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LIMK1 Antibody, Cy7 Conjugated

LIMK1 Antibody, Cy7 Conjugated size: 0.1ml 350

Supplier BIOSS PRIMARY CONJUGATED ANTIBODIES 1
Price 350
Size 0.1ml
Contact us Ask Component cell markers and DNA bp. markers are genetic markerser genes or DNA sequenceswith selection audit
Long name Cy7 Conjugated, LIMK1 Polyclonal Antibody
CategoryConjugated Primary Antibodies
ConjugationCy7
Host OrganismRabbit (Oryctolagus cuniculus)
Target AntigenLIMK1
SpecificityThis is a highly specific antibody against LIMK1
ModificationUnmodified
Modification siteNone
ClonalityPolyclonal
ClonePolyclonal antibody
Concentration1ug per 1ul
Immunogen_range465-512/647
Subcellular location Nucleus, Cytoplasm
SourceKLH conjugated synthetic peptide derived from human LIMK1
Gene ID number3984
Swiss ProtP53667
Tested applicationsIF(IHC-P)
Recommended dilutionsIF(IHC-P)(1:50-200)
Crossreactivity Mouse, Rat, Human
Crossreactive species details not every possible cross-reactivity is known, Due to limited amount of testing and knowledge
Antigen background Activated by upstream kinases including ROCK1, Acts downstream of several Rho family GTPase signal transduction pathways, In this way LIMK1 regulates several actin-dependent biological processes including cell motility, Isoform 3 has a dominant negative effect on actin cytoskeletal changes, LIMK1 subsequently phosphorylates and inactivates the actin binding/depolymerizing factors cofilin-1/CFL1, PAK1 and PAK4, Phosphorylates TPPP on serine residues, Required for atypical chemokine receptor ACKR2-induced phosphorylation of cofilin (CFL1), Stimulates axonal outgrowth and may be involved in brain development, and differentiation, and stabilizing the actin cytoskeleton, cell cycle progression, cofilin-2/CFL2 and destrin/DSTN, thereby preventing the cleavage of filamentous actin (F-actin), thereby promoting microtubule disassembly, which phosphorylate LIMK1 on a threonine residue located in its activation loop, Serine/threonine-protein kinase that plays an essential role in the regulation of actin filament dynamics
Purification methodThis antibody was purified via Protein A
Storage conditions 50% glycerol and 0, Store refrigerated at 2 to 8 degrees Celcius for up to 1 year, 09% sodium azide, Keep the antibody in an aqueous buffered solution containing 1% BSA
Excitation Emission743nm/767nm
Synonyms LIMK
PropertiesC, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by Bioss Primary Conjugated Antibodies they should be stored frozen at - 24°
ConjugatedThese antibodies are excite for emission at 650 nm and detected at a 676 nm wavelengths
Gene targetLIMK1 Conjugated
Short name Conjugated, LIMK1 Antibody
Technique antibodies against human proteins, antibodies for, antibody Conjugates, Antibody
LabelCy7
Alternative name cyanine 7 coupled, LIMK1 (Antibody to)
Alternative techniqueantibodies
Identity 6613
Gene LIMK1
Long gene name LIM domain kinase 1
Locus 7q11, 23
Discovery year 1996-03-14
GenBank acession D26309
Entrez gene record 3984
Pubmed identfication 8673124 8812460
RefSeq identity NM_002314
Classification LIM domain containing PDZ domain containing
Havana BLAST/BLAT OTTHUMG00000023448

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