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Ku80 Antibody

Ku80 Antibody size: 0.1mg 389

Supplier NJS POLY
Price 389
Size 0.1mg
Contact us Ask Component cell markers and DNA bp. markers are genetic markerser genes or DNA sequenceswith selection audit
CategoryAntibody
Concentration2ml sterile DI water, 5mg/ml if reconstituted with 0
FormAntigen affinity purified
ConjugationUnconjugated
ClonePolyclonal antibody
Recognised antigenKu80
Host animalRabbit (Oryctolagus cuniculus)
ClonalityPolyclonal (rabbit origin)
Species reactivity Due to limited knowledge and inability to test the antibody against all known species, we cannot guarantee that no other cross reactivity can occur, Human (Homo sapiens)
Tested applications ICC, IHC-P, WB
Recommended dilutions5-1ug/ml, 5-1ug/ml, 5-1ug/ml, IHC (Paraffin): 0, Immunocytochemistry: 0, Western blot: 0
Notes Titration of the Ku80 antibody may be required due to differences in protocols and secondary/substrate sensitivity, The stated application concentrations are suggested starting amounts
Intented useThis Ku80 antibodyis to be used only for research purposes and not for diagnostics
Uniprot #P13010
PurityAntigen affinity
Description 5), A rare microsatellite polymorphism in the protein is associated with cancer in patients of varying radiosensitivity, Complementing Defective, Functional inactivation of the second Ku80 allele results in cells with a drastically reduced doubling time, Human colon cancer cells heterozygous for Ku80 are haploinsufficient with an increase in polyploid cells, In Chinese Hamster, The XRCC5 gene encodes the 80-kD subunit of the Ku autoantigen, The locus is essential in human somatic tissue culture cells by experiments demonstration, a heterodimer which contributes to genomic integrity through its ability to bind DNA double-strand breaks and facilitate repair by the nonhomologous end joining(NHEJ) pathway, a reduction in cell proliferation, also known as Ku80 or Ku86, and a slight hypersensitivity to ionizing radiation, elevated p53 levels, is a protein that in humans, is encoded by the XRCC5 gene, XRCC5 (X-ray Repair
ImmunogenAn amino acid sequence from the C-terminus of human Ku80 (KFSEEQRFNNFLKAL) was used as the immunogen for this Ku80 antibody
Storage Avoid repeated freezing and thawing, Celcius or lower, Cycles of freezing and thawing can denaturate the peptide chains of the antibodies and reduce their sensitivity and/or change their affinity, For long-term, Prepare aliqotes in such a manner so that freeze-thaw cycles are minimized, aliquot and store at -20 deg, the Ku80 antibody can be stored for up to one month at 4oC, After reconstitution
PropertiesC, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by NJS poly they should be stored frozen at - 24°
Gene targetKu80
Short nameKu80 Antibody
Technique antibodies against human proteins, antibodies for, Antibody
Alternative nameKu80 (Antibody to)
Alternative techniqueantibodies
Identity 12833
Gene XRCC5
Long gene name X-ray repair cross complementing 5
Synonyms gene name 80kD) , Ku autoantigen, X-ray repair complementing defective repair in Chinese hamster cells 5 (double-strand-break rejoining
Synonyms KU80 KARP-1 Ku86 KUB2
Synonyms name 80kDa , Ku autoantigen
Locus 2q35
Discovery year 1992-01-22
GenBank acession AF039597
Entrez gene record 7520
Pubmed identfication 9636207 9214634
RefSeq identity NM_021141
Havana BLAST/BLAT OTTHUMG00000133059

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