LRDD Antibody, ALEXA FLUOR 350

LRDD Antibody, ALEXA FLUOR 350 size: 100ul 332

Supplier BIOSS PRIMARY CONJUGATED ANTIBODIES

Price 332

Size 100ul

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Long name	ALEXA FLUOR 350 Conjugated, LRDD Polyclonal Antibody
Also known as	Anti-LRDD PAb ALEXA FLUOR 350
Category	Conjugated Primary Antibodies
Conjugated with	350, ALEXA FLUOR®
Host Organism	Rabbit (Oryctolagus cuniculus)
Target Antigen	LRDD
Specificity	This is a highly specific antibody against LRDD
Modification	Unmodified
Modification Site	None
Clonality	Polyclonal
Clone	Polyclonal antibody
Concentration	1ug per 1ul
Source	This antibody was obtained by immunization of the host with KLH conjugated synthetic peptide derived from human LRDD/PIDD
Tested applications	IF(IHC-P)
Recommended dilutions	IF(IHC-P)(1:50-200)
Crossreactivity	Mouse, Rat, Human
Cross-reactive species details	not every possible cross-reactivity is known, Due to limited amount of testing and knowledge
Background of the antigen	Increased PIDD expression results in spontaneous activation of caspase-2 and sensitization to apoptosis by genotoxic stimuli, Independently, PIDD also promotes apoptosis downstream of p53 as component of the DNA damage/stress response pathway that connects p53/TP53 to apoptosis, PIDD forms a complex with caspase-2 and the adaptor protein RAIDD, PIDD has also been shown to interact with NEMO/IKBKG and RIP1 and enhance sumoylation and ubiquitination of NEMO/IKBKG, PIDD was also described as a DD-containing protein with unknown function, The N-terminal region of PIDD contains seven leucine-rich repeats (LRRs), a protein interaction motif found in various proteins with diverse functions, an important component for activation of the transcription factor NF-kappa-B, followed by two ZU-5 domains and a C-terminal DD, via interaction with caspase-2 and CRADD/RAIDD, The death domain (DD) containing protein PIDD is a p53 target gene in an erythroleukemia cell line that undergoes G1 phase arrest and subsequent apoptosis after p53 expression
Purification	Purified by Protein A
Storage conditions	50% glycerol and 0, Keep refrigerated at 2 to 8 degrees Celcius for up to one year, 09% sodium azide, Store this antibody in aqueous buffered solution containing 1% BSA
Excitation emission	343nm/442nm
Synonyms	MGC16925 DKFZp434D229
Properties	ALEXA FLUOR they should be stored frozen at - 24°, Alexa Fluor 350 conjugates can be used in multi-color flow cytometry with FACS's equipped with a second red laser or red diode, If you buy Antibodies supplied by Bioss Primary Conjugated Antibodies, C, C for long term storage and for short term at + 5°, For facs or microscopy Alexa 1 conjugate
Conjugation	ALEXA FLUOR 350, Alexa Fluor
Gene target	LRDD
Short name	LRDD Antibody
Technique	antibodies against human proteins, antibodies for, Antibody
Label	ALEXA FLUOR 350
Alternative name	ALEXA FLUOR 350, LRDD (Antibody to)
Alternative technique	antibodies
Identity	16491
Gene	PIDD1
Long gene name	p53-induced death domain protein 1
Synonyms gene	LRDD PIDD
Synonyms gene name	leucine-rich repeats and death domain containing p53-induced death domain protein
Locus	11p15, 5
Discovery year	2001-09-04
GenBank acession	AF229178
Entrez gene record	55367
Pubmed identfication	10825539
RefSeq identity	NM_145886
Havana BLAST/BLAT	OTTHUMG00000133306

LRDD Antibody, ALEXA FLUOR 350

LRDD Antibody, ALEXA FLUOR 350 size: 100ul 332

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