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Livin Antibody

Livin Antibody size: 0.1ml 263

Supplier BIOSS PRIMARY UNCONJUGATED ANTIBODIES
Price 263
Size 0.1ml
Contact us Ask Component cell markers and DNA bp. markers are genetic markerser genes or DNA sequenceswith selection audit
Long nameLivin Primary Polyclonal Antibody
Also known asLivin PAb
CategoryPrimary Antibodies
ConjugationUnconjugated
Target AntigenLivin
SpecificityThis is a highly specific antibody against Livin
Modification(s)None
Modification site(s)Unmodified antibody
ClonalityPolyclonal antibody
Clone numberPolyclonal antibody
Concentration1ug per 1ul
Immunogen range100-150/298
Subcellular location Nucleus, Cytoplasm
SourceThis antibody was obtained by immunization of the host with KLH conjugated synthetic peptide derived from human Livin
Gene ID number79444
Swiss ProtQ96CA5
Tested Applications IF(IHC-P), IHC-P, WB
Recommended dilutions IF(IHC-P)(1:50-200), IHC-P(1:100-500), WB(1:100-1000)
Cross reactivity Mouse, Rat, Human
Cross reactive species details not every possible cross-reactivity is known, Due to limited amount of testing and knowledge
Background of the target antigen As it is a weak caspase inhibitor, CASP7 and CASP9, In vitro, Isoform 1 blocks staurosporine-induced apoptosis, Isoform 2 blocks etoposide-induced apoptosis, Isoform 2 protects against natural killer (NK) cell killing whereas isoform 1 augments killing, Its anti-apoptotic activity is mediated through the inhibition of CASP3, May contribute to caspase inhibition, Protects against apoptosis induced by TNF or by chemical agents such as adriamycin, Suppression of apoptosis is mediated by activation of MAPK8/JNK1, This activation depends on TAB1 and NR2C2/TAK1, and cell cycle control, and possibly also of MAPK9/JNK2, as well as by its E3 ubiquitin-protein ligase activity, by blocking the ability of DIABLO/SMAC to disrupt XIAP/BIRC4-caspase interactions, cell proliferation, etoposide or staurosporine, inhibits CASP3 and proteolytic activation of pro-CASP9, its anti-apoptotic activity is thought to be due to its ability to ubiquitinate DIABLO/SMAC targeting it for degradation thereby promoting cell survival, Apoptotic regulator capable of exerting proapoptotic and anti-apoptotic activities and plays crucial roles in apoptosis
Purification methodThis antibody was purified via Protein A
Storage conditions 50% glycerol and 0, Store at -20°, 09% sodium azide, C for up to 1 year, Keep the antibody in aqueous buffered solution containing 1% BSA
Synonym names BIRC7, Baculoviral IAP repeat-containing protein 7, Kidney inhibitor of apoptosis protein, LIVIN, ML-IAP, MLIAP, Melanoma inhibitor of apoptosis protein, RING finger protein 50, RNF50, UNQ5800/PRO19607/PRO21344, KIAP
PropertiesC, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by Bioss Primary Unconjugated Antibodies they should be stored frozen at - 24°
Gene targetLivin
Short nameLivin Antibody
Technique antibodies against human proteins, antibodies for, Antibody
Alternative nameLivin (Antibody to)
Alternative techniqueantibodies
Identity 13702
Gene BIRC7
Long gene name baculoviral IAP repeat containing 7
Synonyms gene name baculoviral IAP repeat-containing 7
Synonyms mliap ML-IAP KIAP RNF50
Synonyms name melanoma inhibitor of apoptosis protein kidney inhibitor of apoptosis protein livin inhibitor-of-apoptosis livin
Locus 20q13, 33
Discovery year 2001-03-06
GenBank acession AF301009
Entrez gene record 79444
Pubmed identfication 11024045 11162435
RefSeq identity NM_139317
Classification Baculoviral IAP repeat containing Ring finger proteins
Havana BLAST/BLAT OTTHUMG00000032957

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