Filters

LEO1 Antibody

LEO1 Antibody size: 0.1ml 263

Supplier BIOSS PRIMARY UNCONJUGATED ANTIBODIES
Price 263
Size 0.1ml
Contact us Ask Component cell markers and DNA bp. markers are genetic markerser genes or DNA sequenceswith selection audit
Long nameLEO1 Primary Polyclonal Antibody
Also known asLEO1 PAb
CategoryPrimary Antibodies
ConjugationUnconjugated
Target AntigenLEO1
SpecificityThis is a highly specific antibody against LEO1
Modification(s)None
Modification site(s)Unmodified antibody
ClonalityPolyclonal antibody
Clone numberPolyclonal antibody
Concentration1ug per 1ul
Immunogen range500-550/666
Subcellular locationNucleus
SourceThis antibody was obtained by immunization of the host with KLH conjugated synthetic peptide derived from human LEO1
Gene ID number123169
Swiss ProtQ8WVC0
Tested Applications IF(IHC-P), IHC-P, WB
Recommended dilutions IF(IHC-P)(1:50-200), IHC-P(1:100-500), WB(1:100-1000)
Cross reactivity Mouse, Rat, Human
Cross reactive species details not every possible cross-reactivity is known, Due to limited amount of testing and knowledge
Background of the target antigen Connects PAF1C to Wnt signaling, In case of infection by influenza A strain H3N2, Involved in polyadenylation of mRNA precursors, PAF1C associates with RNA polymerase II through interaction with POLR2A CTD non-phosphorylated and 'Ser-2'- and 'Ser-5'-phosphorylated forms and is involved in transcriptional elongation, PAF1C associates with viral NS1 protein, PAF1C is involved in hematopoiesis and stimulates transcriptional activity of KMT2A/MLL1, PAF1C is involved in histone modifications such as ubiquitination of histone H2B and methylation on histone H3 'Lys-4' (H3K4me3), PAF1C is involved in mRNA 3' end formation probably through association with cleavage and poly(A) factors, PAF1C is required for transcription of Hox and Wnt target genes, PAF1C recruits the RNF20/40 E3 ubiquitin-protein ligase complex and the E2 enzyme UBE2A or UBE2B to chromatin which mediate monoubiquitination of 'Lys-120' of histone H2B (H2BK120ub1), UB2A/B-mediated H2B ubiquitination is proposed to be coupled to transcription, acting both indepentently and synergistically with TCEA1 and in cooperation with the DSIF complex and HTATSF1, it promotes leukemogenesis through association with KMT2A/MLL1-rearranged oncoproteins, such as KMT2A/MLL1-MLLT3/AF9 and KMT2A/MLL1-MLLT1/ENL, thereby regulating gene transcription, Component of the PAF1 complex (PAF1C) which has multiple functions during transcription by RNA polymerase II and is implicated in regulation of development and maintenance of embryonic stem cell pluripotency
Purification methodThis antibody was purified via Protein A
Storage conditions 50% glycerol and 0, Store at -20°, 09% sodium azide, C for up to 1 year, Keep the antibody in aqueous buffered solution containing 1% BSA
Synonym names LEO1, RNA polymerase-associated protein LEO1, Replicative senescence down-regulated leo1-like protein, RDL
PropertiesC, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by Bioss Primary Unconjugated Antibodies they should be stored frozen at - 24°
Gene targetLEO1
Short nameLEO1 Antibody
Technique antibodies against human proteins, antibodies for, Antibody
Alternative nameLEO1 (Antibody to)
Alternative techniqueantibodies
Identity 30401
Gene LEO1
Long gene name LEO1 homolog, Paf1/RNA polymerase II complex component
Synonyms gene name Leo1, Paf1/RNA polymerase II complex component, cerevisiae) , homolog (S
Locus 15q21, 2
Discovery year 2005-07-20
GenBank acession AY302186
Entrez gene record 123169
Pubmed identfication 15632063 24038468
RefSeq identity NM_138792
Classification Paf1/RNA polymerase II complex
Havana BLAST/BLAT OTTHUMG00000131843

Similar products

Subscribe to our Newsletter