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Jak3 Antibody, Biotin Conjugated

Jak3 Antibody, Biotin Conjugated size: 0.1ml 333

Supplier BIOSS PRIMARY CONJUGATED ANTIBODIES 1
Price 333
Size 0.1ml
Contact us Ask Component cell markers and DNA bp. markers are genetic markerser genes or DNA sequenceswith selection audit
Long name Biotin Conjugated, Jak3 Polyclonal Antibody
CategoryConjugated Primary Antibodies
ConjugationBiotinylated
Host OrganismRabbit (Oryctolagus cuniculus)
Target AntigenJak3
Specificity This has 85% sequence similarity with JAK1 and may cross-react, This is a highly specific antibody against Jak3
ModificationUnmodified
Modification siteNone
ClonalityPolyclonal
ClonePolyclonal antibody
Concentration1ug per 1ul
Immunogen_range610-660/1124
Subcellular locationCytoplasm
SourceKLH conjugated synthetic peptide derived from human Jak3
Gene ID number3718
Swiss ProtP52333
Tested applications IHC-P, WB
Recommended dilutions IHC-P(1:100-500), WB(1:100-1000)
Crossreactivity Mouse, Rat, Human
Crossreactive species details not every possible cross-reactivity is known, Due to limited amount of testing and knowledge
Antigen background Following ligand binding to cell surface receptors, For example, IL15R and IL21R, IL4R, IL7R, IL9R, In the cytoplasm, JAK1 and JAK3 molecules bind to IL2R beta (IL2RB) and gamma chain (IL2RG) subunits inducing the tyrosine phosphorylation of both receptor subunits on their cytoplasmic domain, Mediates essential signaling events in both innate and adaptive immunity and plays a crucial role in hematopoiesis during T-cells development, Once activated, Phosphorylated STATs then form homodimer or heterodimers and translocate to the nucleus to activate gene transcription, STAT5A AND STAT5B are recruited, Subsequently, Then, creating docking sites for STATs proteins, development, dimerized STAT5 translocates to the nucleus and promotes the transcription of specific target genes in a cytokine-specific fashion, or differentiation, phosphorylated and activated by JAK1 and JAK3, phosphorylates specific tyrosine residues on the cytoplasmic tails of the receptor, phosphorylates the STATs proteins once they are recruited to the receptor, plays a pivotal role in signal transduction via its association with type I receptors sharing the common subunit gamma such as IL2R, upon IL2R activation by IL2, Non-receptor tyrosine kinase involved in various processes such as cell growth
Purification methodThis antibody was purified via Protein A
Storage conditions 50% glycerol and 0, Store refrigerated at 2 to 8 degrees Celcius for up to 1 year, 09% sodium azide, Keep the antibody in an aqueous buffered solution containing 1% BSA
Excitation EmissionN/A
Synonyms JAK-3, JAK3, JAK3_HUMAN, Janus kinase 3, L-JAK, LJAK, Leukocyte janus kinase, Tyrosine-protein kinase JAK3, JAKL
Properties Avidin and Streptavidin bind to the small biotin and are couple to HRP or AP for ELISA, Biotin conjugates can be detected by horseradish peroxidase, To break the streptavidin Biotin bond we suggest to use a 6 molar guanidine HCl solution with acidity of pH 1, alkaline phosphatase substrates or anti biotin conjugated antibodies, 6, C, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by Bioss Primary Conjugated Antibodies they should be stored frozen at - 24°
Gene targetJak3 Conjugated
Short name Conjugated, Jak3 Antibody
Technique antibodies against human proteins, antibodies for, antibody Conjugates, Antibody
LabelBiotin
Alternative name biotinilated coupled, Janus kinase 3 (Antibody to)
Alternative techniqueantibodies

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