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LATS1 (Thr1079) Antibody, Biotin Conjugated

LATS1 (Thr1079) Antibody, Biotin Conjugated size: 0.1ml 350

Supplier BIOSS PRIMARY CONJUGATED ANTIBODIES 1
Price 350
Size 0.1ml
Contact us Ask Component cell markers and DNA bp. markers are genetic markerser genes or DNA sequenceswith selection audit
Long name Biotin Conjugated, LATS1 (Thr1079) Polyclonal Antibody
CategoryConjugated Primary Antibodies
ConjugationBiotinylated
Host OrganismRabbit (Oryctolagus cuniculus)
Target AntigenLATS1 Thr1079
Specificity This sequence will cross react with LATS2 if phosphorylated at Thr1041, This is a highly specific antibody against LATS1 Thr1079
ModificationPhosphorylation
Modification siteThr1079
ClonalityPolyclonal
ClonePolyclonal antibody
Concentration1ug per 1ul
Immunogen_range1060-1100/1130
Subcellular locationCytoplasm
SourceKLH conjugated synthetic phosphopeptide derived from human LATS1 around the phosphorylation site of Thr1079
Gene ID number9113
Swiss ProtO95835
Tested applications IHC-P, WB
Recommended dilutions IHC-P(1:100-500), WB(1:100-1000)
Crossreactivity Mouse, Rat, Human
Crossreactive species details not every possible cross-reactivity is known, Due to limited amount of testing and knowledge
Antigen background Acts as a tumor suppressor which plays a critical role in maintenance of ploidy through its actions in both mitotic progression and the G1 tetraploidy checkpoint, Affects cytokinesis by regulating actin polymerization through negative modulation of LIMK1, Involved in the control of p53 expression, May also play a role in endocrine function, Negatively regulates G2/M transition by down-regulating CDK1 kinase activity, Phosphorylation of YAP1 by LATS1 inhibits its translocation into the nucleus to regulate cellular genes important for cell proliferation, The core of this pathway is composed of a kinase cascade wherein STK3/MST2 and STK4/MST1, and cell migration, cell death, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ, Negative regulator of YAP1 in the Hippo signaling pathway that plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis
Purification methodThis antibody was purified via Protein A
Storage conditions 50% glycerol and 0, Store refrigerated at 2 to 8 degrees Celcius for up to 1 year, 09% sodium azide, Keep the antibody in an aqueous buffered solution containing 1% BSA
Excitation EmissionN/A
Synonyms WARTS
Properties Avidin and Streptavidin bind to the small biotin and are couple to HRP or AP for ELISA, Biotin conjugates can be detected by horseradish peroxidase, To break the streptavidin Biotin bond we suggest to use a 6 molar guanidine HCl solution with acidity of pH 1, alkaline phosphatase substrates or anti biotin conjugated antibodies, 6, C, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by Bioss Primary Conjugated Antibodies they should be stored frozen at - 24°
Gene targetLATS1 (Thr1079) Conjugated
Short name Conjugated, LATS1 (Thr1079) Antibody
Technique antibodies against human proteins, antibodies for, antibody Conjugates, Antibody
LabelBiotin
Alternative name biotinilated coupled, LATS1 (Thr1079) (Antibody to)
Alternative techniqueantibodies
Identity 6514
Gene LATS1
Long gene name large tumor suppressor kinase 1
Synonyms gene name Drosophila) homolog 1 LATS, LATS (large tumor suppressor, homolog 1 (Drosophila) , large tumor suppressor
Locus 6q25, 1
Discovery year 1999-02-18
GenBank acession AF104413
Entrez gene record 9113
Pubmed identfication 9988268 15122335
RefSeq identity NM_004690
Havana BLAST/BLAT OTTHUMG00000016437

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