JNK1/2 Antibody

JNK1/2 Antibody size: 0.1ml 263

Supplier BIOSS PRIMARY UNCONJUGATED ANTIBODIES

Price 263

Size 0.1ml

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Long name	JNK1/2 Primary Polyclonal Antibody
Also known as	JNK1/2 PAb
Category	Primary Antibodies
Conjugation	Unconjugated
Target Antigen	JNK1/2
Specificity	There is a 71% chance that this antibody will cross-react with MAPK10(JNK3) if in the same tissue, This is a highly specific antibody against JNK1/2
Modification(s)	None
Modification site(s)	Unmodified antibody
Clonality	Polyclonal antibody
Clone number	Polyclonal antibody
Concentration	1ug per 1ul
Immunogen range	340-390/424
Subcellular location	Nucleus, Cytoplasm
Source	This antibody was obtained by immunization of the host with KLH conjugated synthetic peptide derived from human JNK2
Gene ID number	5601
Swiss Prot	P45984
Tested Applications	IF(IHC-P), IHC-P, WB
Recommended dilutions	IF(IHC-P)(1:50-200), IHC-P(1:100-500), WB(1:100-1000)
Cross reactivity	Mouse, Rat, Human
Cross reactive species details	not every possible cross-reactivity is known, Due to limited amount of testing and knowledge
Background of the target antigen	BCL10, Extracellular stimuli such as proinflammatory cytokines or physical stress stimulate the stress-activated protein kinase/c-Jun N-terminal kinase (SAP/JNK) signaling pathway, However, In T-cells, In response to oxidative or ribotoxic stresses, In this cascade, In turn, JUNB is not a substrate for JNK2 alpha-2, MAP2K7 and MAP3K7/TAK1 to regulate JUN protein levels, MAPK8 and MAPK9 are required for polarized differentiation of T-helper cells into Th1 cells, MAPK9 isoforms display different binding patterns: alpha-1 and alpha-2 preferentially bind to JUN, MAPK9/JNK2 phosphorylates a number of transcription factors, Participates also in neurite growth in spiral ganglion neurons, Plays an important role in the osmotic stress-induced epithelial tight-junctions disruption, Promotes stressed cell apoptosis by phosphorylating key regulatory factors including TP53 and YAP1, Upon T-cell receptor (TCR) stimulation, When activated, and JUND binds only weakly to it, differentiation, inhibits rRNA synthesis by phosphorylating and inactivating the RNA polymerase 1-specific transcription initiation factor RRN3, is activated by CARMA1, migration, primarily components of AP-1 such as JUN and ATF2 and thus regulates AP-1 transcriptional activity, promotes beta-catenin/CTNNB1 degradation and inhibits the canonical Wnt signaling pathway, there is no correlation between binding and phosphorylation, transformation and programmed cell death, two dual specificity kinases MAP2K4/MKK4 and MAP2K7/MKK7 phosphorylate and activate MAPK9/JNK2, whereas beta-1 and beta-2 bind to ATF2, which is achieved at about the same efficiency by all isoforms, Serine/threonine-protein kinase involved in various processes such as cell proliferation
Purification method	This antibody was purified via Protein A
Storage conditions	50% glycerol and 0, Store at -20°, 09% sodium azide, C for up to 1 year, Keep the antibody in aqueous buffered solution containing 1% BSA
Synonym names	JNK-55, JNK2A, JNK2ALPHA, JNK2B, JNK2BETA, MAP kinase 9, MAPK 9, MAPK9, Mitogen-activated protein kinase 9, PRKM9, SAPK, SAPK1a, Stress-activated protein kinase 1a, Stress-activated protein kinase JNK2, c-Jun N-terminal kinase 2, p54a, p54aSAPK, JNK2
Properties	C, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by Bioss Primary Unconjugated Antibodies they should be stored frozen at - 24°
Gene target	JNK1/2
Short name	JNK1/2 Antibody
Technique	antibodies against human proteins, antibodies for, Antibody
Alternative name	JNK1/2 (Antibody to)
Alternative technique	antibodies
Identity	6881
Gene	MAPK8
Long gene name	mitogen-activated protein kinase 8
Synonyms gene	PRKM8
Synonyms	JNK JNK1 SAPK1
Synonyms name	JUN N-terminal kinase
Locus	10q11, 22
Discovery year	1998-04-28
GenBank acession	L26318
Entrez gene record	5599
Pubmed identfication	8137421 8654373
Classification	Mitogen-activated protein kinases
Havana BLAST/BLAT	OTTHUMG00000018172

JNK1/2 Antibody

JNK1/2 Antibody size: 0.1ml 263

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