonym names | FNRB, Fibronectin receptor subunit beta, GPIIA, Glycoprotein IIa, ITGB1, Integrin beta-1, MDF2, MSK12, VLA-4 subunit beta, VLA-BETA, VLAB, CD29 |
| Properties | C, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by Bioss Primary Unconjugated Antibodies they should be stored frozen at - 24° |
| About | Each murine monoclonal anibody has his own affinity specific for the clone, Mouse monoclonal antibodies are purified protein A or G and can be conjugated to FITC for flow cytometry or FACS and can be of different isotypes, Monoclonals of this antigen are available in different clones |
| Gene target | 1) Monoclonal, 4, ITGB1 (1084CT17 |
| Short name | 1) Monoclonal Antibody, 4, ITGB1 (1084CT17 |
| Technique | Monoclonals or monoclonal antibodies, antibodies against human proteins, antibodies for, Antibody |
| Alternative name | MSK12) (1084CT17, antigen CD29 includes MDF2, b 1 (fibronectin receptor, b polypeptide, 1) monoclonal (Antibody to), 4, integrin |
| Alternative technique | antibodies |
| Alternative to gene target | CD29 and FNRB and GPIIA and MDF2 and MSK12 and VLA-BETA and VLAB, Cell surfaces, ITGB1 and IDBG-637396 and ENSBTAG00000015910 and 281876, ITGB1 and IDBG-68302 and ENSG00000150093 and 3688, Itgb1 and IDBG-201159 and ENSMUSG00000025809 and 16412, MSK12), alpha-actinin binding, antigen CD29 includes MDF2, beta 1 (fibronectin receptor, beta polypeptide, this GO :0000082 and G1/S transition of mitotic cell cycle and biological process this GO :0001618 and virus receptor activity and molecular function this GO :0001669 and acrosomal vesicle and cellular component this GO :0001701 and in utero embryonic development and biological process this GO :0001708 and cell fate specification and biological process this GO :0001726 and ruffle and cellular component this GO :0001894 and tissue homeostasis and biological process this GO :0001948 and glycoprotein binding and molecular function this GO :0001968 and fibronectin binding and molecular function this GO :0002020 and protease binding and molecular function this GO :0002042 and cell migration involved in sprouting angiogenesis and biological process this GO :0003779 and actin binding and molecular function this GO :0004872 and receptor activity and molecular function this GO :0005102 and receptor binding and molecular function this GO :0005178 and integrin binding and molecular function this GO :0005515 and protein binding and molecular function this GO :0005518 and collagen binding and molecular function this GO :0005604 and basement membrane and cellular component this GO :0005737 and cytoplasm and cellular component this GO :0005886 and plasma membrane and cellular component this GO :0005911 and cell-cell junction and cellular component this GO :0005912 and adherens junction and cellular component this GO :0005925 and focal adhesion and cellular component this GO :0006874 and cellular calcium ion homeostasis and biological process this GO :0006968 and cellular defense response and biological process this GO :0007155 and cell adhesion and biological process this GO :0007156 and homophilic cell adhesion and biological process this GO :0007159 and leukocyte cell-cell adhesion and biological process this GO :0007160 and cell-matrix adhesion and biological process this GO :0007161 and calcium-independent cell-matrix adhesion and biological process this GO :0007229 and integrin-mediated signaling pathway and biological process this GO :0007275 and multicellular organismal development and biological process this GO :0007411 and axon guidance and biological process this GO :0007596 and blood coagulation and biological process this GO :0008277 and regulation of G-protein coupled receptor protein signaling pathway and biological process this GO :0008284 and positive regulation of cell proliferation and biological process this GO :0008285 and negative regulation of cell proliferation and biological process this GO :0008305 and integrin complex and cellular component this GO :0008354 and germ cell migration and biological process this GO :0009615 and response to virus and biological process this GO :0009897 and external side of plasma membrane and cellular component this GO :0009986 and cell surface and cellular component this GO :0010811 and positive regulation of cell-substrate adhesion and biological process this GO :0010976 and positive regulation of neuron projection development and biological process this GO :0014704 and intercalated disc and cellular component this GO :0014823 and response to activity and biological process this GO :0016020 and membrane and cellular component this GO :0016032 and viral process and biological process this GO :0016477 and cell migration and biological process this GO :0019900 and kinase binding and molecular function this GO :0019901 and protein kinase binding and molecular function this GO :0019904 and protein domain specific binding and molecular function this GO :0021943 and formation of radial glial scaffolds and biological process this GO :0030027 and lamellipodium and cellular component this GO :0030056 and hemidesmosome and cellular component this GO :0030175 and filopodium and cellular component this GO :0030183 and B cell differentiation and biological process this GO :0030198 and extracellular matrix organization and biological process this GO :0030335 and positive regulation of cell migration and biological process this GO :0031175 and neuron projection development and biological process this GO :0031345 and negative regulation of cell projection organization and biological process this GO :0031589 and cell-substrate adhesion and biological process this GO :0031594 and neuromuscular junction and cellular component this GO :0031667 and response to nutrient levels and biological process this GO :0032154 