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Jak3 (Tyr980 + Tyr981) Antibody

Jak3 (Tyr980 + Tyr981) Antibody size: 0.1ml 281

Supplier BIOSS PRIMARY UNCONJUGATED ANTIBODIES
Price 281
Size 0.1ml
Contact us Ask Component cell markers and DNA bp. markers are genetic markerser genes or DNA sequenceswith selection audit
Long nameJak3 (Tyr980 + Tyr981) Antibody
Also known asJak3 (Tyr980 + Tyr981) Antibody
CategoryPrimary Antibodies
ConjugationUnconjugated
Target AntigenJak3 Tyr980 + Tyr981
Specificity These phosphorylation sites are homologous to Tyr976 + Tyr977 in Mouse and Rat, This is a highly specific antibody against Jak3 Tyr980 + Tyr981
Modification(s)Phosphorylation
Modification site(s)Tyr980 + Tyr981
ClonalityPolyclonal antibody
Clone numberPolyclonal antibody
Concentration1ug per 1ul
Immunogen range971-990/1124
Subcellular location Cell membrane, Cytoplasm
SourceKLH conjugated synthetic phosphopeptide derived from human Jak3 around the phosphorylation site of Tyr980/981
Gene ID number3718
Swiss ProtP52333
Tested Applications IF(IHC-P), IHC-P, WB
Recommended dilutions IF(IHC-P)(1:50-200), IHC-P(1:100-500), WB(1:100-1000)
Cross reactivity Mouse, Rat, Human
Cross reactive species details not every possible cross-reactivity is known, Due to limited amount of testing and knowledge
Background of the target antigen Following ligand binding to cell surface receptors, For example, IL15R and IL21R, IL4R, IL7R, IL9R, In the cytoplasm, JAK1 and JAK3 molecules bind to IL2R beta (IL2RB) and gamma chain (IL2RG) subunits inducing the tyrosine phosphorylation of both receptor subunits on their cytoplasmic domain, Mediates essential signaling events in both innate and adaptive immunity and plays a crucial role in hematopoiesis during T-cells development, Once activated, Phosphorylated STATs then form homodimer or heterodimers and translocate to the nucleus to activate gene transcription, STAT5A AND STAT5B are recruited, Subsequently, Then, creating docking sites for STATs proteins, development, dimerized STAT5 translocates to the nucleus and promotes the transcription of specific target genes in a cytokine-specific fashion, or differentiation, phosphorylated and activated by JAK1 and JAK3, phosphorylates specific tyrosine residues on the cytoplasmic tails of the receptor, phosphorylates the STATs proteins once they are recruited to the receptor, plays a pivotal role in signal transduction via its association with type I receptors sharing the common subunit gamma such as IL2R, upon IL2R activation by IL2, Non-receptor tyrosine kinase involved in various processes such as cell growth
Purification methodThis antibody was purified via Protein A
Storage conditions 50% glycerol and 0, Store at -20°, 09% sodium azide, C for up to 1 year, Keep the antibody in aqueous buffered solution containing 1% BSA
Synonym names JAK-3, JAK3, JAK3_HUMAN, Janus kinase 3, L-JAK, LJAK, Leukocyte janus kinase, Tyrosine-protein kinase JAK3, JAKL
PropertiesC, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by Bioss Primary Unconjugated Antibodies they should be stored frozen at - 24°
Gene targetJak3 (Tyr980 + Tyr981)
Short nameJak3 (Tyr980 + Tyr981) Antibody
Technique antibodies against human proteins, antibodies for, Antibody
Alternative nameJanus kinase 3 (Tyr980 and Tyr981) (Antibody to)
Alternative techniqueantibodies

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