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LEF-1 Antibody

LEF-1 Antibody size: 0.1ml 263

Supplier BIOSS PRIMARY UNCONJUGATED ANTIBODIES
Price 263
Size 0.1ml
Contact us Ask Component cell markers and DNA bp. markers are genetic markerser genes or DNA sequenceswith selection audit
Long nameLEF-1 Primary Polyclonal Antibody
Also known asLEF-1 PAb
CategoryPrimary Antibodies
ConjugationUnconjugated
Target AntigenLEF-1
SpecificityThis is a highly specific antibody against LEF-1
Modification(s)None
Modification site(s)Unmodified antibody
ClonalityPolyclonal antibody
Clone numberPolyclonal antibody
Concentration1ug per 1ul
Immunogen range350-399/399
Subcellular locationNucleus
SourceThis antibody was obtained by immunization of the host with KLH conjugated synthetic peptide derived from human LEF-1
Gene ID number51176
Swiss ProtQ9UJU2
Tested Applications IF(IHC-P), IHC-P, WB
Recommended dilutions IF(IHC-P)(1:50-200), IHC-P(1:100-500), WB(1:100-1000)
Cross reactivity Mouse, Rat, Human
Cross reactive species details not every possible cross-reactivity is known, Due to limited amount of testing and knowledge
Background of the target antigen Activates transcription of target genes in the presence of CTNNB1 and EP3, Binds DNA in a sequence-specific manner, Isoform 1 transcriptionally activates MYC and CCND1 expression and enhances proliferation of pancreatic tumor cells, Isoform 3 lacks the CTNNB1 interaction domain and may be an antagonist for Wnt signaling, Isoform 5 transcriptionally activates the fibronectin promoter, May play a role in hair cell differentiation and follicle morphogenesis, PIAG antagonizes both Wnt-dependent and Wnt-independent activation by LEF1 (By similarity), Regulates T-cell receptor alpha enhancer function, TLE1, TLE2, TLE3 and TLE4 repress transactivation mediated by LEF1 and CTNNB1, and is involved in reducing cellular aggregation and increasing cell migration of pancreatic cancer cells, binds to and represses transcription from the E-cadherin promoter in a CTNNB1-independent manner, Participates in the Wnt signaling pathway
Purification methodThis antibody was purified via Protein A
Storage conditions 50% glycerol and 0, Store at -20°, 09% sodium azide, C for up to 1 year, Keep the antibody in aqueous buffered solution containing 1% BSA
Synonym names LEF1, Lymphoid enhancer-binding factor 1, T cell-specific transcription factor 1-alpha, TCF1, TCF1-alpha, TCF1ALPHA, TCF7L3, LEF-1
PropertiesC, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by Bioss Primary Unconjugated Antibodies they should be stored frozen at - 24°
Gene targetLEF-1
Short nameLEF-1 Antibody
Technique antibodies against human proteins, antibodies for, Antibody
Alternative nameLEF-1 (Antibody to)
Alternative techniqueantibodies

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