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LKB1 (Thr363) Antibody

LKB1 (Thr363) Antibody size: 0.1ml 281

Supplier BIOSS PRIMARY UNCONJUGATED ANTIBODIES
Price 281
Size 0.1ml
Contact us Ask Component cell markers and DNA bp. markers are genetic markerser genes or DNA sequenceswith selection audit
Long nameLKB1 (Thr363) Primary Polyclonal Antibody
Also known asLKB1 (Thr363) PAb
CategoryPrimary Antibodies
ConjugationUnconjugated
Target AntigenLKB1 Thr363
SpecificityThis is a highly specific antibody against LKB1 Thr363
Modification(s)Phosphorylation
Modification site(s)Thr363
ClonalityPolyclonal antibody
Clone numberPolyclonal antibody
Concentration1ug per 1ul
Immunogen range340-390/433
Subcellular location Cell membrane, Mitochondrion, Nucleus, Cytoplasm
SourceKLH conjugated synthetic phosphopeptide derived from human LKB1 around the phosphorylation site of Thr363 [IY(p-T)QD]
Gene ID number6794
Swiss ProtQ15831
Tested Applications IF(IHC-P), IHC-P, WB
Recommended dilutions IF(IHC-P)(1:50-200), IHC-P(1:100-500), WB(1:100-1000)
Cross reactivity Mouse, Rat, Human
Cross reactive species details not every possible cross-reactivity is known, Due to limited amount of testing and knowledge
Background of the target antigen Able to phosphorylate p53/TP53, Acts as a key upstream regulator of AMPK by mediating phosphorylation and activation of AMPK catalytic subunits PRKAA1 and PRKAA2 and thereby regulates processes including: inhibition of signaling pathways that promote cell growth and proliferation when energy levels are low, Acts by phosphorylating the T-loop of AMPK family proteins, Also acts as a mediator of p53/TP53-dependent apoptosis via interaction with p53/TP53: translocates to the mitochondrion during apoptosis and regulates p53/TP53-dependent apoptosis pathways, Also acts as a regulator of cellular polarity by remodeling the actin cytoskeleton, Also phosphorylates non-AMPK family proteins such as STRADA, BRSK1, BRSK2, In vein endothelial cells, Involved in DNA damage response: interacts with p53/TP53 and recruited to the CDKN1A/WAF1 promoter to participate in transcription activation, Isoform 2: Has a role in spermiogenesis, MARK1, MARK2, MARK3, MARK4, NUAK1, NUAK2, PRKAA2, PTEN and possibly p53/TP53, Required for cortical neuron polarization by mediating phosphorylation and activation of BRSK1 and BRSK2, SIK1, SIK2, SIK3 and SNRK but not MELK, activation of autophagy when cells undergo nutrient deprivation, and B-cell differentiation in the germinal center in response to DNA damage, apoptosis and DNA damage response, cell polarity, glucose homeostasis in liver, inhibits PI3K/Akt signaling activity and thus induces apoptosis in response to the oxidant peroxynitrite (in vitro), leading to axon initiation and specification, the relevance of such result in vivo is however unclear and phosphorylation may be indirect and mediated by downstream STK11/LKB1 kinase NUAK1, thereby playing a role in various processes such as cell metabolism, thus promoting their activity: phosphorylates PRKAA1, Tumor suppressor serine/threonine-protein kinase that controls the activity of AMP-activated protein kinase (AMPK) family members
Purification methodThis antibody was purified via Protein A
Storage conditions 50% glycerol and 0, Store at -20°, 09% sodium azide, C for up to 1 year, Keep the antibody in aqueous buffered solution containing 1% BSA
Synonym names LKB1, Liver kinase B1, Renal carcinoma antigen NY-REN-19, STK11, Serine/threonine-protein kinase STK11, hLKB1, PJS
PropertiesC, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by Bioss Primary Unconjugated Antibodies they should be stored frozen at - 24°
Gene targetLKB1 (Thr363)
Short nameLKB1 (Thr363) Antibody
Technique antibodies against human proteins, antibodies for, Antibody
Alternative nameLKB1 (Thr363) (Antibody to)
Alternative techniqueantibodies
Identity 11389
Gene STK11
Long gene name serine/threonine kinase 11
Synonyms gene name serine/threonine kinase 11 (Peutz-Jeghers syndrome)
Synonyms PJS LKB1
Synonyms name polarization-related protein LKB1
Locus 19p13, 3
Discovery year 1998-01-21
GenBank acession U63333
Entrez gene record 6794
Pubmed identfication 9425897
RefSeq identity NM_000455
Havana BLAST/BLAT OTTHUMG00000180118
Locus Specific Databases LRG_319

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