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ITGB2 (534CT6.2.1) Monoclonal Antibody

ITGB2 (534CT6.2.1) Monoclonal Antibody size: 0.1ml 211

Supplier BIOSS PRIMARY UNCONJUGATED ANTIBODIES
Price 211
Size 0.1ml
Contact us Ask Component cell markers and DNA bp. markers are genetic markerser genes or DNA sequenceswith selection audit
Long name1) Monoclonal Antibody, 2, ITGB2 (534CT6
Also known as1) Monoclonal Antibody, 2, ITGB2 (534CT6
CategoryPrimary Antibodies
ConjugationUnconjugated
Target AntigenITGB2
SpecificityThis is a highly specific antibody against ITGB2
Modification(s)None
Modification site(s)Unmodified antibody
ClonalityMonoclonal
Clone number1, 2, 534CT6
SourcePurified His-tagged ITGB2 protein(Fragment) was used to produced this monoclonal antibody
Gene ID number3689
Swiss ProtP05107
Tested Applications IHC-P, WB
Recommended dilutions IHC-P(1:25), WB( 1:1000)
Cross reactivityHuman
Cross reactive species details not every possible cross-reactivity is known, Due to limited amount of testing and knowledge
Background of the target antigen Contributes to natural killer cell cytotoxicity (PubMed:15356110), ICAM2, ICAM3 and ICAM4, Integrin alpha-D/beta-2 is a receptor for ICAM3 and VCAM1, Integrin alpha-L/beta-2 in assosiation with ICAM3, Integrin alpha-M/beta-2 is also a receptor for factor X, Integrin alpha-M/beta-2 recognizes P1 and P2 peptides of fibrinogen gamma chain, Integrin alpha-X/beta-2 recognizes the sequence G-P-R in fibrinogen alpha-chain, Integrins alpha-M/beta-2 and alpha-X/beta-2 are receptors for the iC3b fragment of the third complement component and for fibrinogen, Involved in leukocyte adhesion and transmigration of leukocytes including T-cells and neutrophils (PubMed:11812992), Triggers neutrophil transmigration during lung injury through PTK2B/PYK2-mediated activation (PubMed:18587400), contributes to apoptotic neutrophil phagocytosis by macrophages (PubMed:23775590), Integrin alpha-L/beta-2 is a receptor for ICAM1
Purification method This antibody is purified through a protein G column, followed by dialysis against PBS, 09% (W/V) sodium azide, Purified monoclonal antibody supplied in PBS with 0
Storage conditions 50% glycerol and 0, Store at -20°, 09% sodium azide, C for up to 1 year, Keep the antibody in aqueous buffered solution containing 1% BSA
Synonym names CD18, Cell surface adhesion glycoproteins LFA-1/CR3/p150, Complement receptor C3 subunit beta, ITGB2, Integrin beta-2, LCAMB, LFA-1, MAC-1, MF17, MFI7, 95 subunit beta, LAD
PropertiesC, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by Bioss Primary Unconjugated Antibodies they should be stored frozen at - 24°
About Each murine monoclonal anibody has his own affinity specific for the clone, Mouse monoclonal antibodies are purified protein A or G and can be conjugated to FITC for flow cytometry or FACS and can be of different isotypes, Monoclonals of this antigen are available in different clones
Gene target1) Monoclonal, 2, ITGB2 (534CT6
Short name1) Monoclonal Antibody, 2, ITGB2 (534CT6
Technique Monoclonals or monoclonal antibodies, antibodies against human proteins, antibodies for, Antibody
Alternative name b 2 (complement component 3 receptor 3 and 4 subunit) (534CT6, 1) monoclonal (Antibody to), 2, integrin
Alternative techniqueantibodies
Alternative to gene target CD18 and LAD and LCAMB and LFA-1 and MAC-1 and MF17 and MFI7, Cell surfaces, ITGB2 and IDBG-5590 and ENSG00000160255 and 3689, ITGB2 and IDBG-639611 and ENSBTAG00000017060 and 281877, beta 2 (complement component 3 receptor 3 and 4 subunit), metal ion binding, this GO :0001948 and glycoprotein binding and molecular function this GO :0002224 and toll-like receptor signaling pathway and biological process this GO :0004872 and receptor activity and molecular function this GO :0005515 and protein binding and molecular function this GO :0005886 and plasma membrane and cellular component this GO :0006915 and apoptotic process and biological process this GO :0006954 and inflammatory response and biological process this GO :0007155 and cell adhesion and biological process this GO :0007159 and leukocyte cell-cell adhesion and biological process this GO :0007160 and cell-matrix adhesion and biological process this GO :0007229 and integrin-mediated signaling pathway and biological process this GO :0007267 and cell-cell signaling and biological process this GO :0007275 and multicellular organismal development and biological process this GO :0007596 and blood coagulation and biological process this GO :0008305 and integrin complex and cellular component this GO :0008360 and regulation of cell shape and biological process this GO :0009986 and cell surface and cellular component this GO :0016020 and membrane and cellular component this GO :0019901 and protein kinase binding and molecular function this GO :0030198 and extracellular matrix organization and biological process this GO :0030593 and neutrophil chemotaxis and biological process this GO :0034142 and toll-like receptor 4 signaling pathway and biological process this GO :0043235 and receptor complex and cellular component this GO :0045087 and innate immune response and biological process this GO :0046872 and metal ion binding and molecular function this GO :0050730 and regulation of peptidyl-tyrosine phosphorylation and biological process this GO :0050776 and regulation of immune response and biological process this GO :0050900 and leukocyte migration and biological process this GO :0070062 and extracellular vesicular exosome and cellular component, this GO :0001948: glycoprotein binding, this GO :0001948: glycoprotein binding and also this GO :0004872: receptor activity and also this GO :0005515: protein binding and also this GO :0019901: protein kinase binding and also this GO :0046872: metal ion binding, this GO :0004872: receptor activity, this GO :0005515: protein binding, this GO :0019901: protein kinase binding, this GO :0046872: metal ion binding, integrin
Identity 6155
Gene ITGB2
Long gene name integrin subunit beta 2
Synonyms gene CD18 MFI7
Synonyms gene name beta 2 (antigen CD18 (p95), beta 2 (complement component 3 receptor 3 and 4 subunit) , integrin, lymphocyte function-associated antigen 1, macrophage antigen 1 (mac-1) beta subunit) integrin
Synonyms LFA-1 MAC-1
Synonyms name complement component 3 receptor 3 and 4 subunit
Locus 21q22, 3
Discovery year 1986-01-01
GenBank acession AK222505
Entrez gene record 3689
RefSeq identity NM_000211
Classification Complement system Integrin beta subunits CD molecules
Havana BLAST/BLAT OTTHUMG00000090257
Locus Specific Databases ITGB2base: Mutation registry for Leukocyte adhesion deficiency I (LAD-I) LRG_76

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