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KMT1E/SETDB1 Antibody

KMT1E/SETDB1 Antibody size: 0.1ml 263

Supplier BIOSS PRIMARY UNCONJUGATED ANTIBODIES
Price 263
Size 0.1ml
Contact us Ask Component cell markers and DNA bp. markers are genetic markerser genes or DNA sequenceswith selection audit
Long nameKMT1E/SETDB1 Primary Polyclonal Antibody
Also known asKMT1E/SETDB1 PAb
CategoryPrimary Antibodies
ConjugationUnconjugated
Target AntigenKMT1E/SETDB1
SpecificityThis is a highly specific antibody against KMT1E/SETDB1
Modification(s)None
Modification site(s)Unmodified antibody
ClonalityPolyclonal antibody
Clone numberPolyclonal antibody
Concentration1ug per 1ul
Immunogen range210-260/1291
Subcellular locationNucleus
SourceThis antibody was obtained by immunization of the host with KLH conjugated synthetic peptide derived from human SETDB1
Gene ID number9869
Swiss ProtQ15047
Tested Applications IF(IHC-P), IHC-P, WB
Recommended dilutions IF(IHC-P)(1:50-200), IHC-P(1:100-500), WB(1:100-1000)
Cross reactivity Mouse, Rat, Human
Cross reactive species details not every possible cross-reactivity is known, Due to limited amount of testing and knowledge
Background of the target antigen Also required to maintain a transcriptionally repressive state of genes in undifferentiated embryonic stem cells (ESCs) (PubMed:24623306), Associates at promoter regions of tumor suppressor genes (TSGs) leading to their gene silencing (PubMed:24623306), CBX3 and/or CBX5) proteins to methylated histones, H3 'Lys-9' trimethylation is coordinated with DNA methylation, H3 'Lys-9' trimethylation represents a specific tag for epigenetic transcriptional repression by recruiting HP1 (CBX1, Its activity is dependent on MBD1 and is heritably maintained through DNA replication by being recruited by CAF-1, Mainly functions in euchromatin regions, Probably forms a complex with MBD1 and ATF7IP that represses transcription and couples DNA methylation and histone 'Lys-9' trimethylation, Probably forms a corepressor complex required for activated KRAS-mediated promoter hypermethylation and transcriptional silencing of tumor suppressor genes (TSGs) or other tumor-related genes in colorectal cancer (CRC) cells (PubMed:24623306), SETDB1 is targeted to histone H3 by TRIM28/TIF1B, The SETDB1-TRIM28-ZNF274 complex may play a role in recruiting ATRX to the 3'-exons of zinc-finger coding genes with atypical chromatin signatures to establish or maintain/protect H3K9me3 at these transcriptionally active regions (PubMed:27029610), a factor recruited by KRAB zinc-finger proteins, thereby playing a central role in the silencing of euchromatic genes, Histone methyltransferase that specifically trimethylates 'Lys-9' of histone H3
Purification methodThis antibody was purified via Protein A
Storage conditions 50% glycerol and 0, Store at -20°, 09% sodium azide, C for up to 1 year, Keep the antibody in aqueous buffered solution containing 1% BSA
Synonym names ERG-associated protein with SET domain, H3-K9-HMTase 4, H3-K9-HMTase4, Histone H3-K9 methyltransferase 4, Histone-lysine N-methyltransferase SETDB1, KG1T, KIAA0067, KMT1E, Lysine N-methyltransferase 1E, SET domain bifurcated 1, SETDB1, TDRD21, ESET
PropertiesC, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by Bioss Primary Unconjugated Antibodies they should be stored frozen at - 24°
Gene targetKMT1E/SETDB1
Short nameKMT1E/SETDB1 Antibody
Technique antibodies against human proteins, antibodies for, Antibody
Alternative nameKMT1E/SETDB1 (Antibody to)
Alternative techniqueantibodies
Identity 10761
Gene SETDB1
Long gene name SET domain bifurcated 1
Synonyms gene name SET domain, bifurcated 1
Synonyms KG1T KIAA0067 ESET KMT1E TDRD21
Synonyms name tudor domain containing 21
Locus 1q21, 3
Discovery year 1999-07-19
GenBank acession D31891
Entrez gene record 9869
Pubmed identfication 10343109
RefSeq identity NM_001145415
Classification Methyl-CpG binding domain containing Lysine methyltransferases Tudor domain containing
Havana BLAST/BLAT OTTHUMG00000035003

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