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MBD1 Antibody, ALEXA FLUOR 488

MBD1 Antibody, ALEXA FLUOR 488 size: 100ul 332

Supplier BIOSS PRIMARY CONJUGATED ANTIBODIES
Price 332
Size 100ul
Contact us Ask Component cell markers and DNA bp. markers are genetic markerser genes or DNA sequenceswith selection audit
Long name ALEXA FLUOR 488 Conjugated, MBD1 Polyclonal Antibody
Also known asAnti-MBD1 PAb ALEXA FLUOR 488
CategoryConjugated Primary Antibodies
Conjugated with 488, ALEXA FLUOR®
Host OrganismRabbit (Oryctolagus cuniculus)
Target AntigenMBD1
SpecificityThis is a highly specific antibody against MBD1
ModificationUnmodified
Modification SiteNone
ClonalityPolyclonal
ClonePolyclonal antibody
Concentration1ug per 1ul
SourceThis antibody was obtained by immunization of the host with KLH conjugated synthetic peptide derived from human MBD1
Gene ID Number4152
Tested applicationsIF(IHC-P)
Recommended dilutionsIF(IHC-P)(1:50-200)
Crossreactivity Mouse, Rat, Human
Cross-reactive species details not every possible cross-reactivity is known, Due to limited amount of testing and knowledge
Background of the antigen In some microsatellite unstable tumors MBD4 is mutated at an exonic polynucleotide tract, MBD1, MBD2, MBD2 and MBD4 (also known as MED1) were later found to colocalize with foci of heavily methylated satellite DNA and believed to mediate the biological functions of the methylation signal, MBD3, MBD3 does not bind methylated DNA both in vivo and in vitro, MBD4 have homology to bacterial base excision repair DNA N-glycosylases/lyases, MeCP2 and MBD1 (PCM1) are first found to repress transcription by binding specifically to methylated DNA, Surprisingly, The demethylation enzyme was recently found to be a mammalian protein, The enzyme is able to revert methylated cytosine bases to cytosines within the particular dinucleotide sequence mdCpdG by catalyzing the cleaving of the methyl group as methanol, The methylation pattern involves the enzymatic processes of methylation and demethylation, and MBD4 are found to be expressed in somatic tissues, but the expression of MBD1 and MBD2 is reduced or absent in embryonic stem cells, is imperative to proper development and regulates gene expression, or the addition of methyl groups to cytosine bases in the dinucleotide CpG, which are known to be deficient in MeCP1 activity, which exhibits demethylase activity associated to a methyl-CpG-binding domain (MBD), DNA methylation
PurificationPurified by Protein A
Storage conditions 50% glycerol and 0, Keep refrigerated at 2 to 8 degrees Celcius for up to one year, 09% sodium azide, Store this antibody in aqueous buffered solution containing 1% BSA
Excitation emission499nm/519nm
Synonyms PCM1 CXXC3
Properties ALEXA FLUOR they should be stored frozen at - 24°, Alexa Fluor 488 has the same range to that of fluorescein isothiocyanate (FITC), Also Alexa Fluor 488 is pH stable, As a result of this photo stability, If you buy Antibodies supplied by Bioss Primary Conjugated Antibodies, It is distinguished in the FL1 of a FACS-Calibur or FACScan, has a very high photo stability, it has turned into an antibody for fluorescent microscopy and FACS FLOW cytometry, yet the MBD1 Antibody, C, C for long term storage and for short term at + 5°, For facs or microscopy Alexa 1 conjugate
ConjugationAlexa Fluor
Gene targetMBD1
Short nameMBD1 Antibody
Technique antibodies against human proteins, antibodies for, Antibody
LabelALEXA FLUOR 488
Alternative name ALEXA FLUOR 488, MBD1 (Antibody to)
Alternative techniqueantibodies
Identity 6916
Gene MBD1
Long gene name methyl-CpG binding domain protein 1
Locus 18q21, 1
Discovery year 1997-10-29
GenBank acession Y10746
Entrez gene record 4152
Pubmed identfication 9207790 10441743
RefSeq identity NM_015846
Classification Methyl-CpG binding domain containing Zinc fingers CXXC-type
Havana BLAST/BLAT OTTHUMG00000132669

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