Filters

MBD1 Antibody, Cy5.5 Conjugated

MBD1 Antibody, Cy5.5 Conjugated size: 0.1ml 350

Supplier BIOSS PRIMARY CONJUGATED ANTIBODIES 1
Price 350
Size 0.1ml
Contact us Ask Component cell markers and DNA bp. markers are genetic markerser genes or DNA sequenceswith selection audit
Long name Cy5, 5 Conjugated, MBD1 Polyclonal Antibody
CategoryConjugated Primary Antibodies
Conjugation Cy5, 5, 5, Cy5
Host OrganismRabbit (Oryctolagus cuniculus)
Target AntigenMBD1
SpecificityThis is a highly specific antibody against MBD1
ModificationUnmodified
Modification siteNone
ClonalityPolyclonal
ClonePolyclonal antibody
Concentration1ug per 1ul
SourceKLH conjugated synthetic peptide derived from human MBD1
Gene ID number4152
Tested applicationsIF(IHC-P)
Recommended dilutionsIF(IHC-P)(1:50-200)
Crossreactivity Mouse, Rat, Human
Crossreactive species details not every possible cross-reactivity is known, Due to limited amount of testing and knowledge
Antigen background In some microsatellite unstable tumors MBD4 is mutated at an exonic polynucleotide tract, MBD1, MBD2, MBD2 and MBD4 (also known as MED1) were later found to colocalize with foci of heavily methylated satellite DNA and believed to mediate the biological functions of the methylation signal, MBD3, MBD3 does not bind methylated DNA both in vivo and in vitro, MBD4 have homology to bacterial base excision repair DNA N-glycosylases/lyases, MeCP2 and MBD1 (PCM1) are first found to repress transcription by binding specifically to methylated DNA, Surprisingly, The demethylation enzyme was recently found to be a mammalian protein, The enzyme is able to revert methylated cytosine bases to cytosines within the particular dinucleotide sequence mdCpdG by catalyzing the cleaving of the methyl group as methanol, The methylation pattern involves the enzymatic processes of methylation and demethylation, and MBD4 are found to be expressed in somatic tissues, but the expression of MBD1 and MBD2 is reduced or absent in embryonic stem cells, is imperative to proper development and regulates gene expression, or the addition of methyl groups to cytosine bases in the dinucleotide CpG, which are known to be deficient in MeCP1 activity, which exhibits demethylase activity associated to a methyl-CpG-binding domain (MBD), DNA methylation
Purification methodThis antibody was purified via Protein A
Storage conditions 50% glycerol and 0, Store refrigerated at 2 to 8 degrees Celcius for up to 1 year, 09% sodium azide, Keep the antibody in an aqueous buffered solution containing 1% BSA
Excitation Emission675nm/694nm
Synonyms PCM1 CXXC3
Properties Cy5 antibodies are excited by the 650-nanometer wave of an argon laser and detected at a 670-nanometer captor, C, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by Bioss Primary Conjugated Antibodies they should be stored frozen at - 24°
ConjugatedThese antibodies are excite for emission at 678nm and detected at a 694 , nm wavelengths
Gene targetMBD1 Conjugated
Short name Conjugated, MBD1 Antibody
Technique antibodies against human proteins, antibodies for, antibody Conjugates, Antibody
Label5, Cy5
Alternative name cyanine 5, 5 coupled, MBD1 (Antibody to)
Alternative techniqueantibodies
Identity 6916
Gene MBD1
Long gene name methyl-CpG binding domain protein 1
Locus 18q21, 1
Discovery year 1997-10-29
GenBank acession Y10746
Entrez gene record 4152
Pubmed identfication 9207790 10441743
RefSeq identity NM_015846
Classification Methyl-CpG binding domain containing Zinc fingers CXXC-type
Havana BLAST/BLAT OTTHUMG00000132669

Similar products

Subscribe to our Newsletter