| Long name | MAPK8IP1 Primary Polyclonal Antibody |
| Also known as | MAPK8IP1 PAb |
| Category | Primary Antibodies |
| Conjugation | Unconjugated |
| Target Antigen | MAPK8IP1 |
| Specificity | This is a highly specific antibody against MAPK8IP1 |
| Modification(s) | None |
| Modification site(s) | Unmodified antibody |
| Clonality | Polyclonal antibody |
| Clone number | Polyclonal antibody |
| Concentration | 1ug per 1ul |
| Immunogen range | 435-485/711 |
| Subcellular location | Cytoplasm |
| Source | This antibody was obtained by immunization of the host with KLH conjugated synthetic peptide derived from human JIP1/MAPK8IP1 |
| Gene ID number | 9479 |
| Swiss Prot | Q9UQF2 |
| Tested Applications | IF(IHC-P), IHC-P, WB |
| Recommended dilutions | IF(IHC-P)(1:50-200), IHC-P(1:100-500), WB(1:100-1000) |
| Cross reactivity | Mouse, Rat, Human |
| Cross reactive species details | not every possible cross-reactivity is known, Due to limited amount of testing and knowledge |
| Background of the target antigen | Appears to have a role in cell signaling in mature and developing nerve terminals, Cytoplasmic MAPK8IP1 causes inhibition of JNK-regulated activity by retaining JNK in the cytoplasm and inhibiting JNK phosphorylation of c-Jun, Directly, Functions as an anti-apoptotic protein and whose level seems to influence the beta-cell death or survival response, May also participate in ApoER2-specific reelin signaling, May function as a regulator of vesicle transport, Required for JNK activation in response to excitotoxic stress, or indirectly, regulates GLUT2 gene expression and beta-cell function, through interactions with the JNK-signaling components and motor proteins (By similarity), The JNK-interacting protein (JIP) group of scaffold proteins selectively mediates JNK signaling by aggregating specific components of the MAPK cascade to form a functional JNK signaling module |
| Purification method | This antibody was purified via Protein A |
| Storage conditions | 50% glycerol and 0, Store at -20°, 09% sodium azide, C for up to 1 year, Keep the antibody in aqueous buffered solution containing 1% BSA |
| Synonym names | C-Jun-amino-terminal kinase-interacting protein 1, IB-1, Islet-brain 1, JIP-1, JIP1, JNK MAP kinase scaffold protein 1, JNK-interacting protein 1, MAPK8IP1, Mitogen-activated protein kinase 8-interacting protein 1, PRKM8IP, IB1 |
| Properties | C, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by Bioss Primary Unconjugated Antibodies they should be stored frozen at - 24° |
| Gene target | MAPK8IP1 |
| Short name | MAPK8IP1 Antibody |
| Technique | antibodies against human proteins, antibodies for, Antibody |
| Alternative name | mitogen-activated protein phosphorylation catalyst 8 interacting protein 1 (Antibody to) |
| Alternative technique | antibodies |
| Alternative to gene target | BT, DNA-templated and biological process this GO :0007165 and signal transduction and biological process this GO :0007258 and JUN phosphorylation and biological process this GO :0008432 and JUN kinase binding and molecular function this GO :0009967 and positive regulation of signal transduction and biological process this GO :0016020 and membrane and cellular component this GO :0016192 and vesicle-mediated transport and biological process this GO :0019894 and kinesin binding and molecular function this GO :0019901 and protein kinase binding and molecular function this GO :0030424 and axon and cellular component this GO :0030425 and dendrite and cellular component this GO :0031434 and mitogen-activated protein kinase kinase binding and molecular function this GO :0031435 and mitogen-activated protein kinase kinase kinase binding and molecular function this GO :0031966 and mitochondrial membrane and cellular component this GO :0042802 and identical protein binding and molecular function this GO :0043005 and neuron projection and cellular component this GO :0043066 and negative regulation of apoptotic process and biological process this GO :0043508 and negative regulation of JUN kinase activity and biological process this GO :0044294 and dendritic growth cone and cellular component this GO :0044295 and axonal growth cone and cellular component this GO :0044297 and cell body and cellular component this GO :0044302 and dentate gyrus mossy fiber and cellular component this GO :0045202 and synapse and cellular component this GO :0046328 and regulation of JNK cascade and biological process this GO :0046329 and negative regulation of JNK cascade and biological process this GO :0048471 and perinuclear region of cytoplasm and cellular component this GO :2001243 and negative regulation of intrinsic apoptotic signaling pathway and biological process, IB1 and JIP-1 and JIP1 and PRKM8IP, MAPK8IP1 and IDBG-41200 and ENSG00000121653 and 9479, Mapk8ip1 and IDBG-192264 and ENSMUSG00000027223 and 19099, identical protein binding, nuclei, this GO :0004860 and protein kinase inhibitor activity and molecular function this GO :0005078 and MAP-kinase scaffold activity and molecular function this GO :0005515 and protein binding and molecular function this GO :0005634 and nucleus and cellular component this GO :0005737 and cytoplasm and cellular component this GO :0005789 and endoplasmic reticulum membrane and cellular component this GO :0005829 and cytosol and cellular component this GO :0006355 and regulation of transcription, this GO :0004860: protein kinase inhibitor activity, this GO :0004860: protein kinase inhibitor activity and also this GO :0005078: MAP-kinase scaffold activity and also this GO :0005515: protein binding and also this GO :0008432: JUN kinase binding and also this GO :0019894: kinesin binding and also this GO :0019901: protein kinase binding and also this GO :0031434: mitogen-activated protein kinase kinase binding and also this GO :0031435: mitogen-activated protein kinase kinase kinase binding and also this GO :0042802: identical protein binding, this GO :0005078: MAP-kinase scaffold activity, this GO :0005515: protein binding, this GO :0008432: JUN kinase binding, this GO :0019894: kinesin binding, this GO :0019901: protein kinase binding, this GO :0031434: mitogen-activated protein kinase kinase binding, this GO :0031435: mitogen-activated protein kinase kinase kinase binding, this GO :0042802: identical protein binding, 105291 and IDBG-637017 and ENSBTAG00000000317 and 524806, mitogen-activated protein kinase 8 interacting protein 1 |
| Identity | 6882 |
| Gene | MAPK8IP1 |
| Long gene name | mitogen-activated protein kinase 8 interacting protein 1 |
| Synonyms gene | PRKM8IP |
| Synonyms | IB1 JIP-1 JIP1 |
| Locus | 11p11, 2 |
| Discovery year | 1999-06-11 |
| Entrez gene record | 9479 |
| Pubmed identfication | 9235893 9442013 |
| RefSeq identity | NM_005456 |
| Havana BLAST/BLAT | OTTHUMG00000134324 |
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