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LKB1 (Thr363) Antibody, ALEXA FLUOR 350

LKB1 (Thr363) Antibody, ALEXA FLUOR 350 size: 100ul 350

Supplier BIOSS PRIMARY CONJUGATED ANTIBODIES
Price 350
Size 100ul
Contact us Ask Component cell markers and DNA bp. markers are genetic markerser genes or DNA sequenceswith selection audit
Long name ALEXA FLUOR 350 Conjugated, LKB1 (Thr363) Polyclonal Antibody
Also known asAnti-LKB1 Thr363 PAb ALEXA FLUOR 350
CategoryConjugated Primary Antibodies
Conjugated with 350, ALEXA FLUOR®
Host OrganismRabbit (Oryctolagus cuniculus)
Target AntigenLKB1 Thr363
SpecificityThis is a highly specific antibody against LKB1 Thr363
ModificationPhosphorylation
Modification SiteThr363
ClonalityPolyclonal
ClonePolyclonal antibody
Concentration1ug per 1ul
Immunogen range340-390/433
Subcellular location Cell membrane, Mitochondrion, Nucleus, Cytoplasm
SourceKLH conjugated synthetic phosphopeptide derived from human LKB1 around the phosphorylation site of Thr363 [IY(p-T)QD]
Gene ID Number6794
Swiss ProtQ15831
Tested applicationsIF(IHC-P)
Recommended dilutionsIF(IHC-P)(1:50-200)
Crossreactivity Mouse, Rat, Human
Cross-reactive species details not every possible cross-reactivity is known, Due to limited amount of testing and knowledge
Background of the antigen Able to phosphorylate p53/TP53, Acts as a key upstream regulator of AMPK by mediating phosphorylation and activation of AMPK catalytic subunits PRKAA1 and PRKAA2 and thereby regulates processes including: inhibition of signaling pathways that promote cell growth and proliferation when energy levels are low, Acts by phosphorylating the T-loop of AMPK family proteins, Also acts as a mediator of p53/TP53-dependent apoptosis via interaction with p53/TP53: translocates to the mitochondrion during apoptosis and regulates p53/TP53-dependent apoptosis pathways, Also acts as a regulator of cellular polarity by remodeling the actin cytoskeleton, Also phosphorylates non-AMPK family proteins such as STRADA, BRSK1, BRSK2, In vein endothelial cells, Involved in DNA damage response: interacts with p53/TP53 and recruited to the CDKN1A/WAF1 promoter to participate in transcription activation, Isoform 2: Has a role in spermiogenesis, MARK1, MARK2, MARK3, MARK4, NUAK1, NUAK2, PRKAA2, PTEN and possibly p53/TP53, Required for cortical neuron polarization by mediating phosphorylation and activation of BRSK1 and BRSK2, SIK1, SIK2, SIK3 and SNRK but not MELK, activation of autophagy when cells undergo nutrient deprivation, and B-cell differentiation in the germinal center in response to DNA damage, apoptosis and DNA damage response, cell polarity, glucose homeostasis in liver, inhibits PI3K/Akt signaling activity and thus induces apoptosis in response to the oxidant peroxynitrite (in vitro), leading to axon initiation and specification, the relevance of such result in vivo is however unclear and phosphorylation may be indirect and mediated by downstream STK11/LKB1 kinase NUAK1, thereby playing a role in various processes such as cell metabolism, thus promoting their activity: phosphorylates PRKAA1, Tumor suppressor serine/threonine-protein kinase that controls the activity of AMP-activated protein kinase (AMPK) family members
PurificationPurified by Protein A
Storage conditions 50% glycerol and 0, Keep refrigerated at 2 to 8 degrees Celcius for up to one year, 09% sodium azide, Store this antibody in aqueous buffered solution containing 1% BSA
Excitation emission343nm/442nm
Synonyms PJS LKB1
Properties ALEXA FLUOR they should be stored frozen at - 24°, Alexa Fluor 350 conjugates can be used in multi-color flow cytometry with FACS's equipped with a second red laser or red diode, If you buy Antibodies supplied by Bioss Primary Conjugated Antibodies, C, C for long term storage and for short term at + 5°, For facs or microscopy Alexa 1 conjugate
Conjugation ALEXA FLUOR 350, Alexa Fluor
Gene targetLKB1 (Thr363)
Short nameLKB1 (Thr363) Antibody
Technique antibodies against human proteins, antibodies for, Antibody
LabelALEXA FLUOR 350
Alternative name ALEXA FLUOR 350, LKB1 (Thr363) (Antibody to)
Alternative techniqueantibodies
Identity 11389
Gene STK11
Long gene name serine/threonine kinase 11
Synonyms gene name serine/threonine kinase 11 (Peutz-Jeghers syndrome)
Synonyms name polarization-related protein LKB1
Locus 19p13, 3
Discovery year 1998-01-21
GenBank acession U63333
Entrez gene record 6794
Pubmed identfication 9425897
RefSeq identity NM_000455
Havana BLAST/BLAT OTTHUMG00000180118
Locus Specific Databases LRG_319

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