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KRIT1 Antibody, ALEXA FLUOR 488

KRIT1 Antibody, ALEXA FLUOR 488 size: 100ul 332

Supplier BIOSS PRIMARY CONJUGATED ANTIBODIES
Price 332
Size 100ul
Contact us Ask Component cell markers and DNA bp. markers are genetic markerser genes or DNA sequenceswith selection audit
Long name ALEXA FLUOR 488 Conjugated, KRIT1 Polyclonal Antibody
Also known asAnti-KRIT1 PAb ALEXA FLUOR 488
CategoryConjugated Primary Antibodies
Conjugated with 488, ALEXA FLUOR®
Host OrganismRabbit (Oryctolagus cuniculus)
Target AntigenKRIT1
SpecificityThis is a highly specific antibody against KRIT1
ModificationUnmodified
Modification SiteNone
ClonalityPolyclonal
ClonePolyclonal antibody
Concentration1ug per 1ul
Immunogen range650-700/736
Subcellular locationCell membrane
SourceThis antibody was obtained by immunization of the host with KLH conjugated synthetic peptide derived from human KRIT1
Gene ID Number889
Swiss ProtO00522
Tested applications IF(IHC-P), FCM
Recommended dilutions IF(IHC-P)(1:50-200), FCM(1:20-100)
Crossreactivity Mouse, Rat, Human
Cross-reactive species details not every possible cross-reactivity is known, Due to limited amount of testing and knowledge
Background of the antigen Acts in concert with CDH5 to establish and maintain correct endothelial cell polarity and vascular lumen and these effects are mediated by recruitment and activation of the Par polarity complex and RAP1B, Facilitates the down-regulation of cyclin-D1 (CCND1) levels required for cell transition from proliferative growth to quiescence by preventing the accumulation of intracellular ROS through the modulation of FOXO1 and SOD2 levels, Inhibits endothelial proliferation, Microtubule-associated protein that binds to phosphatidylinositol 4, Negative regulator of angiogenesis, PARD3, Plays a role in integrin signaling via its interaction with ITGB1BP1, Plays an important role in the maintenance of the intracellular reactive oxygen species (ROS) homeostasis to prevent oxidative cellular damage, Promotes AKT phosphorylation in a NOTCH-dependent and independent manner, Regulates the homeostasis of intracellular ROS through an antioxidant pathway involving FOXO1 and SOD2, Required for the localization of phosphorylated PRKCZ, TIAM1 and RAP1B to the cell junction, and cell junction stabilization, and inhibits ERK1/2 phosphorylation indirectly through activation of the DELTA-NOTCH cascade, apoptosis, lumen formation and sprouting angiogenesis in primary endothelial cells, migration, this prevents the interaction between ITGB1 and ITGB1BP1, 5-bisphosphate (PIP2)-containing membranes in a GTP-bound RAP1-dependent manner, Component of the CCM signaling pathway which is a crucial regulator of heart and vessel formation and integrity (By similarity)
PurificationPurified by Protein A
Storage conditions 50% glycerol and 0, Keep refrigerated at 2 to 8 degrees Celcius for up to one year, 09% sodium azide, Store this antibody in aqueous buffered solution containing 1% BSA
Excitation emission499nm/519nm
Synonyms CAM
Properties ALEXA FLUOR they should be stored frozen at - 24°, Alexa Fluor 488 has the same range to that of fluorescein isothiocyanate (FITC), Also Alexa Fluor 488 is pH stable, As a result of this photo stability, If you buy Antibodies supplied by Bioss Primary Conjugated Antibodies, It is distinguished in the FL1 of a FACS-Calibur or FACScan, has a very high photo stability, it has turned into an antibody for fluorescent microscopy and FACS FLOW cytometry, yet the KRIT1 Antibody, C, C for long term storage and for short term at + 5°, For facs or microscopy Alexa 1 conjugate
ConjugationAlexa Fluor
Gene targetKRIT1
Short nameKRIT1 Antibody
Technique antibodies against human proteins, antibodies for, Antibody
LabelALEXA FLUOR 488
Alternative name ALEXA FLUOR 488, KRIT1 (Antibody to)
Alternative techniqueantibodies
Identity 1573
Gene KRIT1
Long gene name KRIT1, ankyrin repeat containing
Synonyms gene CCM1
Synonyms gene name cerebral cavernous malformations 1
Locus 7q21, 2
Discovery year 1995-06-02
GenBank acession AJ294850
Entrez gene record 889
Pubmed identfication 7604043 11342228
Classification Ankyrin repeat domain containing FERM domain containing
Havana BLAST/BLAT OTTHUMG00000131187
Locus Specific Databases LRG_650

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