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MAPKAPK5 Antibody

MAPKAPK5 Antibody size: 0.1ml 263

Supplier BIOSS PRIMARY UNCONJUGATED ANTIBODIES
Price 263
Size 0.1ml
Contact us Ask Component cell markers and DNA bp. markers are genetic markerser genes or DNA sequenceswith selection audit
Long nameMAPKAPK5 Primary Polyclonal Antibody
Also known asMAPKAPK5 PAb
CategoryPrimary Antibodies
ConjugationUnconjugated
Target AntigenMAPKAPK5
SpecificityThis is a highly specific antibody against MAPKAPK5
Modification(s)None
Modification site(s)Unmodified antibody
ClonalityPolyclonal antibody
Clone numberPolyclonal antibody
Concentration1ug per 1ul
Immunogen range100-150/473
Subcellular location Nucleus, Cytoplasm
SourceThis antibody was obtained by immunization of the host with KLH conjugated synthetic peptide derived from human MAPKAPK5
Gene ID number8550
Swiss ProtQ8IW41
Tested Applications IF(IHC-P), IHC-P, WB
Recommended dilutions IF(IHC-P)(1:50-200), IHC-P(1:100-500), WB(1:100-1000)
Cross reactivity Mouse, Rat, Human
Cross reactive species details not every possible cross-reactivity is known, Due to limited amount of testing and knowledge
Background of the target antigen 2 post-transcriptional regulators of MYC that bind to the 3'UTR of MYC transcript and prevent MYC translation, Acts as a negative regulator of mTORC1 signaling by mediating phosphorylation and inhibition of RHEB, Acts as a tumor suppressor by mediating Ras-induced senescence and phosphorylating p53/TP53, ERK3/MAPK6, ERK3/MAPK6 (or ERK4/MAPK4) is phosphorylated and then mediates phosphorylation and activation of MAPKAPK5, ERK4/MAPK4, HSP27/HSPB1, Involved in post-transcriptional regulation of MYC by mediating phosphorylation of FOXO3: phosphorylation of FOXO3 leads to promote nuclear localization of FOXO3, Mediates phosphorylation of HSP27/HSPB1 in response to PKA/PRKACA stimulation, Part of the atypical MAPK signaling via its interaction with ERK3/MAPK6 or ERK4/MAPK4: the precise role of the complex formed with ERK3/MAPK6 or ERK4/MAPK4 is still unclear, Phosphorylates FOXO3, but the complex follows a complex set of phosphorylation events: upon interaction with atypical MAPK (ERK3/MAPK6 or ERK4/MAPK4), enabling expression of miR-34b and miR-34c, inducing F-actin rearrangement, p53/TP53 and RHEB, which in turn phosphorylates ERK3/MAPK6 (or ERK4/MAPK4), Tumor suppressor serine/threonine-protein kinase involved in mTORC1 signaling and post-transcriptional regulation
Purification methodThis antibody was purified via Protein A
Storage conditions 50% glycerol and 0, Store at -20°, 09% sodium azide, C for up to 1 year, Keep the antibody in aqueous buffered solution containing 1% BSA
Synonym names MAP kinase-activated protein kinase 5, MAPK-activated protein kinase 5, MAPKAP kinase 5, MAPKAP-K5, MAPKAPK-5, MAPKAPK5, MK-5, PRAK, p38-regulated/activated protein kinase, MK5
PropertiesC, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by Bioss Primary Unconjugated Antibodies they should be stored frozen at - 24°
Gene targetMAPKAPK5
Short nameMAPKAPK5 Antibody
Technique antibodies against human proteins, antibodies for, Antibody
Alternative nameMAPKAPK5 (Antibody to)
Alternative techniqueantibodies
Identity 6889
Gene MAPKAPK5
Long gene name mitogen-activated protein kinase-activated protein kinase 5
Synonyms PRAK
Locus 12q24, 12-q24, 13
Discovery year 1999-03-26
GenBank acession AF032437
Entrez gene record 8550
Pubmed identfication 9628874
RefSeq identity NM_139078
Classification Mitogen-activated protein kinase-activated protein kinases
Havana BLAST/BLAT OTTHUMG00000169605

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