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Jak3 Antibody

Jak3 Antibody size: 0.1ml 263

Supplier BIOSS PRIMARY UNCONJUGATED ANTIBODIES
Price 263
Size 0.1ml
Contact us Ask Component cell markers and DNA bp. markers are genetic markerser genes or DNA sequenceswith selection audit
Long nameJak3 Primary Polyclonal Antibody
Also known asJak3 PAb
CategoryPrimary Antibodies
ConjugationUnconjugated
Target AntigenJak3
Specificity This has 85% sequence similarity with JAK1 and may cross-react, This is a highly specific antibody against Jak3
Modification(s)None
Modification site(s)Unmodified antibody
ClonalityPolyclonal antibody
Clone numberPolyclonal antibody
Concentration1ug per 1ul
Immunogen range610-660/1124
Subcellular locationCytoplasm
SourceThis antibody was obtained by immunization of the host with KLH conjugated synthetic peptide derived from human Jak3
Gene ID number3718
Swiss ProtP52333
Tested Applications IF(IHC-P), IHC-P, WB
Recommended dilutions IF(IHC-P)(1:50-200), IHC-P(1:100-500), WB(1:100-1000)
Cross reactivity Mouse, Rat, Human
Cross reactive species details not every possible cross-reactivity is known, Due to limited amount of testing and knowledge
Background of the target antigen Following ligand binding to cell surface receptors, For example, IL15R and IL21R, IL4R, IL7R, IL9R, In the cytoplasm, JAK1 and JAK3 molecules bind to IL2R beta (IL2RB) and gamma chain (IL2RG) subunits inducing the tyrosine phosphorylation of both receptor subunits on their cytoplasmic domain, Mediates essential signaling events in both innate and adaptive immunity and plays a crucial role in hematopoiesis during T-cells development, Once activated, Phosphorylated STATs then form homodimer or heterodimers and translocate to the nucleus to activate gene transcription, STAT5A AND STAT5B are recruited, Subsequently, Then, creating docking sites for STATs proteins, development, dimerized STAT5 translocates to the nucleus and promotes the transcription of specific target genes in a cytokine-specific fashion, or differentiation, phosphorylated and activated by JAK1 and JAK3, phosphorylates specific tyrosine residues on the cytoplasmic tails of the receptor, phosphorylates the STATs proteins once they are recruited to the receptor, plays a pivotal role in signal transduction via its association with type I receptors sharing the common subunit gamma such as IL2R, upon IL2R activation by IL2, Non-receptor tyrosine kinase involved in various processes such as cell growth
Purification methodThis antibody was purified via Protein A
Storage conditions 50% glycerol and 0, Store at -20°, 09% sodium azide, C for up to 1 year, Keep the antibody in aqueous buffered solution containing 1% BSA
Synonym names JAK-3, JAK3, JAK3_HUMAN, Janus kinase 3, L-JAK, LJAK, Leukocyte janus kinase, Tyrosine-protein kinase JAK3, JAKL
PropertiesC, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by Bioss Primary Unconjugated Antibodies they should be stored frozen at - 24°
Gene targetJak3
Short nameJak3 Antibody
Technique antibodies against human proteins, antibodies for, Antibody
Alternative nameJanus kinase 3 (Antibody to)
Alternative techniqueantibodies
Identity 6193
Gene JAK3
Long gene name Janus kinase 3
Synonyms L-JAK JAKL LJAK JAK3_HUMAN JAK-3
Synonyms name tyrosine-protein kinase JAK3 leukocyte Janus kinase
Locus 19p13, 11
Discovery year 1994-12-19
GenBank acession U31601
Entrez gene record 3718
Pubmed identfication 8921370 9226382
RefSeq identity NM_000215
Havana BLAST/BLAT OTTHUMG00000165648
Locus Specific Databases JAK3base: Mutation registry for autosomal recessive severe combined JAK3 deficiency LRG_77

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