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Lamin A Antibody

Lamin A Antibody size: 0.1mg 389

Supplier NJS POLY
Price 389
Size 0.1mg
Contact us Ask Component cell markers and DNA bp. markers are genetic markerser genes or DNA sequenceswith selection audit
CategoryAntibody
Concentration2ml sterile DI water, 5mg/ml if reconstituted with 0
FormAntigen affinity purified
ConjugationUnconjugated
ClonePolyclonal antibody
Recognised antigenLamin A
Host animalRabbit (Oryctolagus cuniculus)
ClonalityPolyclonal (rabbit origin)
Species reactivity Due to limited knowledge and inability to test the antibody against all known species, Mouse (Mus musculus), Rat , we cannot guarantee that no other cross reactivity can occur, Human (Homo sapiens)
Tested applications ICC, IHC-P, WB
Recommended dilutions5-1ug/ml, 5-1ug/ml, 5-1ug/ml, IHC (Paraffin): 0, Immunocytochemistry: 0, Western blot: 0
Notes Titration of the Lamin A antibody may be required due to differences in protocols and secondary/substrate sensitivity, The stated application concentrations are suggested starting points
Intented useThis Lamin A antibodyis to be used only for research purposes and not for diagnostics
Gene ID #4000
PurityAntigen affinity
Description A, Alternative splicing within exon 10 gives rise to two different mRNAs that code for pre-Lamin A and C, Deficiency is thus associated with both defective nuclear mechanics and impaired mechanically activated gene transcription, Lamin A/C is mapped to 1q21, The Lamin A/C (LMNA) gene contains 12 exons, There are three types of lamins, a protein network underlying the inner nuclear membrane that determines nuclear shape and size, and Hutchinson-Gilford progeria syndrome, dilated cardiomyopathy, 2-q21, 3 and mutations in this gene cause a variety of human diseases including Emery-Dreifuss muscular dystrophy, B and C, Lamins are structural protein components of the nuclear lamina
ImmunogenHuman partial recombinant protein (AA 481-646) was used as the immunogen for this Lamin A antibody
Storage Avoid repeated freezing and thawing, Celcius or lower, Cycles of freezing and thawing can denaturate the peptide chains of the antibodies and reduce their sensitivity and/or change their affinity, For long-term, Prepare aliqotes in such a manner so that freeze-thaw cycles are minimized, aliquot and store at -20 deg, the Lamin A antibody can be stored for up to one month at 4oC, After reconstitution
PropertiesC, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by NJS poly they should be stored frozen at - 24°
Gene targetLamin A
Short nameLamin A Antibody
Technique antibodies against human proteins, antibodies for, Antibody
Alternative nameLamin A (Antibody to)
Alternative techniqueantibodies
Identity 9450
Gene PRO1
Long gene name lamin A/C
Synonyms gene LMN1 CMD1A LGMD1B LMNL1
Synonyms gene name cardiomyopathy, dilated 1A (autosomal dominant) limb girdle muscular dystrophy 1B (autosomal dominant) progeria 1 (Hutchinson-Gilford type) lamin A/C-like 1
Synonyms HGPS MADA LMNA
Synonyms name mandibuloacral dysplasia type A
Locus 1q22
Discovery year 1992-04-09
GenBank acession BC014507
Entrez gene record 4000
Pubmed identfication 8511676 8838815 12702809
RefSeq identity NM_170707
Classification Lamins
Havana BLAST/BLAT OTTHUMG00000013961
Locus Specific Databases Inherited Peripheral Neuropathies Mutation Database Leiden Muscular Dystrophy Pages UMD Locus Specific Databases Leiden Muscular Dystrophy pages LRG_254

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