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LFA-1 Antibody

LFA-1 Antibody size: 0.1mg 406

Supplier NJS POLY
Price 406
Size 0.1mg
Contact us Ask Component cell markers and DNA bp. markers are genetic markerser genes or DNA sequenceswith selection audit
CategoryAntibody
Concentration2ml sterile DI water, 5mg/ml if reconstituted with 0
FormAntigen affinity purified
ConjugationUnconjugated
ClonePolyclonal antibody
Recognised antigenLFA-1
Host animalRabbit (Oryctolagus cuniculus)
ClonalityPolyclonal (rabbit origin)
Species reactivity Due to limited knowledge and inability to test the antibody against all known species, we cannot guarantee that no other cross reactivity can occur, Human (Homo sapiens)
Tested applications IHC-P, WB
Recommended dilutions5-1ug/ml, 5-1ug/ml, IHC (Paraffin): 0, Western blot: 0
Notes Titration of the LFA-1 antibody may be required due to differences in protocols and secondary/substrate sensitivity, The stated application concentrations are suggested starting amounts
Intented useThis LFA-1 antibodyis to be used only for research purposes and not for diagnostics
Gene ID #3689
PurityAntigen affinity
Description Although the protein is expressed on the cell surface at normal levels and is capable of function following extracellular stimulation, In humans lack of LFA-1 causes Leukocyte Adhesion Deficiency, It is an integrin protein that belongs to the class of cell membrane glycoproteins, The beta-2 integrin chain gene is designated ITGB2 and the leukocyte antigen has been designated LFA-1/CD18, The expression of LFA-1 is increased in lymphoblastoid cells from persons with Down syndrome, a disease defined by a lack of leukocyte extravasation from blood into tissues, also known as CD18, consistent with the location of the gene on chromosome 21, is a protein that in humans is encoded by the ITGB2 gene, it could not be activated via the 'inside-out' signaling pathways, Lymphocyte function associated antigen 1
ImmunogenHuman partial recombinant protein (AA 404-769) was used as the immunogen for this LFA-1 antibody
Storage Avoid repeated freezing and thawing, Celcius or lower, Cycles of freezing and thawing can denaturate the peptide chains of the antibodies and reduce their sensitivity and/or change their affinity, For long-term, Prepare aliqotes in such a manner so that freeze-thaw cycles are minimized, aliquot and store at -20 deg, the LFA-1 antibody can be stored for up to one month at 4oC, After reconstitution
PropertiesC, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by NJS poly they should be stored frozen at - 24°
Gene targetLFA-1
Short nameLFA-1 Antibody
Technique antibodies against human proteins, antibodies for, Antibody
Alternative nameLFA-1 (Antibody to)
Alternative techniqueantibodies
Identity 6148
Gene ITGAL
Long gene name integrin subunit alpha L
Synonyms gene CD11A
Synonyms gene name alpha L (antigen CD11A (p180), alpha polypeptide) , integrin, lymphocyte function-associated antigen 1
Synonyms LFA-1
Synonyms name alpha polypeptide , antigen CD11A (p180) lymphocyte function-associated antigen 1
Locus 16p11, 2
Discovery year 1986-01-01
Entrez gene record 3683
Pubmed identfication 3284962
Classification Integrin alpha subunits CD molecules
Havana BLAST/BLAT OTTHUMG00000176964

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