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LRDD Antibody

LRDD Antibody size: 0.1ml 263

Supplier BIOSS PRIMARY UNCONJUGATED ANTIBODIES
Price 263
Size 0.1ml
Contact us Ask Component cell markers and DNA bp. markers are genetic markerser genes or DNA sequenceswith selection audit
Long nameLRDD Primary Polyclonal Antibody
Also known asLRDD PAb
CategoryPrimary Antibodies
ConjugationUnconjugated
Target AntigenLRDD
SpecificityThis is a highly specific antibody against LRDD
Modification(s)None
Modification site(s)Unmodified antibody
ClonalityPolyclonal antibody
Clone numberPolyclonal antibody
Concentration1ug per 1ul
SourceThis antibody was obtained by immunization of the host with KLH conjugated synthetic peptide derived from human LRDD/PIDD
Tested Applications IF(IHC-P), IHC-P, WB
Recommended dilutions IF(IHC-P)(1:50-200), IHC-P(1:100-500), WB(1:100-1000)
Cross reactivity Mouse, Rat, Human
Cross reactive species details not every possible cross-reactivity is known, Due to limited amount of testing and knowledge
Background of the target antigen Increased PIDD expression results in spontaneous activation of caspase-2 and sensitization to apoptosis by genotoxic stimuli, Independently, PIDD also promotes apoptosis downstream of p53 as component of the DNA damage/stress response pathway that connects p53/TP53 to apoptosis, PIDD forms a complex with caspase-2 and the adaptor protein RAIDD, PIDD has also been shown to interact with NEMO/IKBKG and RIP1 and enhance sumoylation and ubiquitination of NEMO/IKBKG, PIDD was also described as a DD-containing protein with unknown function, The N-terminal region of PIDD contains seven leucine-rich repeats (LRRs), a protein interaction motif found in various proteins with diverse functions, an important component for activation of the transcription factor NF-kappa-B, followed by two ZU-5 domains and a C-terminal DD, via interaction with caspase-2 and CRADD/RAIDD, The death domain (DD) containing protein PIDD is a p53 target gene in an erythroleukemia cell line that undergoes G1 phase arrest and subsequent apoptosis after p53 expression
Purification methodThis antibody was purified via Protein A
Storage conditions 50% glycerol and 0, Store at -20°, 09% sodium azide, C for up to 1 year, Keep the antibody in aqueous buffered solution containing 1% BSA
Synonym names DKFZp434D229, Leucine-rich repeats and death domain containing, MGC16925, PIDD, PIDD_HUMAN, p53-induced protein with a death domain, Leucine rich repeats and death domain containing
PropertiesC, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by Bioss Primary Unconjugated Antibodies they should be stored frozen at - 24°
Gene targetLRDD
Short nameLRDD Antibody
Technique antibodies against human proteins, antibodies for, Antibody
Alternative nameLRDD (Antibody to)
Alternative techniqueantibodies
Identity 16491
Gene PIDD1
Long gene name p53-induced death domain protein 1
Synonyms gene LRDD PIDD
Synonyms gene name leucine-rich repeats and death domain containing p53-induced death domain protein
Synonyms MGC16925 DKFZp434D229
Locus 11p15, 5
Discovery year 2001-09-04
GenBank acession AF229178
Entrez gene record 55367
Pubmed identfication 10825539
RefSeq identity NM_145886
Havana BLAST/BLAT OTTHUMG00000133306

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