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JNK1 Antibody

JNK1 Antibody size: 0.1ml 354

Supplier BIOSS PRIMARY UNCONJUGATED ANTIBODIES
Price 354
Size 0.1ml
Contact us Ask Component cell markers and DNA bp. markers are genetic markerser genes or DNA sequenceswith selection audit
Long nameJNK1 Primary Polyclonal Antibody
Also known asJNK1 PAb
CategoryPrimary Antibodies
ConjugationUnconjugated
Target AntigenJNK1
SpecificityThis is a highly specific antibody against JNK1
Modification(s)None
Modification site(s)Unmodified antibody
ClonalityPolyclonal antibody
Clone numberPolyclonal antibody
SourceSynthetic peptide
Gene ID number5599
Swiss ProtP45983
Tested ApplicationsWB
Recommended dilutions000), 000~2, WB (1:1
Cross reactivity Mouse, Rat, Human
Cross reactive species details not every possible cross-reactivity is known, Due to limited amount of testing and knowledge
Background of the target antigen BCL2 dissociation from BECN1, Contributes to the survival of erythroid cells by phosphorylating the antagonist of cell death BAD upon EPO stimulation, ELK1, Extracellular stimuli such as proinflammatory cytokines or physical stress stimulate the stress-activated protein kinase/c-Jun N-terminal kinase (SAP/JNK) signaling pathway, In T-cells, In the developing brain, In this cascade, In turn, JDP2 and ATF2 and thus regulates AP-1 transcriptional activity, Loss of this interaction abrogates the acetylation required for replication initiation, MAPK8 and MAPK9 are required for polarized differentiation of T-helper cells into Th1 cells, MAPK8/JNK1 phosphorylates a number of transcription factors, Mediates starvation-induced BCL2 phosphorylation, Phosphorylates STMN2 and hence regulates microtubule dynamics, Phosphorylates several other substrates including heat shock factor protein 4 (HSF4), Phosphorylates the CLOCK-ARNTL/BMAL1 heterodimer and plays a role in the regulation of the circadian clock (PubMed:22441692), Phosphorylates the replication licensing factor CDT1, Promotes stressed cell apoptosis by phosphorylating key regulatory factors including p53/TP53 and Yes-associates protein YAP1, and thus activation of autophagy, controlling neurite elongation in cortical neurons, differentiation, inhibiting the interaction between CDT1 and the histone H4 acetylase HBO1 to replication origins, migration, negatively regulates the rate of exit from multipolar stage and of radial migration from the ventricular zone, or the E3 ligase ITCH, primarily components of AP-1 such as JUN, the deacetylase SIRT1, through its cytoplasmic activity on STMN2, transformation and programmed cell death, two dual specificity kinases MAP2K4/MKK4 and MAP2K7/MKK7 phosphorylate and activate MAPK8/JNK1, Serine/threonine-protein kinase involved in various processes such as cell proliferation
Storage conditions 50% glycerol and 0, Store at -20°, 09% sodium azide, C for up to 1 year, Keep the antibody in aqueous buffered solution containing 1% BSA
Synonym names JNK-46, JNK1, JNK1A2, JNK21B1/2, MAP kinase 8, MAPK 8, MAPK8, Mitogen-activated protein kinase 8, PRKM8, SAPK1, SAPK1c, Stress-activated protein kinase 1c, Stress-activated protein kinase JNK1, c-Jun N-terminal kinase 1, JNK
PropertiesC, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by Bioss Primary Unconjugated Antibodies they should be stored frozen at - 24°
Gene targetJNK1
Short nameJNK1 Antibody
Technique antibodies against human proteins, antibodies for, Antibody
Alternative nameJNK1 (Antibody to)
Alternative techniqueantibodies
Identity 6881
Gene MAPK8
Long gene name mitogen-activated protein kinase 8
Synonyms gene PRKM8
Synonyms JNK JNK1 SAPK1
Synonyms name JUN N-terminal kinase
Locus 10q11, 22
Discovery year 1998-04-28
GenBank acession L26318
Entrez gene record 5599
Pubmed identfication 8137421 8654373
Classification Mitogen-activated protein kinases
Havana BLAST/BLAT OTTHUMG00000018172

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