LIN28 Antibody

LIN28 Antibody size: 0.08 ml 199

Price 199

Size 0.08 ml

Contact us Ask Component cell markers and DNA bp. markers are genetic markerser genes or DNA sequenceswith selection audit

Category	Antibody
Concentration	pH 7, with 0, 09% sodium azide, 4, In 1X PBS
Form	Purified
Conjugation	Unconjugated
Clone	Polyclonal antibody
Recognised antigen	LIN28
Host animal	Rabbit (Oryctolagus cuniculus)
Clonality	Polyclonal (rabbit origin)
Species reactivity	Due to limited knowledge and inability to test the antibody against all known species, Mouse (Mus musculus) , we cannot guarantee that no other cross reactivity can occur, Human (Homo sapiens)
Tested applications	ELISA, FACS, WB
Recommended dilutions	Flow Cytometry: 1:10-1:50, Western blot: 1:1000
Notes	Titration of the LIN28 antibody may be required due to differences in protocols and secondary/substrate sensitivity
Intented use	This LIN28 antibodyis to be used only for research purposes and not for diagnostics
Uniprot #	Q9H9Z2
Purity	Purified
Description	ARBP/36B4 ribosomal protein mRNA and its own mRNA, Acts as a suppressor of microRNA (miRNA) biogenesis by specifically binding the precursor let-7 (pre-let-7), Acts by binding pre-let-7 and recruiting ZCCHC11/TUT4 uridylyltransferase, Also recognizes and binds non pre-let-7 pre-miRNAs that contain the 5'-GGAG-3' motif in the terminal loop, Binds IGF2 mRNA, Degradation of pre-let-7 in embryonic stem (ES) cells contributes to the maintenance of ES cells, Essential for skeletal muscle differentiation program through the translational up-regulation of IGF2 expression (By similarity), In contrast, Its association with the translational machinery and target mRNAs results in an increased number of initiation events per molecule of mRNA and, LIN28A down-regulation in neural stem cells by miR-125, MYOD1 mRNA, Specifically recognizes the 5'-GGAG-3' motif in the terminal loop of pre-let-7, Uridylated pre-let-7 miRNAs fail to be processed by Dicer and undergo degradation, a miRNA precursor, allows the processing of pre-let-7, driving specific mRNAs to polysomes and thus increasing the efficiency of protein synthesis, in stabilizing the mRNAs, indirectly, leading to the terminal uridylation of pre-let-7, leading to their terminal uridylation and subsequent degradation, Acts as a 'translational enhancer'
Immunogen	This LIN28A antibody was produced from rabbits immunized with a His fusion protein from human LIN28A
Storage	Celcius or lower, Cycles of freezing and thawing can denaturate the peptide chains of the antibodies and reduce their sensitivity and/or change their affinity, Prepare aliqotes in such a manner so that freeze-thaw cycles are minimized, Aliquot the LIN28 antibody and store frozen at -20 deg
Properties	C, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by NJS poly they should be stored frozen at - 24°
Gene target	LIN28
Short name	LIN28 Antibody
Technique	antibodies against human proteins, antibodies for, Antibody
Alternative name	LIN28 (Antibody to)
Alternative technique	antibodies
Identity	15986
Gene	LIN28A
Long gene name	lin-28 homolog A
Synonyms gene	LIN28
Synonyms gene name	elegans) , lin-28 homolog (C
Synonyms	LIN-28 FLJ12457 ZCCHC1 CSDD1
Locus	1p36, 11
Discovery year	2003-07-21
GenBank acession	AF521099
Entrez gene record	79727
Pubmed identfication	12798299
RefSeq identity	NM_024674
Classification	Zinc fingers CCHC-type
Havana BLAST/BLAT	OTTHUMG00000003550

LIN28 Antibody

LIN28 Antibody size: 0.08 ml 199

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