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LSD1 Antibody

LSD1 Antibody size: 0.4 ml 406

Supplier NJS POLY
Price 406
Size 0.4 ml
Contact us Ask Component cell markers and DNA bp. markers are genetic markerser genes or DNA sequenceswith selection audit
CategoryAntibody
Concentration pH 7, with 0, 09% sodium azide, 4, In 1X PBS
FormPurified
ConjugationUnconjugated
ClonePolyclonal antibody
Recognised antigenLSD1
Host animalRabbit (Oryctolagus cuniculus)
ClonalityPolyclonal (rabbit origin)
Species reactivity Due to limited knowledge and inability to test the antibody against all known species, Mouse (Mus musculus) , we cannot guarantee that no other cross reactivity can occur, Human (Homo sapiens)
Tested applications ELISA, IF, IHC, WB
Recommended dilutionsIHC (Paraffin): 1:50-1:100, Immunofluorescence: 1:10-1:50, Western blot: 1:1000
NotesTitration of the LSD1 antibody may be required due to differences in protocols and secondary/substrate sensitivity
Intented useThis LSD1 antibodyis to be used only for research purposes and not for diagnostics
Uniprot #O60341
PurityPurified
Description Alone, It acts by oxidizing the substrate by FAD to generate the corresponding imine that is subsequently hydrolyzed, It may also demethylate 'Lys-9' of histone H3, LSD1 contains a SWIRM domain, LSD1 demethylates both mono- and tri-methylted 'Lys-4' of histone H3, This protein is a component of several histone deacetylase complexes, This protein may play a role in the repression of neuronal genes, a FAD-binding motif, a specific tag for epigenetic transcriptional activation, a specific tag for epigenetic transcriptional repression, and an amine oxidase domain, it is unable to demethylate H3 'Lys-4' on nucleosomes and requires the presence of RCOR1/CoREST to achieve such activity, thereby acting as a corepressor, thereby leading to derepression of androgen receptor target genes, though it silences genes by functioning as a histone demethylase, LSD1 is a histone demethylase that specifically demethylates 'Lys-4' of histone H3
ImmunogenA portion of amino acids 108-142 from the human protein was used as the immunogen for this LSD1 antibody
Storage Celcius or lower, Cycles of freezing and thawing can denaturate the peptide chains of the antibodies and reduce their sensitivity and/or change their affinity, Prepare aliqotes in such a manner so that freeze-thaw cycles are minimized, Aliquot the LSD1 antibody and store frozen at -20 deg
PropertiesC, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by NJS poly they should be stored frozen at - 24°
Gene KDM1A
Gene targetLSD1
Short nameLSD1 Antibody
Technique antibodies against human proteins, antibodies for, Antibody
Alternative nameLSD1 (Antibody to)
Alternative techniqueantibodies
Identity 29079
Long gene name lysine demethylase 1A
Synonyms gene AOF2 KDM1
Synonyms gene name amine oxidase (flavin containing) domain 2 lysine (K)-specific demethylase 1
Synonyms KIAA0601 BHC110 LSD1
Locus 1p36, 12
Discovery year 2004-02-26
GenBank acession AL031428
Entrez gene record 23028
Pubmed identfication 9628581 12493763
RefSeq identity NM_015013
Classification Lysine demethylases
Havana BLAST/BLAT OTTHUMG00000003220

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