| Long name | MCL1 Primary Polyclonal Antibody |
| Also known as | MCL1 PAb |
| Category | Primary Antibodies |
| Conjugation | Unconjugated |
| Target Antigen | MCL1 |
| Specificity | This is a highly specific antibody against MCL1 |
| Modification(s) | None |
| Modification site(s) | Unmodified antibody |
| Clonality | Polyclonal antibody |
| Clone number | Polyclonal antibody |
| Concentration | 1ug per 1ul |
| Immunogen range | 210-248/350 |
| Subcellular location | Helical |
| Source | This antibody was obtained by immunization of the host with KLH conjugated synthetic peptide derived from human MCL1 |
| Gene ID number | 4170 |
| Swiss Prot | Q07820 |
| Tested Applications | IF(IHC-P), IHC-P, WB |
| Recommended dilutions | IF(IHC-P)(1:50-200), IHC-P(1:100-500), WB(1:100-1000) |
| Cross reactivity | Mouse, Rat, Human |
| Cross reactive species details | not every possible cross-reactivity is known, Due to limited amount of testing and knowledge |
| Background of the target antigen | Isoform 1 inhibits apoptosis, Isoform 2 promotes apoptosis, Mediates its effects by interactions with a number of other regulators of apoptosis, and in the maintenance of viability but not of proliferation, Involved in the regulation of apoptosis versus cell survival |
| Purification method | This antibody was purified via Protein A |
| Storage conditions | 50% glycerol and 0, Store at -20°, 09% sodium azide, C for up to 1 year, Keep the antibody in aqueous buffered solution containing 1% BSA |
| Synonym names | BCL2L3, Bcl-2-like protein 3, Bcl-2-related protein EAT/mcl1, EAT, Induced myeloid leukemia cell differentiation protein Mcl-1, MCL1, MCL1-ES, MCL1L, MCL1S, Mcl-1, bcl2-L-3, mcl1/EAT, TM |
| Properties | C, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by Bioss Primary Unconjugated Antibodies they should be stored frozen at - 24° |
| Gene target | MCL1 |
| Short name | MCL1 Antibody |
| Technique | antibodies against human proteins, antibodies for, Antibody |
| Alternative name | myeloid cell leukemia sequence 1 (BCL2-related) (Antibody to) |
| Alternative technique | antibodies |
| Alternative to gene target | BH3 domain binding, MCL1 and IDBG-102145 and ENSG00000143384 and 4170, Mcl1 and IDBG-173221 and ENSMUSG00000038612 and 17210, bcl2-L-3 and BCL2L3 and EAT and Mcl-1 and MCL1-ES and mcl1/EAT and MCL1L and MCL1S and TM, nuclei, this GO :0001709 and cell fate determination and biological process this GO :0005515 and protein binding and molecular function this GO :0005634 and nucleus and cellular component this GO :0005654 and nucleoplasm and cellular component this GO :0005737 and cytoplasm and cellular component this GO :0005739 and mitochondrion and cellular component this GO :0005741 and mitochondrial outer membrane and cellular component this GO :0005759 and mitochondrial matrix and cellular component this GO :0005829 and cytosol and cellular component this GO :0007275 and multicellular organismal development and biological process this GO :0008630 and intrinsic apoptotic signaling pathway in response to DNA damage and biological process this GO :0008637 and apoptotic mitochondrial changes and biological process this GO :0015266 and protein channel activity and molecular function this GO :0016020 and membrane and cellular component this GO :0016021 and integral component of membrane and cellular component this GO :0019725 and cellular homeostasis and biological process this GO :0034097 and response to cytokine and biological process this GO :0042803 and protein homodimerization activity and molecular function this GO :0042981 and regulation of apoptotic process and biological process this GO :0043066 and negative regulation of apoptotic process and biological process this GO :0046982 and protein heterodimerization activity and molecular function this GO :0051434 and BH3 domain binding and molecular function this GO :0071806 and protein transmembrane transport and biological process this GO :0097136 and Bcl-2 family protein complex and cellular component this GO :0097192 and extrinsic apoptotic signaling pathway in absence of ligand and biological process this GO :0097194 and execution phase of apoptosis and biological process this GO :1900118 and negative regulation of execution phase of apoptosis and biological process this GO :2000811 and negative regulation of anoikis and biological process this GO :2001020 and regulation of response to DNA damage stimulus and biological process this GO :2001240 and negative regulation of extrinsic apoptotic signaling pathway in absence of ligand and biological process this GO :2001243 and negative regulation of intrinsic apoptotic signaling pathway and biological process, this GO :0005515: protein binding, this GO :0005515: protein binding and also this GO :0015266: protein channel activity and also this GO :0042803: protein homodimerization activity and also this GO :0046982: protein heterodimerization activity and also this GO :0051434: BH3 domain binding, this GO :0015266: protein channel activity, this GO :0042803: protein homodimerization activity, this GO :0046982: protein heterodimerization activity, this GO :0051434: BH3 domain binding, myeloid cell leukemia sequence 1 (BCL2-related) |
| Identity | 6943 |
| Gene | MCL1 |
| Long gene name | BCL2 family apoptosis regulator |
| Synonyms gene name | myeloid cell leukemia sequence 1 (BCL2-related) myeloid cell leukemia 1 |
| Synonyms | BCL2L3 Mcl-1 |
| Locus | 1q21, 2 |
| Discovery year | 1993-11-09 |
| GenBank acession | BC017197 |
| Entrez gene record | 4170 |
| Pubmed identfication | 7682708 7835896 |
| RefSeq identity | NM_021960 |
| Classification | BCL2 family |
| Havana BLAST/BLAT | OTTHUMG00000034867 |
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