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MAP3K8 Antibody

MAP3K8 Antibody size: 0.1ml 263

Supplier BIOSS PRIMARY UNCONJUGATED ANTIBODIES
Price 263
Size 0.1ml
Contact us Ask Component cell markers and DNA bp. markers are genetic markerser genes or DNA sequenceswith selection audit
Long nameMAP3K8 Primary Polyclonal Antibody
Also known asMAP3K8 PAb
CategoryPrimary Antibodies
ConjugationUnconjugated
Target AntigenMAP3K8
SpecificityThis is a highly specific antibody against MAP3K8
Modification(s)None
Modification site(s)Unmodified antibody
ClonalityPolyclonal antibody
Clone numberPolyclonal antibody
Concentration1ug per 1ul
Immunogen range140-190/467
Subcellular locationCytoplasm
SourceThis antibody was obtained by immunization of the host with KLH conjugated synthetic peptide derived from human MAP3K8
Gene ID number1326
Swiss ProtP41279
Tested Applications IF(IHC-P), IHC-P, WB
Recommended dilutions IF(IHC-P)(1:50-200), IHC-P(1:100-500), WB(1:100-1000)
Cross reactivity Mouse, Rat, Human
Cross reactive species details not every possible cross-reactivity is known, Due to limited amount of testing and knowledge
Background of the target antigen In adipocytes, In vitro, Involved in mediating host resistance to bacterial infection through negative regulation of type I interferon (IFN) production, Involved in the regulation of T-helper cell differentiation and IFNG expression in T-cells, Isoform 1 shows some transforming activity, May also play a role in the transduction of TNF signals that activate JNK and NF-kappa-B in some cell types, Plays a role in the cell cycle, TLR4-mediated activation of the MAPK/ERK pathway in macrophages, Transduces CD40 and TNFRSF1A signals that activate ERK in B-cells and macrophages, activates MAPK/ERK pathway in an IKBKB-dependent manner in response to IL1B and TNF, activates MAPK/ERK pathway in response to IL1 in an IRAK1-independent manner, although it is much weaker than that of the activated oncogenic variant, and thus may play a role in the regulation of immunoglobulin production, but not insulin, leading to induction of lipolysis, leading to up-regulation of IL8 and CCL4, thus being critical for production of the proinflammatory cytokine TNF-alpha (TNF) during immune responses, Required for lipopolysaccharide (LPS)-induced
Purification methodThis antibody was purified via Protein A
Storage conditions 50% glycerol and 0, Store at -20°, 09% sodium azide, C for up to 1 year, Keep the antibody in aqueous buffered solution containing 1% BSA
Synonym names Cancer Osaka thyroid oncogene, EST, ESTF, MAP3K8, MEKK8, Mitogen-activated protein kinase kinase kinase 8, Proto-oncogene c-Cot, Serine/threonine-protein kinase cot, TPL2, Tpl-2, Tumor progression locus 2, c-COT, COT
PropertiesC, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by Bioss Primary Unconjugated Antibodies they should be stored frozen at - 24°
Gene targetMAP3K8
Short nameMAP3K8 Antibody
Technique antibodies against human proteins, antibodies for, Antibody
Alternative nameMAP3K8 (Antibody to)
Alternative techniqueantibodies
Identity 6860
Gene MAP3K8
Long gene name mitogen-activated protein kinase kinase kinase 8
Synonyms gene COT ESTF
Synonyms Tpl-2 EST c-COT MEKK8
Locus 10p11, 23
Discovery year 1992-09-14
GenBank acession D14497
Entrez gene record 1326
Pubmed identfication 2072910 8479752
RefSeq identity NM_005204
Classification Mitogen-activated protein kinase kinase kinases
Havana BLAST/BLAT OTTHUMG00000017889

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