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KRIT1 Antibody, FITC Conjugated

KRIT1 Antibody, FITC Conjugated size: 0.1ml 333

Supplier BIOSS PRIMARY CONJUGATED ANTIBODIES 1
Price 333
Size 0.1ml
Contact us Ask Component cell markers and DNA bp. markers are genetic markerser genes or DNA sequenceswith selection audit
Long name FITC Conjugated, KRIT1 Polyclonal Antibody
CategoryConjugated Primary Antibodies
ConjugationAnti-FITC Antibody
Host OrganismRabbit (Oryctolagus cuniculus)
Target AntigenKRIT1
SpecificityThis is a highly specific antibody against KRIT1
ModificationUnmodified
Modification siteNone
ClonalityPolyclonal
ClonePolyclonal antibody
Concentration1ug per 1ul
Immunogen_range650-700/736
Subcellular locationCell membrane
SourceKLH conjugated synthetic peptide derived from human KRIT1
Gene ID number889
Swiss ProtO00522
Tested applications IF(IHC-P), FCM
Recommended dilutions IF(IHC-P)(1:50-200), FCM(1:20-100)
Crossreactivity Mouse, Rat, Human
Crossreactive species details not every possible cross-reactivity is known, Due to limited amount of testing and knowledge
Antigen background Acts in concert with CDH5 to establish and maintain correct endothelial cell polarity and vascular lumen and these effects are mediated by recruitment and activation of the Par polarity complex and RAP1B, Facilitates the down-regulation of cyclin-D1 (CCND1) levels required for cell transition from proliferative growth to quiescence by preventing the accumulation of intracellular ROS through the modulation of FOXO1 and SOD2 levels, Inhibits endothelial proliferation, Microtubule-associated protein that binds to phosphatidylinositol 4, Negative regulator of angiogenesis, PARD3, Plays a role in integrin signaling via its interaction with ITGB1BP1, Plays an important role in the maintenance of the intracellular reactive oxygen species (ROS) homeostasis to prevent oxidative cellular damage, Promotes AKT phosphorylation in a NOTCH-dependent and independent manner, Regulates the homeostasis of intracellular ROS through an antioxidant pathway involving FOXO1 and SOD2, Required for the localization of phosphorylated PRKCZ, TIAM1 and RAP1B to the cell junction, and cell junction stabilization, and inhibits ERK1/2 phosphorylation indirectly through activation of the DELTA-NOTCH cascade, apoptosis, lumen formation and sprouting angiogenesis in primary endothelial cells, migration, this prevents the interaction between ITGB1 and ITGB1BP1, 5-bisphosphate (PIP2)-containing membranes in a GTP-bound RAP1-dependent manner, Component of the CCM signaling pathway which is a crucial regulator of heart and vessel formation and integrity (By similarity)
Purification methodThis antibody was purified via Protein A
Storage conditions 50% glycerol and 0, Store refrigerated at 2 to 8 degrees Celcius for up to 1 year, 09% sodium azide, Keep the antibody in an aqueous buffered solution containing 1% BSA
Excitation Emission494nm/518nm
Synonyms CAM
Properties Bioss Primary Conjugated Antibodies FITC is highly sensitive to pH extremes, FITC has a green emission that's usually collected at 530 nanometers, FITC has a high quantum yield (efficiency of energy transfer from absorption to emission fluorescence) and approximately half of the absorbed photons are emitted as fluorescent light, For fluorescent microscopy applications, This Bioss Primary Conjugated Antibodies Fluorescein isothiocyanate (FITC) antibody is currently after some BD antibodies the most commonly used fluorescent dye for FACS, When excited at 488 nanometers, its photo bleaching effects are not observed due to a very brief interaction at the laser intercept, the 1 FITC is seldom used as it photo bleaches rather quickly though in flow cytometry applications, the FL1 detector of a FACSCalibur or FACScan, C, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by Bioss Primary Conjugated Antibodies they should be stored frozen at - 24°
Gene targetKRIT1 Conjugated
Short name FITC Conjugated, KRIT1 Antibody
Technique Fluorescein, antibodies against human proteins, antibodies for, antibody Conjugates, Antibody
LabelFITC
Alternative name fluorecein coupled, KRIT1 (Antibody to)
Alternative techniqueantibodies
Identity 1573
Gene KRIT1
Long gene name KRIT1, ankyrin repeat containing
Synonyms gene CCM1
Synonyms gene name cerebral cavernous malformations 1
Locus 7q21, 2
Discovery year 1995-06-02
GenBank acession AJ294850
Entrez gene record 889
Pubmed identfication 7604043 11342228
Classification Ankyrin repeat domain containing FERM domain containing
Havana BLAST/BLAT OTTHUMG00000131187
Locus Specific Databases LRG_650

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