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KMT1E/SETDB1 Antibody, Cy3 Conjugated

KMT1E/SETDB1 Antibody, Cy3 Conjugated size: 0.1ml 350

Supplier BIOSS PRIMARY CONJUGATED ANTIBODIES 1
Price 350
Size 0.1ml
Contact us Ask Component cell markers and DNA bp. markers are genetic markerser genes or DNA sequenceswith selection audit
Long name Cy3 Conjugated, KMT1E/SETDB1 Polyclonal Antibody
CategoryConjugated Primary Antibodies
Conjugationcy3 conjugation kit
Host OrganismRabbit (Oryctolagus cuniculus)
Target AntigenKMT1E/SETDB1
SpecificityThis is a highly specific antibody against KMT1E/SETDB1
ModificationUnmodified
Modification siteNone
ClonalityPolyclonal
ClonePolyclonal antibody
Concentration1ug per 1ul
Immunogen_range210-260/1291
Subcellular locationNucleus
SourceKLH conjugated synthetic peptide derived from human SETDB1
Gene ID number9869
Swiss ProtQ15047
Tested applicationsIF(IHC-P)
Recommended dilutionsIF(IHC-P)(1:50-200)
Crossreactivity Mouse, Rat, Human
Crossreactive species details not every possible cross-reactivity is known, Due to limited amount of testing and knowledge
Antigen background Also required to maintain a transcriptionally repressive state of genes in undifferentiated embryonic stem cells (ESCs) (PubMed:24623306), Associates at promoter regions of tumor suppressor genes (TSGs) leading to their gene silencing (PubMed:24623306), CBX3 and/or CBX5) proteins to methylated histones, H3 'Lys-9' trimethylation is coordinated with DNA methylation, H3 'Lys-9' trimethylation represents a specific tag for epigenetic transcriptional repression by recruiting HP1 (CBX1, Its activity is dependent on MBD1 and is heritably maintained through DNA replication by being recruited by CAF-1, Mainly functions in euchromatin regions, Probably forms a complex with MBD1 and ATF7IP that represses transcription and couples DNA methylation and histone 'Lys-9' trimethylation, Probably forms a corepressor complex required for activated KRAS-mediated promoter hypermethylation and transcriptional silencing of tumor suppressor genes (TSGs) or other tumor-related genes in colorectal cancer (CRC) cells (PubMed:24623306), SETDB1 is targeted to histone H3 by TRIM28/TIF1B, The SETDB1-TRIM28-ZNF274 complex may play a role in recruiting ATRX to the 3'-exons of zinc-finger coding genes with atypical chromatin signatures to establish or maintain/protect H3K9me3 at these transcriptionally active regions (PubMed:27029610), a factor recruited by KRAB zinc-finger proteins, thereby playing a central role in the silencing of euchromatic genes, Histone methyltransferase that specifically trimethylates 'Lys-9' of histone H3
Purification methodThis antibody was purified via Protein A
Storage conditions 50% glycerol and 0, Store refrigerated at 2 to 8 degrees Celcius for up to 1 year, 09% sodium azide, Keep the antibody in an aqueous buffered solution containing 1% BSA
Excitation Emission512, 550nm/570, 615nm
Synonyms KG1T KIAA0067 ESET KMT1E TDRD21
Properties 1 of the KMT1E/SETDB1 Antibody, Conjugated can be used in flow cytometry but typically shows lower fluorescence intensity comparable to that of PE or APC, Cy3 antibodies are excited by the 488-nanometer wave of an argon laser and the 633-nanometer line of a helium-neon diode laser, This Bioss Primary Conjugated Antibodies antibody is well suited for fluorescent microscopy, C, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by Bioss Primary Conjugated Antibodies they should be stored frozen at - 24°
Gene targetKMT1E/SETDB1 Conjugated
Short name Conjugated, KMT1E/SETDB1 Antibody
Technique antibodies against human proteins, antibodies for, antibody Conjugates, Antibody
LabelCy3
Alternative name cyanine 3 coupled, KMT1E/SETDB1 (Antibody to)
Alternative techniqueantibodies
Identity 10761
Gene SETDB1
Long gene name SET domain bifurcated 1
Synonyms gene name SET domain, bifurcated 1
Synonyms name tudor domain containing 21
Locus 1q21, 3
Discovery year 1999-07-19
GenBank acession D31891
Entrez gene record 9869
Pubmed identfication 10343109
RefSeq identity NM_001145415
Classification Methyl-CpG binding domain containing Lysine methyltransferases Tudor domain containing
Havana BLAST/BLAT OTTHUMG00000035003

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