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LIMK1 Antibody

LIMK1 Antibody size: 0.1ml 263

Supplier BIOSS PRIMARY UNCONJUGATED ANTIBODIES
Price 263
Size 0.1ml
Contact us Ask Component cell markers and DNA bp. markers are genetic markerser genes or DNA sequenceswith selection audit
Long nameLIMK1 Primary Polyclonal Antibody
Also known asLIMK1 PAb
CategoryPrimary Antibodies
ConjugationUnconjugated
Target AntigenLIMK1
SpecificityThis is a highly specific antibody against LIMK1
Modification(s)None
Modification site(s)Unmodified antibody
ClonalityPolyclonal antibody
Clone numberPolyclonal antibody
Concentration1ug per 1ul
Immunogen range465-512/647
Subcellular location Nucleus, Cytoplasm
SourceThis antibody was obtained by immunization of the host with KLH conjugated synthetic peptide derived from human LIMK1
Gene ID number3984
Swiss ProtP53667
Tested Applications IF(IHC-P), IHC-P, WB
Recommended dilutions IF(IHC-P)(1:50-200), IHC-P(1:100-500), WB(1:100-1000)
Cross reactivity Mouse, Rat, Human
Cross reactive species details not every possible cross-reactivity is known, Due to limited amount of testing and knowledge
Background of the target antigen Activated by upstream kinases including ROCK1, Acts downstream of several Rho family GTPase signal transduction pathways, In this way LIMK1 regulates several actin-dependent biological processes including cell motility, Isoform 3 has a dominant negative effect on actin cytoskeletal changes, LIMK1 subsequently phosphorylates and inactivates the actin binding/depolymerizing factors cofilin-1/CFL1, PAK1 and PAK4, Phosphorylates TPPP on serine residues, Required for atypical chemokine receptor ACKR2-induced phosphorylation of cofilin (CFL1), Stimulates axonal outgrowth and may be involved in brain development, and differentiation, and stabilizing the actin cytoskeleton, cell cycle progression, cofilin-2/CFL2 and destrin/DSTN, thereby preventing the cleavage of filamentous actin (F-actin), thereby promoting microtubule disassembly, which phosphorylate LIMK1 on a threonine residue located in its activation loop, Serine/threonine-protein kinase that plays an essential role in the regulation of actin filament dynamics
Purification methodThis antibody was purified via Protein A
Storage conditions 50% glycerol and 0, Store at -20°, 09% sodium azide, C for up to 1 year, Keep the antibody in aqueous buffered solution containing 1% BSA
Synonym names LIM domain kinase 1, LIMK-1, LIMK1, LIMK
PropertiesC, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by Bioss Primary Unconjugated Antibodies they should be stored frozen at - 24°
Gene targetLIMK1
Short nameLIMK1 Antibody
Technique antibodies against human proteins, antibodies for, Antibody
Alternative nameLIMK1 (Antibody to)
Alternative techniqueantibodies
Identity 6613
Gene LIMK1
Long gene name LIM domain kinase 1
Synonyms LIMK
Locus 7q11, 23
Discovery year 1996-03-14
GenBank acession D26309
Entrez gene record 3984
Pubmed identfication 8673124 8812460
RefSeq identity NM_002314
Classification LIM domain containing PDZ domain containing
Havana BLAST/BLAT OTTHUMG00000023448

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