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Ku70 Antibody

Ku70 Antibody size: 0.08 ml 199

Supplier NJS POLY
Price 199
Size 0.08 ml
Contact us Ask Component cell markers and DNA bp. markers are genetic markerser genes or DNA sequenceswith selection audit
CategoryAntibody
Concentration pH 7, with 0, 09% sodium azide, 4, In 1X PBS
FormPurified
ConjugationUnconjugated
ClonePolyclonal antibody
Recognised antigenKu70
Host animalRabbit (Oryctolagus cuniculus)
ClonalityPolyclonal (rabbit origin)
Species reactivity Due to limited knowledge and inability to test the antibody against all known species, Mouse (Mus musculus) , we cannot guarantee that no other cross reactivity can occur, Human (Homo sapiens)
Tested applications ELISA, FACS, IHC, WB
Recommended dilutionsFlow Cytometry: 1:10-1:50, IHC (Paraffin): 1:10-1:50, Western blot: 1:1000
NotesTitration of the Ku70 antibody may be required due to differences in protocols and secondary/substrate sensitivity
Intented useThis Ku70 antibodyis to be used only for research purposes and not for diagnostics
Uniprot #P12956
PurityPurified
Description Binding to DNA may be mediated by p70, It has a role in chromosome translocation, It works in the 3'-5' direction, The DNA helicase II complex binds preferentially to fork-like ends of double-stranded DNA in a cell cycle-dependent manner, The Ku p70/p86 dimer acts as regulatory subunit of the DNA-dependent protein kinase complex DNA-PK by increasing the affinity of the catalytic subunit PRKDC to DNA by 100-fold, The Ku p70/p86 dimer is probably involved in stabilizing broken DNA ends and bringing them together, It is involved in DNA nonhomologous end joining (NHEJ) required for double-strand break repair and V(D)J recombination, Ku70 is a single stranded DNA-dependent ATP-dependent helicase
ImmunogenA portion of amino acids 432-461 from the human protein was used as the immunogen for this Ku70 antibody
Storage Celcius or lower, Cycles of freezing and thawing can denaturate the peptide chains of the antibodies and reduce their sensitivity and/or change their affinity, Prepare aliqotes in such a manner so that freeze-thaw cycles are minimized, Aliquot the Ku70 antibody and store frozen at -20 deg
PropertiesC, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by NJS poly they should be stored frozen at - 24°
Gene targetKu70
Short nameKu70 Antibody
Technique antibodies against human proteins, antibodies for, Antibody
Alternative nameKu70 (Antibody to)
Alternative techniqueantibodies
Identity 4055
Gene XRCC6
Long gene name X-ray repair cross complementing 6
Synonyms gene G22P1
Synonyms gene name thyroid autoantigen 70kD (Ku antigen) thyroid autoantigen 70kDa (Ku antigen) X-ray repair complementing defective repair in Chinese hamster cells 6
Synonyms D22S731 D22S671 KU70 ML8
Synonyms name 70kDa , Ku autoantigen
Locus 22q13, 2
Discovery year 1988-05-11
GenBank acession J04607
Entrez gene record 2547
Pubmed identfication 9200330 9223317
RefSeq identity NM_001469
Classification DNA helicases
Havana BLAST/BLAT OTTHUMG00000151190

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