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JIP2 Antibody, Biotin Conjugated

JIP2 Antibody, Biotin Conjugated size: 0.1ml 333

Supplier BIOSS PRIMARY CONJUGATED ANTIBODIES 1
Price 333
Size 0.1ml
Contact us Ask Component cell markers and DNA bp. markers are genetic markerser genes or DNA sequenceswith selection audit
Long name Biotin Conjugated, JIP2 Polyclonal Antibody
CategoryConjugated Primary Antibodies
ConjugationBiotinylated
Host OrganismRabbit (Oryctolagus cuniculus)
Target AntigenJIP2
SpecificityThis is a highly specific antibody against JIP2
ModificationUnmodified
Modification siteNone
ClonalityPolyclonal
ClonePolyclonal antibody
Concentration1ug per 1ul
SourceKLH conjugated synthetic peptide derived from human JIP2
Tested applications IHC-P, WB
Recommended dilutions IHC-P(1:100-500), WB(1:100-1000)
Crossreactivity Mouse, Rat, Human
Crossreactive species details not every possible cross-reactivity is known, Due to limited amount of testing and knowledge
Antigen background ATF-2 and c-Jun also contain the JNK binding domain and are thought to compete with JIP-1 for JNK binding (6), Evidence suggests that JNK1 and JNK2 bind to JIP-1 with greater affinity than to ATF-2 and c-Jun, JIP-1 (for JNK interacting protein-1) has been identified as a cytoplasmic inhibitor of JNK that retains JNK in the cytoplasm, JIP-1 contains an amino terminal JNK binding domain and a carboxy terminal SH3 domain, JIP-1c (also designated islet-brain 1 or IB-1), JIP-2a, JIP-2b and JIP-3, JNK1 is activated by dual phosphorylation at a Thr-Pro-Tyr motif in response to ultraviolet (UV) light, Multiple splice variants if JIP-1, Ser-63 and Ser-73, Two additional JNK family members have been identified as JNK2 and JNK3 (3), and it functions to phosphorylate c-Jun at amino terminal serine regulatory sites, have been identified in brain (7), including JIP-1b, resulting in transcriptional activation (2-5), thereby inhibiting JNK-regulated gene expression, which are targets of the JNK signaling pathway, c-Jun NH2-terminal kinases (JNKs) are distant members of the MAP kinase family (1)
Purification methodThis antibody was purified via Protein A
Storage conditions 50% glycerol and 0, Store refrigerated at 2 to 8 degrees Celcius for up to 1 year, 09% sodium azide, Keep the antibody in an aqueous buffered solution containing 1% BSA
Excitation EmissionN/A
Synonyms IB2 JIP2
Properties Avidin and Streptavidin bind to the small biotin and are couple to HRP or AP for ELISA, Biotin conjugates can be detected by horseradish peroxidase, To break the streptavidin Biotin bond we suggest to use a 6 molar guanidine HCl solution with acidity of pH 1, alkaline phosphatase substrates or anti biotin conjugated antibodies, 6, C, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by Bioss Primary Conjugated Antibodies they should be stored frozen at - 24°
Gene targetJIP2 Conjugated
Short name Conjugated, JIP2 Antibody
Technique antibodies against human proteins, antibodies for, antibody Conjugates, Antibody
LabelBiotin
Alternative name biotinilated coupled, JIP2 (Antibody to)
Alternative techniqueantibodies
Identity 6883
Gene MAPK8IP2
Long gene name mitogen-activated protein kinase 8 interacting protein 2
Synonyms gene PRKM8IPL
Synonyms gene name PRKM8 interacting protein-like
Synonyms name islet-brain 2 JNK-interacting protein 2
Locus 22q13, 33
Discovery year 1999-10-12
GenBank acession AL021708
Entrez gene record 23542
Pubmed identfication 10490659
RefSeq identity NM_012324
Havana BLAST/BLAT OTTHUMG00000150181

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