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Ku-70 Antibody

Ku-70 Antibody size: 0.1ml 263

Supplier BIOSS PRIMARY UNCONJUGATED ANTIBODIES
Price 263
Size 0.1ml
Contact us Ask Component cell markers and DNA bp. markers are genetic markerser genes or DNA sequenceswith selection audit
Long nameKu-70 Primary Polyclonal Antibody
Also known asKu-70 PAb
CategoryPrimary Antibodies
ConjugationUnconjugated
Target AntigenKu-70
SpecificityThis is a highly specific antibody against Ku-70
Modification(s)None
Modification site(s)Unmodified antibody
ClonalityPolyclonal antibody
Clone numberPolyclonal antibody
Concentration1ug per 1ul
SourceThis antibody was obtained by immunization of the host with KLH conjugated synthetic peptide derived from human Ku70
Gene ID number2547
Tested Applications IF(IHC-P), IHC-P, WB
Recommended dilutions IF(IHC-P)(1:50-200), IHC-P(1:100-500), WB(1:100-1000)
Cross reactivity Mouse, Rat, Human
Cross reactive species details not every possible cross-reactivity is known, Due to limited amount of testing and knowledge
Background of the target antigen High levels of auto to p70 and p80 have been found in some patients with systemic lupus erythematosus, It acts as the regulatory subunit of the DNA-dependent protein kinase complex DNA-PK by increasing the affinity of the catalytic subunit (PRKDC) for DNA, Ku70 heterodimerises with Ku80 to form the ATP-dependent DNA helicase II, The Ku70/80 heterodimer is also required for osteocalcin gene expression, The complex functions as a single-stranded DNA-dependent ATP-dependent helicase, The complex may be involved in the repair of nonhomologous DNA ends such as that required for double-strand break repair, The heterodimer plays a role in non-homologous end-joining (NHEJ) required for double-strand break repair and V(D)J recombination, [provided by RefSeq], a single stranded helicase that binds preferentially to fork-like ends of double-stranded DNA in a cell cycle-dependent manner, and V(D)J recombination, transposition, The p70/p80 autoantigen is a nuclear complex consisting of two subunits with molecular masses of approximately 70 and 80 kDa
Purification methodThis antibody was purified via Protein A
Storage conditions 50% glycerol and 0, Store at -20°, 09% sodium azide, C for up to 1 year, Keep the antibody in aqueous buffered solution containing 1% BSA
Synonym names 70 kDa subunit of Ku antigen, 70 kDa subunit of Ku antigen, 70kDa, ATP dependent DNA helicase 2 subunit 1, ATP dependent DNA helicase II 70 kDa subunit, CTC box binding factor 75 kDa subunit, CTC75, CTCBF, DNA repair protein XRCC6, G22P1, Ku 70, Ku autoantigen, Ku autoantigen 70kDa, Ku autoantigen p70 subunit, Ku p70, Ku70 DNA binding component of DNA-dependent proteinkinase complex thyroid autoantigen 70 kDa, Kup70, Lupus Ku autoantigen protein p70, ML8, TLAA, Thyroid autoantigen, Thyroid autoantigen 70kD Ku antigen, Thyroid lupus autoantigen, Thyroid lupus autoantigen p70, X ray repair complementing defective repair in Chinese hamster cells 6, XRCC 6, XRCC6, Ku70
PropertiesC, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by Bioss Primary Unconjugated Antibodies they should be stored frozen at - 24°
Gene targetKu-70
Short nameKu-70 Antibody
Technique antibodies against human proteins, antibodies for, Antibody
Alternative nameKu-70 (Antibody to)
Alternative techniqueantibodies

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