and cleavage furrow and cellular component this GO :0032403 and protein complex binding and molecular function this GO :0032587 and ruffle membrane and cellular component this GO :0032594 and protein transport within lipid bilayer and biological process this GO :0033631 and cell-cell adhesion mediated by integrin and biological process this GO :0034329 and cell junction assembly and biological process this GO :0034667 and integrin alpha3-beta1 complex and cellular component this GO :0034677 and integrin alpha7-beta1 complex and cellular component this GO :0034678 and alpha8-beta1 integrin complex and cellular component this GO :0034679 and alpha9-beta1 integrin complex and cellular component this GO :0034698 and response to this GO nadotropin and biological process this GO :0035748 and myelin sheath abaxonal region and cellular component this GO :0042277 and peptide binding and molecular function this GO :0042383 and sarcolemma and cellular component this GO :0042470 and melanosome and cellular component this GO :0042493 and response to drug and biological process this GO :0043065 and positive regulation of apoptotic process and biological process this GO :0043235 and receptor complex and cellular component this GO :0043236 and laminin binding and molecular function this GO :0043410 and positive regulation of MAPK cascade and biological process this GO :0045087 and innate immune response and biological process this GO :0045121 and membrane raft and cellular component this GO :0045202 and synapse and cellular component this GO :0045214 and sarcomere organization and biological process this GO :0045596 and negative regulation of cell differentiation and biological process this GO :0045665 and negative regulation of neuron differentiation and biological process this GO :0045666 and positive regulation of neuron differentiation and biological process this GO :0045807 and positive regulation of endocytosis and biological process this GO :0046872 and metal ion binding and molecular function this GO :0046982 and protein heterodimerization activity and molecular function this GO :0048675 and axon extension and biological process this GO :0048738 and cardiac muscle tissue development and biological process this GO :0050731 and positive regulation of peptidyl-tyrosine phosphorylation and biological process this GO :0050776 and regulation of immune response and biological process this GO :0050839 and cell adhesion molecule binding and molecular function this GO :0050900 and leukocyte migration and biological process this GO :0051393 and alpha-actinin binding and molecular function this GO :0051726 and regulation of cell cycle and biological process this GO :0055007 and cardiac muscle cell differentiation and biological process this GO :0055037 and recycling endosome and cellular component this GO :0060135 and maternal process involved in female pregnancy and biological process this GO :0070062 and extracellular vesicular exosome and cellular component this GO :0070830 and tight junction assembly and biological process this GO :0071260 and cellular response to mechanical stimulus and biological process this GO :0071305 and cellular response to vitamin D and biological process this GO :0071479 and cellular response to ionizing radiation and biological process this GO :0071559 and response to transforming growth factor beta and biological process this GO :2000811 and negative regulation of anoikis and biological process, this GO :0001618: virus receptor activity, this GO :0001618: virus receptor activity and also this GO :0001948: glycoprotein binding and also this GO :0001968: fibronectin binding and also this GO :0002020: protease binding and also this GO :0003779: actin binding and also this GO :0004872: receptor activity and also this GO :0005102: receptor binding and also this GO :0005178: integrin binding and also this GO :0005515: protein binding and also this GO :0005518: collagen binding and also this GO :0019900: kinase binding and also this GO :0019901: protein kinase binding and also this GO :0019904: protein domain specific binding and also this GO :0032403: protein complex binding and also this GO :0042277: peptide binding and also this GO :0043236: laminin binding and also this GO :0046872: metal ion binding and also this GO :0046982: protein heterodimerization activity and also this GO :0050839: cell adhesion molecule binding and also this GO :0051393: alpha-actinin binding, this GO :0001948: glycoprotein binding, this GO :0001968: fibronectin binding, this GO :0002020: protease binding, this GO :0003779: actin binding, this GO :0004872: receptor activity, this GO :0005102: receptor binding, this GO :0005178: integrin binding, this GO :0005515: protein binding, this GO :0005518: collagen binding, this GO :0019900: kinase binding, this GO :0019901: protein kinase binding, this GO :0019904: protein domain specific binding, this GO :0032403: protein complex binding, this GO :0042277: peptide binding, this GO :0043236: laminin binding, this GO :0046872: metal ion binding, this GO :0046982: protein heterodimerization activity, this GO :0050839: cell adhesion molecule binding, this GO :0051393: alpha-actinin binding, integrin |
| Identity | 6153 |
| Gene | ITGB1 |
| Long gene name | integrin subunit beta 1 |
| Synonyms gene | FNRB MSK12 MDF2 |
| Synonyms gene name | MSK12) , antigen CD29 includes MDF2, beta 1 (fibronectin receptor, beta polypeptide, integrin |
| Synonyms | CD29 GPIIA |
| Locus | 10p11, 22 |
| Discovery year | 1988-06-27 |
| GenBank acession | BC020057 |
| Entrez gene record | 3688 |
| Pubmed identfication | 2524991 |
| RefSeq identity | NM_002211 |
| Classification | Integrin beta subunits CD molecules |
| Havana BLAST/BLAT | OTTHUMG00000017928 |
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