| Long name | MDM2 Primary Polyclonal Antibody |
| Also known as | MDM2 PAb |
| Category | Primary Antibodies |
| Conjugation | Unconjugated |
| Target Antigen | MDM2 |
| Specificity | This is a highly specific antibody against MDM2 |
| Modification(s) | None |
| Modification site(s) | Unmodified antibody |
| Clonality | Polyclonal antibody |
| Clone number | Polyclonal antibody |
| Concentration | 1ug per 1ul |
| Immunogen range | 440-491/491 |
| Subcellular location | Nucleus, Cytoplasm |
| Source | This antibody was obtained by immunization of the host with KLH conjugated synthetic peptide derived from human MDM2 |
| Gene ID number | 4193 |
| Swiss Prot | Q00987 |
| Tested Applications | IF(IHC-P), IHC-P, WB |
| Recommended dilutions | IF(IHC-P)(1:50-200), IHC-P(1:100-500), WB(1:100-1000) |
| Cross reactivity | Mouse, Rat, Human |
| Cross reactive species details | not every possible cross-reactivity is known, Due to limited amount of testing and knowledge |
| Background of the target antigen | Also acts as a ubiquitin ligase E3 toward itself and ARRB1, Also component of the TRIM28/KAP1-ERBB4-MDM2 complex which links growth factor and DNA damage response pathways, Component of the TRIM28/KAP1-MDM2-p53/TP53 complex involved in stabilizing p53/TP53, Inhibits DAXX-mediated apoptosis by inducing its ubiquitination and degradation, Inhibits p53/TP53- and p73/TP73-mediated cell cycle arrest and apoptosis by binding its transcriptional activation domain, Mediates ubiquitination and subsequent proteasome degradation of DYRK2 in nucleus, Permits the nuclear export of p53/TP53, Promotes proteasome-dependent ubiquitin-independent degradation of retinoblastoma RB1 protein, Ubiquitinates IGF1R and SNAI1 and promotes them to proteasomal degradation, leading to its degradation by the proteasome, E3 ubiquitin-protein ligase that mediates ubiquitination of p53/TP53 |
| Purification method | This antibody was purified via Protein A |
| Storage conditions | 50% glycerol and 0, Store at -20°, 09% sodium azide, C for up to 1 year, Keep the antibody in aqueous buffered solution containing 1% BSA |
| Synonym names | ACTFS, Double minute 2 protein, E3 ubiquitin-protein ligase Mdm2, MDM2, Oncoprotein Mdm2, hdm2, p53-binding protein Mdm2, HDMX |
| Properties | C, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by Bioss Primary Unconjugated Antibodies they should be stored frozen at - 24° |
| Gene target | MDM2 |
| Short name | MDM2 Antibody |
| Technique | antibodies against human proteins, antibodies for, Antibody |
| Alternative name | MDM2 (Antibody to) |
| Alternative technique | antibodies |
| Identity | 6973 |
| Gene | MDM2 |
| Long gene name | MDM2 proto-oncogene |
| Synonyms gene name | E3 ubiquitin protein ligase , human homolog of, mouse double minute 2, p53 binding protein (mouse) Mdm2 p53 binding protein homolog (mouse) MDM2 proto-oncogene, p53-binding protein Mdm2, transformed 3T3 cell double minute 2 |
| Synonyms | HDM2 MGC5370 |
| Locus | 12q15 |
| Discovery year | 1993-12-10 |
| Entrez gene record | 4193 |
| Pubmed identfication | 1614537 16905769 |
| RefSeq identity | NM_006880 |
| Classification | Zinc fingers RANBP2-type |
| Havana BLAST/BLAT | OTTHUMG00000142827 |
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