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KDM1A Antibody, Cy7 Conjugated

KDM1A Antibody, Cy7 Conjugated size: 0.1ml 350

Supplier BIOSS PRIMARY CONJUGATED ANTIBODIES 1
Price 350
Size 0.1ml
Contact us Ask Component cell markers and DNA bp. markers are genetic markerser genes or DNA sequenceswith selection audit
Long name Cy7 Conjugated, KDM1A Polyclonal Antibody
CategoryConjugated Primary Antibodies
ConjugationCy7
Host OrganismRabbit (Oryctolagus cuniculus)
Target AntigenKDM1A
SpecificityThis is a highly specific antibody against KDM1A
ModificationUnmodified
Modification siteNone
ClonalityPolyclonal
ClonePolyclonal antibody
Concentration1ug per 1ul
Immunogen_range120-170/852
Subcellular locationNucleus
SourceKLH conjugated synthetic peptide derived from human KDM1A
Gene ID number23028
Swiss ProtO60341
Tested applicationsIF(IHC-P)
Recommended dilutionsIF(IHC-P)(1:50-200)
Crossreactivity Mouse, Rat, Human
Crossreactive species details not every possible cross-reactivity is known, Due to limited amount of testing and knowledge
Antigen background Acts as a corepressor by mediating demethylation of H3K4me, Acts by oxidizing the substrate by FAD to generate the corresponding imine that is subsequently hydrolyzed, Alone, Also acts as a coactivator of androgen receptor (ANDR)-dependent transcription, CDN7 and KRT8, Component of a RCOR/GFI/KDM1A/HDAC complex that suppresses, Demethylates and stabilizes the DNA methylase DNMT1, Demethylates both mono- (H3K4me1) and di-methylated (H3K4me2) H3K4me, Demethylates di-methylated 'Lys-370' of p53/TP53 which prevents interaction of p53/TP53 with TP53BP1 and represses p53/TP53-mediated transcriptional activation, Effector of SNAI1-mediated transcription repression of E-cadherin/CDH1, May play a role in the repression of neuronal genes, Required for gastrulation during embryogenesis, Required for the maintenance of the silenced state of the SNAI1 target genes E-cadherin/CDH1 and CDN7, The presence of PRKCB in ANDR-containing complexes, a number of genes implicated in multilineage blood cell development, a specific tag for epigenetic transcriptional activation, a specific tag for epigenetic transcriptional repression, a specific tag that prevents demethylation H3K4me, by being recruited to ANDR target genes and mediating demethylation of H3K9me, depending on the context, it is unable to demethylate H3K4me on nucleosomes and requires the presence of RCOR1/CoREST to achieve such activity, prevents H3K4me demethylase activity of KDM1A, thereby acting as a coactivator or a corepressor, via histone deacetylase (HDAC) recruitment, which mediates phosphorylation of 'Thr-6' of histone H3 (H3T6ph), Histone demethylase that demethylates both 'Lys-4' (H3K4me) and 'Lys-9' (H3K9me) of histone H3
Purification methodThis antibody was purified via Protein A
Storage conditions 50% glycerol and 0, Store refrigerated at 2 to 8 degrees Celcius for up to 1 year, 09% sodium azide, Keep the antibody in an aqueous buffered solution containing 1% BSA
Excitation Emission743nm/767nm
Synonyms KIAA0601 BHC110 LSD1
PropertiesC, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by Bioss Primary Conjugated Antibodies they should be stored frozen at - 24°
ConjugatedThese antibodies are excite for emission at 650 nm and detected at a 676 nm wavelengths
Gene targetKDM1A Conjugated
Short name Conjugated, KDM1A Antibody
Technique antibodies against human proteins, antibodies for, antibody Conjugates, Antibody
LabelCy7
Alternative name cyanine 7 coupled, KDM1A (Antibody to)
Alternative techniqueantibodies
Identity 29079
Gene KDM1A
Long gene name lysine demethylase 1A
Synonyms gene AOF2 KDM1
Synonyms gene name amine oxidase (flavin containing) domain 2 lysine (K)-specific demethylase 1
Locus 1p36, 12
Discovery year 2004-02-26
GenBank acession AL031428
Entrez gene record 23028
Pubmed identfication 9628581 12493763
RefSeq identity NM_015013
Classification Lysine demethylases
Havana BLAST/BLAT OTTHUMG00000003220

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