Filters

MAPKAPK2 (Thr222) Antibody, ALEXA FLUOR 350

MAPKAPK2 (Thr222) Antibody, ALEXA FLUOR 350 size: 100ul 350

Supplier BIOSS PRIMARY CONJUGATED ANTIBODIES
Price 350
Size 100ul
Contact us Ask Component cell markers and DNA bp. markers are genetic markerser genes or DNA sequenceswith selection audit
Long name ALEXA FLUOR 350 Conjugated, MAPKAPK2 (Thr222) Polyclonal Antibody
Also known asAnti-MAPKAPK2 Thr222 PAb ALEXA FLUOR 350
CategoryConjugated Primary Antibodies
Conjugated with 350, ALEXA FLUOR®
Host OrganismRabbit (Oryctolagus cuniculus)
Target AntigenMAPKAPK2 Thr222
SpecificityThis is a highly specific antibody against MAPKAPK2 Thr222
ModificationPhosphorylation
Modification SiteThr222
ClonalityPolyclonal
ClonePolyclonal antibody
Concentration1ug per 1ul
Immunogen range192-230/400
Subcellular location Nucleus, Cytoplasm
SourceKLH conjugated synthetic phosphopeptide derived from human MAPKAPK2 around the phosphorylation site of Thr222
Gene ID Number9261
Swiss ProtP49137
Tested applicationsIF(IHC-P)
Recommended dilutionsIF(IHC-P)(1:50-200)
Crossreactivity Bovine, Mouse, Rat, Human
Cross-reactive species details not every possible cross-reactivity is known, Due to limited amount of testing and knowledge
Background of the antigen Also involved in late G2/M checkpoint following DNA damage through a process of post-transcriptional mRNA stabilization: following DNA damage, CDC25B, CDC25C, DNA damage response and transcriptional regulation, ELAVL1, Following stress, HNRNPA, HNRNPA, HSF1, HSP27/HSPB1, Hyd-X-R-X(2)-S, Involved in inflammatory response by regulating tumor necrosis factor (TNF) and IL6 production post-transcriptionally: acts by phosphorylating AU-rich elements (AREs)-binding proteins ELAVL1, Involved in toll-like receptor signaling pathway (TLR) in dendritic cells: required for acute TLR-induced macropinocytosis by phosphorylating and activating RPS6KA3, KRT18, KRT2, LIMK1, LSP1, Mediates phosphorylation of HSP27/HSPB1 in response to stress, PABPC1, PABPC1 and TTP/ZFP36, PARN, PDE4A, Phosphorylates ALOX5, Phosphorylates serine in the peptide sequence, Phosphorylation of TTP/ZFP36, RCSD1, RPS6KA3, TAB3 and TTP/ZFP36, a major post-transcriptional regulator of TNF, cell cycle control, cell migration, chromatin remodeling, endocytosis, it is phosphorylated and activated by MAP kinase p38-alpha/MAPK14, leading to dissociate HSP27/HSPB1 from large small heat-shock protein (sHsps) oligomers and impair their chaperone activities and ability to protect against oxidative stress effectively, leading to phosphorylation of substrates, leading to regulate the stability and translation of TNF and IL6 mRNAs, leading to stabilize GADD45A mRNA, promotes its binding to 14-3-3 proteins and reduces its ARE mRNA affinity leading to inhibition of dependent degradation of ARE-containing transcript, relocalizes from nucleus to cytoplasm and phosphorylates HNRNPA and PARN, reorganization of the cytoskeleton, where Hyd is a large hydrophobic residue, Stress-activated serine/threonine-protein kinase involved in cytokines production
PurificationPurified by Protein A
Storage conditions 50% glycerol and 0, Keep refrigerated at 2 to 8 degrees Celcius for up to one year, 09% sodium azide, Store this antibody in aqueous buffered solution containing 1% BSA
Excitation emission343nm/442nm
Properties ALEXA FLUOR they should be stored frozen at - 24°, Alexa Fluor 350 conjugates can be used in multi-color flow cytometry with FACS's equipped with a second red laser or red diode, If you buy Antibodies supplied by Bioss Primary Conjugated Antibodies, C, C for long term storage and for short term at + 5°, For facs or microscopy Alexa 1 conjugate
Conjugation ALEXA FLUOR 350, Alexa Fluor
Gene targetMAPKAPK2 (Thr222)
Short nameMAPKAPK2 (Thr222) Antibody
Technique antibodies against human proteins, antibodies for, Antibody
LabelALEXA FLUOR 350
Alternative name ALEXA FLUOR 350, MAPKAPK2 (Thr222) (Antibody to)
Alternative techniqueantibodies
Identity 6887
Gene MAPKAPK2
Long gene name mitogen-activated protein kinase-activated protein kinase 2
Locus 1q32, 1
Discovery year 1999-03-26
GenBank acession U12779
Entrez gene record 9261
Pubmed identfication 8179591 8280084
RefSeq identity NM_004759
Classification Mitogen-activated protein kinase-activated protein kinases
Havana BLAST/BLAT OTTHUMG00000036342

Similar products

Subscribe to our Newsletter